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C0MC14

- C0MC14_STRE4

UniProt

C0MC14 - C0MC14_STRE4

Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorUniRule annotation
    Metal bindingi143 – 1431ZincUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi85 – 884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSEQU553482:GJOY-1155-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:SEQ_1160Imported
    OrganismiStreptococcus equi subsp. equi (strain 4047)Imported
    Taxonomic identifieri553482 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001365: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi553482.SEQ_1160.

    Structurei

    3D structure databases

    ProteinModelPortaliC0MC14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiELKTVCH.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0MC14-1 [UniParc]FASTAAdd to Basket

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    MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDGFGIVS    50
    SRIGMRREAV PISNDMDIFA FIAELQEKPY CVLIDECQFL SKQNVYDLAR 100
    VVDELNVPVM AFGLKNDFQN ELFEGSKYLL LLADKIDEIK TICQYCSKKA 150
    TMVLRTEHGK PVYEGAQIQI GGNETYIPVC RKHYFHPPI 189
    Length:189
    Mass (Da):21,530
    Last modified:May 5, 2009 - v1
    Checksum:iE7C231CF85E602D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204883 Genomic DNA. Translation: CAW93850.1.
    RefSeqiYP_002746463.1. NC_012471.1.

    Genome annotation databases

    EnsemblBacteriaiCAW93850; CAW93850; SEQ_1160.
    GeneIDi7696103.
    KEGGiseu:SEQ_1160.
    PATRICi19647120. VBIStrEqu13040_1180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204883 Genomic DNA. Translation: CAW93850.1 .
    RefSeqi YP_002746463.1. NC_012471.1.

    3D structure databases

    ProteinModelPortali C0MC14.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 553482.SEQ_1160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW93850 ; CAW93850 ; SEQ_1160 .
    GeneIDi 7696103.
    KEGGi seu:SEQ_1160.
    PATRICi 19647120. VBIStrEqu13040_1180.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi ELKTVCH.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci SEQU553482:GJOY-1155-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 4047Imported.

    Entry informationi

    Entry nameiC0MC14_STRE4
    AccessioniPrimary (citable) accession number: C0MC14
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3