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C0MDS5 (LACG_STRS7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phospho-beta-galactosidase
EC=3.2.1.85
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name=PGALase
P-beta-Gal
Short name=PBG
Gene names
Name:lacG
Ordered Locus Names:SZO_15220
OrganismStreptococcus equi subsp. zooepidemicus (strain H70) [Complete proteome] [HAMAP]
Taxonomic identifier553483 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP MF_01574

Pathway

Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP MF_01574

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4694696-phospho-beta-galactosidase HAMAP MF_01574
PRO_1000215584

Sites

Active site1601Proton donor By similarity
Active site3751Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
C0MDS5 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 849F2FFA4A9F4813

FASTA46953,509
        10         20         30         40         50         60 
MIKRLPDDFI FGGATAAYQA EGATTIDGKG AVAWDRYLKD NYWYTAEPAS DFYHQYPVDL 

        70         80         90        100        110        120 
ALAEQFGING IRISIAWSRI FPEGFGEVNA KGVAFYHSLF AECHKHHVEP FVTLHHFDTP 

       130        140        150        160        170        180 
EALHSRGDFL NRENIDHFVA YAAYCFKEFP EVTYWTTFNE IGPIGDGQYL VGKFPPGISY 

       190        200        210        220        230        240 
DLAKVFQSHH NMMLAHARAL VHYKEQAYPG EIGIVHALPT KYPLDPKKPG DVLAAELDDI 

       250        260        270        280        290        300 
IHNKFILDAT YLGQYSEKTM AGVKHILAEN GGSLDLRPED FELLQAAKDL NDFLGINYYM 

       310        320        330        340        350        360 
SDWLRAFDGE TEIIHNGKGE KGGSKYQIKG VGQRVFDVDV PRTDWDWMIY PQGLYDQIMR 

       370        380        390        400        410        420 
IKADYPGYKK IYITENGLGY KDTCIDGRID DDARIDYIKQ HLAVIADAIS TGANVKGYFI 

       430        440        450        460 
WSLMDVFSWS NGYDKRYGLF YVDFETQKRY PKKSAYWYQQ LAATKTISM

« Hide

References

[1]"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens."
Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A. expand/collapse author list , Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J., Waller A.S.
PLoS Pathog. 5:E1000346-E1000346(2009) [PubMed: 19325880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM204884 Genomic DNA. Translation: CAX00199.1.
RefSeqYP_002745039.1. NC_012470.1.

3D structure databases

ProteinModelPortalC0MDS5.
ModBaseSearch...

Protein-protein interaction databases

STRINGC0MDS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000065710; EBSTRP00000061258; EBSTRG00000064700.
GeneID7694666.
GenomeReviewsGene locus SZO_15220 in contig FM204884_GR.
KEGGseq:SZO_15220.
PATRIC19652873. VBIStrEqu35012_1632.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027409.
OMAPTGYGEV.
ProtClustDBPRK13511.

Family and domain databases

HAMAPMF_01574. LacG.
[Tree]
InterProIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KOK01220.
PANTHERPTHR10353. Glyco_hydro_1. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMsTIGR01233. LacG. 1 hit.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLACG_STRS7
AccessionPrimary (citable) accession number: C0MDS5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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