C0MEX3 (KHSE_STRS7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	SZO_09000

Organism

Streptococcus equi subsp. zooepidemicus (strain H70) [Complete proteome] [HAMAP]

Taxonomic identifier

553483 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Homoserine kinase HAMAP MF_00384		PRO_1000205740
Regions
	Nucleotide binding	78 – 88	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	C0MEX3 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 085579FA62F62B21	FASTA	286	30,928
	10 20 30 40 50 60 MKIRVPATSA NLGPGFDSMG IAVSKYLEVD ILEESEQWFI EHDLGDIPND DSNLLIQTAL 70 80 90 100 110 120 RLAPNIPAHR LKMTSDIPLA RGLGSSSSVI VAGIELANQL GHLNLTADRK LAIATRIEGH 130 140 150 160 170 180 PDNVAPAIFG QLVIASQIGK DVDYIIAPFP DLSLVCFIPD YELKTSDSRD VLPKQLSYKQ 190 200 210 220 230 240 AVAASSVANL AIAALLTGNL KKAGRAIEND QFHEIYRQRL VREFQPIKRA AAANGAYATY 250 260 270 280 LSGAGPAIMV MCPNEKKMAI YEAIEQLGLI GQLVSLELDR QGLCLV

References

[1]

"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens." Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A. , Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J., Waller A.S. PLoS Pathog. 5:E1000346-E1000346(2009) [PubMed: 19325880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: H70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM204884 Genomic DNA. Translation: CAW99136.1.
RefSeq	YP_002744427.1. NC_012470.1.
3D structure databases
ProteinModelPortal	C0MEX3.
ModBase	Search...
Protein-protein interaction databases
STRING	C0MEX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000065319; EBSTRP00000061925; EBSTRG00000064526.
GeneID	7695235.
GenomeReviews	Gene locus SZO_09000 in contig FM204884_GR.
KEGG	seq:SZO_09000.
PATRIC	19651520. VBIStrEqu35012_0957.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027810.
OMA	NNALMST.
ProtClustDB	CLSK2480246.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_STRS7

Accession

Primary (citable) accession number: C0MEX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program