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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Streptococcus equi subsp. zooepidemicus (strain H70)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi288Magnesium or manganese 1UniRule annotation1
Metal bindingi301Magnesium or manganese 1UniRule annotation1
Metal bindingi301Magnesium or manganese 2UniRule annotation1
Metal bindingi303Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 217ATPUniRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:SZO_13560
OrganismiStreptococcus equi subsp. zooepidemicus (strain H70)
Taxonomic identifieri553483 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001368 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002022061 – 348D-alanine--D-alanine ligaseAdd BLAST348

Interactioni

Protein-protein interaction databases

STRINGi40041.SZO_13560.

Structurei

3D structure databases

ProteinModelPortaliC0MCV8.
SMRiC0MCV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 334ATP-graspUniRule annotationAdd BLAST203

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000011593.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom_sf.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C0MCV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQTLILLY GGRSAEREVS VLSAESVMRA VDYTKFFVKT YFISQTGQFI
60 70 80 90 100
KTQEFSSRPT LTERLMTNDT IRLEQQIRPS DIYEEGAVVF PVLHGPMGED
110 120 130 140 150
GSIQGFLEVL RMPYVGTNIL SSSVAMDKIT TKRVLESAGI PQVAYTVYIE
160 170 180 190 200
GQDLDRCLAE TEAALSYPVF VKPANMGSSV GISKAESEEE LRAAILLALT
210 220 230 240 250
YDSRILIEQG VLAREIEVGL LGNTDVKSTL PGEVVKNVDF YDYQAKYIDN
260 270 280 290 300
EITMAIPATI DESAMTSMRI YAETAFKAIG ACGLSRCDFF LGQDGQIYLN
310 320 330 340
ELNTMPGFTQ WSMYPLLWEH MGLNYAELIE ELVRLAQEMF EKREGHLI
Length:348
Mass (Da):38,931
Last modified:May 5, 2009 - v1
Checksum:i46FFE280C461ABA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204884 Genomic DNA. Translation: CAW99921.1.

Genome annotation databases

EnsemblBacteriaiCAW99921; CAW99921; SZO_13560.
KEGGiseq:SZO_13560.

Similar proteinsi

Entry informationi

Entry nameiDDL_STRS7
AccessioniPrimary (citable) accession number: C0MCV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families