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C0MB61

- PUR9_STRE4

UniProt

C0MB61 - PUR9_STRE4

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, SEQ_0030
Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSEQU553482:GJOY-50-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SEQ_0030
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001365: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122972Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi553482.SEQ_0030.

Structurei

3D structure databases

ProteinModelPortaliC0MB61.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C0MB61-1 [UniParc]FASTAAdd to Basket

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MTKRALISVS DKRGIVDLAR ELKHLGWDII STGGTRLALE EAGVVTVAID    50
DVTGFPEMMD GRVKTLHPLI HGGLLARRDI EHHLQAAKQN RIELIDLVVV 100
NLYPFKETIC RPDVTYDVAV DMVDIGGPSL LRSAAKNHAS VTVVVDPTDY 150
PLVLGELAST GSTSYQTRQS LAAKAFRHTA AYDAVIADYF TRQAGETKPE 200
KLTLTYDLKQ SMRYGENPQQ AADFYQRALP TTYSIASAKQ LNGKELSFNN 250
IRDADAAIRI IRDFKERPTV VALKHMNPCG IGQADDIETA WDFAYAADPV 300
SIFGGIVVLN REVDLATAEK LHAIFLELII APGYSKEALA VLTHKKKHLR 350
ILELPFAAQE ASEIEAEYTG VLGGLLVQNQ DVVTESPADW IVVTKRQPNE 400
QEMAALAFAW KTIKYVKSNA IVIANDHMTL GVGPGQTNRI ASIRIAIAQA 450
TGQLEGAVLA SDAFFPFADS IEEIAAAGIK AIIQPGGSIR DSESIAAANQ 500
HGITMIFTGV RHFRH 515
Length:515
Mass (Da):56,143
Last modified:May 5, 2009 - v1
Checksum:i60FE4C3505588A5D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM204883 Genomic DNA. Translation: CAW91925.1.
RefSeqiYP_002745463.1. NC_012471.1.

Genome annotation databases

EnsemblBacteriaiCAW91925; CAW91925; SEQ_0030.
GeneIDi7697446.
KEGGiseu:SEQ_0030.
PATRICi19644768. VBIStrEqu13040_0029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM204883 Genomic DNA. Translation: CAW91925.1 .
RefSeqi YP_002745463.1. NC_012471.1.

3D structure databases

ProteinModelPortali C0MB61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 553482.SEQ_0030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW91925 ; CAW91925 ; SEQ_0030 .
GeneIDi 7697446.
KEGGi seu:SEQ_0030.
PATRICi 19644768. VBIStrEqu13040_0029.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SEQU553482:GJOY-50-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4047.

Entry informationi

Entry nameiPUR9_STRE4
AccessioniPrimary (citable) accession number: C0MB61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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