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C0M9N3

- FTHS_STRE4

UniProt

C0M9N3 - FTHS_STRE4

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEQU553482:GJOY-1075-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SEQ_1075
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001365: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000185264Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi553482.SEQ_1075.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0M9N3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEIAQS VPLKPITEIV KKVGIDADDL ELYGNYKAKL SFEKIKSVED
60 70 80 90 100
NKPGKLILVT AINPTPAGEG KSTMSIGLAD ALTKIGKKTM LALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTAHNAL SALIDNHLQQ
160 170 180 190 200
GNELGIDPRR IIWKRVLDLN DRSLRQVIVG LGSPVNGVPR EDGFDITVAS
210 220 230 240 250
EVMAILCLAT DLKDLKARLA NIVIAYRYDK SPVYVRDLKV EGALALILKD
260 270 280 290 300
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LNIKTPNLPK APDAVVIVAT LRALKMHGGV AKADLTFENT
360 370 380 390 400
AAVRSGFANL KRHVENIRKF NIPIVVAINE FVTDTKAEIQ VLKELCAEIA
410 420 430 440 450
VPVELASVWA KGADGGIALA NAVVKAITEE SAAYKRLYAD KDSLEEKLKA
460 470 480 490 500
IVTEIYGGRA VQFGPKAKNQ LKQFAQFGWD QLPVCMAKTQ YSFSDDPSLL
510 520 530 540 550
GAPDQFDITI RELVPKTGAG FIVALTGDVM TMPGLPKIPA AMKMDVTEDG

TAVGLF
Length:556
Mass (Da):59,518
Last modified:May 5, 2009 - v1
Checksum:i436B91F0DFFEEE9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA. Translation: CAW93710.1.
RefSeqiWP_012679495.1. NC_012471.1.
YP_002746392.1. NC_012471.1.

Genome annotation databases

EnsemblBacteriaiCAW93710; CAW93710; SEQ_1075.
GeneIDi7696830.
KEGGiseu:SEQ_1075.
PATRICi19646947. VBIStrEqu13040_1094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA. Translation: CAW93710.1 .
RefSeqi WP_012679495.1. NC_012471.1.
YP_002746392.1. NC_012471.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 553482.SEQ_1075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW93710 ; CAW93710 ; SEQ_1075 .
GeneIDi 7696830.
KEGGi seu:SEQ_1075.
PATRICi 19646947. VBIStrEqu13040_1094.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SEQU553482:GJOY-1075-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4047.

Entry informationi

Entry nameiFTHS_STRE4
AccessioniPrimary (citable) accession number: C0M9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3