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Protein

Acetate kinase

Gene

ackA

Organism
Streptococcus equi subsp. zooepidemicus (strain H70)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi383MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi283 – 285ATPUniRule annotation3
Nucleotide bindingi331 – 335ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:SZO_01070
OrganismiStreptococcus equi subsp. zooepidemicus (strain H70)
Taxonomic identifieri553483 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001368 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002019091 – 399Acetate kinaseAdd BLAST399

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi40041.SZO_01070.

Structurei

3D structure databases

ProteinModelPortaliC0MEF7.
SMRiC0MEF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C0MEF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTIAINAG SSSLKWQLYQ MPEEKVLAQG IIERIGLTDS ISTVKYDGKK
60 70 80 90 100
EEHILDIPDH TEAVKRLLND LIHFGIIGTY DEITGVGHRI VAGGEYFKES
110 120 130 140 150
VVVDDKVVEQ VEELAALAPL HNPGAAAGIR AFRKILPDIT SVCVFDTSFH
160 170 180 190 200
TTMQKHTYLY PIPQKYYTDY KVRKYGAHGT SHKYVAEEAA KMLGRPLDEL
210 220 230 240 250
KLITAHVGNG VSITANYHGQ SVDTSMGFTP LAGPMMGTRS GDIDPAIIPY
260 270 280 290 300
LIAQDPELKD AADVVNMLNK QSGLGGVSGI SSDMRDIEAG LQANNPDAVL
310 320 330 340 350
AYNIFIDRIK KFIGQYFAVL NGADALVFTA GMGENAPLMR QDVVNGLSWF
360 370 380 390
GMEIDPEKNV FGYRGDISTA ASKVKVLVVS TDEELCIARD VERLKQTIS
Length:399
Mass (Da):43,583
Last modified:May 5, 2009 - v1
Checksum:i3B381D6807B02126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204884 Genomic DNA. Translation: CAW97747.1.

Genome annotation databases

EnsemblBacteriaiCAW97747; CAW97747; SZO_01070.
KEGGiseq:SZO_01070.

Similar proteinsi

Entry informationi

Entry nameiACKA_STRS7
AccessioniPrimary (citable) accession number: C0MEF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families