ID   C0MCG2_STRS7            Unreviewed;      1546 AA.
AC   C0MCG2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=SZO_05310 {ECO:0000313|EMBL:CAW98510.1};
OS   Streptococcus equi subsp. zooepidemicus (strain H70).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553483 {ECO:0000313|Proteomes:UP000001368};
RN   [1] {ECO:0000313|EMBL:CAW98510.1, ECO:0000313|Proteomes:UP000001368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H70 {ECO:0000313|EMBL:CAW98510.1,
RC   ECO:0000313|Proteomes:UP000001368};
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F.,
RA   Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M.,
RA   Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A.,
RA   Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C.,
RA   Maskell D.J., Parkhill J., Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FM204884; CAW98510.1; -; Genomic_DNA.
DR   KEGG; seq:SZO_05310; -.
DR   PATRIC; fig|40041.11.peg.562; -.
DR   eggNOG; COG2273; Bacteria.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_246588_0_0_9; -.
DR   Proteomes; UP000001368; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd08023; GH16_laminarinase_like; 1.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 2.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000757; GH16.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   NCBIfam; TIGR01168; YSIRK_signal; 1.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF00722; Glyco_hydro_16; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS51762; GH16_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:CAW98510.1};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          260..550
FT                   /note="GH16"
FT                   /evidence="ECO:0000259|PROSITE:PS51762"
FT   REGION          1242..1270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1546 AA;  169787 MW;  EC1A64DB75AB7E72 CRC64;
     MLFNPIGKEQ IRKYAIKKLS VGVASVCVGI GLAAGLPVVV YADDVSEVSL QQPTKAAVTE
     ISHEQEPQAT DTDSEALVVS EETTVDEAVV ANAVTSNAAD QTADEEKSNA PVELNKVANG
     GFDNDYVSNK NQWQYREGGH SVLTTENNNS YAEVTSGTLD EHILQKVSTT VGKTYTLEAD
     VKVEADTPHN GLYLTAKESN HNLQGPVIKE VSLTDTDGTW SHIKLSFTAT TSETFVGLVK
     RLEASSPETL AASASIDNVS VVEENDYELI WQDEFSGDQL NQENWGYELG SIRGNEQQHY
     TDSTENIYLE NGNLVLNVTE RKGEDRYANP RGGTSARQVI YDSGSVRTVG KQEFLYGRIE
     ARAKLPKGKG AFPAFWTLGA DFTLDGDIAS TQGYGWPSTG ELDIMELIGA PNGEHEGELA
     EGDQSNKTVY GTPHFYYVKG DADKDGSYSP TALGGNLTLS DDFYDDYHIF GINWYPDKIE
     WYVDGIVYNT MYLTGDERLE AAAAAFNKPQ YLQFNLATGG NWSKNAGYYL ASDETAFVID
     YVRYYQDAEQ KAASEAYYAS QPDLKGVKDL TMLEGTSPDL AQAVTTDQEG YVVDFSVENE
     YLFTNKGGNT NAALQAAGRD DLSALSELAP GIYNIYYSAV PYNADLGSTV TPTAKIAREV
     AILTVLPKEG LIGKKGEPLS TVALPANWQW VTPEEILGSA EHYQIKYTTE GGRAIYTSIE
     ASYISDQPIS DQASILVDLG NAILDATAEK AAVTDDEALS KLDDVMSLNQ GTVTIRYRLD
     TADTTVRSSS PLALLSISNQ ASANEYASFF IEPKNNKIGL EFKGAEVPIV KVGSGFNLLT
     NSDWQTISYV FTGSRLKIYL NGDLYGEADF AGFMKQLPWK ASADTLTIGG LKRTYDGESV
     LHWGLKGLVD QVLIDTDVYD LTDIAKAHQS TLRPVTGEKT NVWDKYDEGV FEYRIPSVVK
     TPSGTLIAAA DARKKHYNDW GDVATVVRIS HDDGKTWSNN ITVLDMPTQP YFTTQYSLAD
     WNTNMTQSAF SIDSTLLTDA SGKLYLLVDV FPESQGAVAS KAGSGYELIN GQYYLNLYDF
     DNNKYTVREG GIVYDQNGHQ TDMYVDEGNF ETAFSTRGNL YQTEAGEDIL LGNIYLRSGR
     TKQGITREGS QTAPLFTYMT SFLWLLTSED EGQTWSTPLD ITPQIKEDWM GFLGTGAAAG
     IEIDAVNAEG EQVKRLVFPI YYTNQQNATS ASLGRQSSAN IFSDDGGQTW QRGESPNDGR
     IYGHNQQTTS KDFDTSVTEL TENQIIQLNN GHLLQFMRNT GKTIVIARST DYGATWEDNP
     TVTDLPEPYV NLSAIHMMVD GKEYVVLSNP LGEPSGEQLT IRNQRMKGIL RVGEVLEDDS
     INWVASTIFE PKRFAYSSLV QLDDERVGLL YEYSGQITYS TFNIKQMISD QFREDKAEIE
     EVTITSAAPK QNGKASITIQ MTFNQPMFIL GDRQLAVTVN GVDKLASYVS GDGTDTAIFE
     LSLESMPEGP ITVLPQFDHT IVETKYGIRL TDDKAYTVSY PAAVTA
//