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C0MC89

- PUR9_STRS7

UniProt

C0MC89 - PUR9_STRS7

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Streptococcus equi subsp. zooepidemicus (strain H70)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciSEQU40041:GC8B-51-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:SZO_00300
    OrganismiStreptococcus equi subsp. zooepidemicus (strain H70)
    Taxonomic identifieri553483 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001368: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Bifunctional purine biosynthesis protein PurHPRO_1000203254Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi553483.SZO_00300.

    Structurei

    3D structure databases

    ProteinModelPortaliC0MC89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiGIGQADN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0MC89-1 [UniParc]FASTAAdd to Basket

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    MTKRALISVS DKRGIVDLAR ELKHLGWDII STGGTRLALE EAGVVTVAID    50
    DVTGFPEMMD GRVKTLHPLI HGGLLARRDI EHHLQAAKQN RIELIDLVVV 100
    NLYPFKETIC RSDITYDVAV DMVDIGGPSL LRSAAKNHAS VTVVVDPTDY 150
    PLVLGELAST GSTSYQTRQS LAAKAFRHTA AYDAVIADYF TRQAGETKPE 200
    KLTLTYDLKQ SMRYGENPQQ AADFYQRALP ITYSIASAKQ LNGKELSFNN 250
    IRDADAAIRI IRDFKERPTV VALKHMNPCG IGQADDIETA WDFAYAADPV 300
    SIFGGIVVLN REVDLATAEK LHAIFLELII APSYSKEALA VLTHKKKHLR 350
    ILELPFAAQE ASEIEAEYTG VLGGLLVQNQ DVVTESPADW IVVTKRQPNE 400
    QEMAALAFAW KTIKYVKSNA IIIANDHMTL GVGPGQTNRI ASVRIAIAQA 450
    TGQLEGAVLA SDAFFPFADS IEEIAAAGIK AIIQPGGSIR DSESIAAADQ 500
    HGITMIFTGV RHFRH 515
    Length:515
    Mass (Da):56,190
    Last modified:May 5, 2009 - v1
    Checksum:i2FCCDC550BD2E9C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204884 Genomic DNA. Translation: CAW97607.1.
    RefSeqiYP_002743595.1. NC_012470.1.

    Genome annotation databases

    EnsemblBacteriaiCAW97607; CAW97607; SZO_00300.
    GeneIDi7693855.
    KEGGiseq:SZO_00300.
    PATRICi19649568. VBIStrEqu35012_0029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204884 Genomic DNA. Translation: CAW97607.1 .
    RefSeqi YP_002743595.1. NC_012470.1.

    3D structure databases

    ProteinModelPortali C0MC89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 553483.SZO_00300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW97607 ; CAW97607 ; SZO_00300 .
    GeneIDi 7693855.
    KEGGi seq:SZO_00300.
    PATRICi 19649568. VBIStrEqu35012_0029.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi GIGQADN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci SEQU40041:GC8B-51-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H70.

    Entry informationi

    Entry nameiPUR9_STRS7
    AccessioniPrimary (citable) accession number: C0MC89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3