Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C0M9N3

- FTHS_STRE4

UniProt

C0M9N3 - FTHS_STRE4

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSEQU553482:GJOY-1075-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SEQ_1075
    OrganismiStreptococcus equi subsp. equi (strain 4047)
    Taxonomic identifieri553482 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001365: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000185264Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi553482.SEQ_1075.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0M9N3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSDIEIAQS VPLKPITEIV KKVGIDADDL ELYGNYKAKL SFEKIKSVED    50
    NKPGKLILVT AINPTPAGEG KSTMSIGLAD ALTKIGKKTM LALREPSLGP 100
    VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTAHNAL SALIDNHLQQ 150
    GNELGIDPRR IIWKRVLDLN DRSLRQVIVG LGSPVNGVPR EDGFDITVAS 200
    EVMAILCLAT DLKDLKARLA NIVIAYRYDK SPVYVRDLKV EGALALILKD 250
    AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 300
    FGADLGAEKF LNIKTPNLPK APDAVVIVAT LRALKMHGGV AKADLTFENT 350
    AAVRSGFANL KRHVENIRKF NIPIVVAINE FVTDTKAEIQ VLKELCAEIA 400
    VPVELASVWA KGADGGIALA NAVVKAITEE SAAYKRLYAD KDSLEEKLKA 450
    IVTEIYGGRA VQFGPKAKNQ LKQFAQFGWD QLPVCMAKTQ YSFSDDPSLL 500
    GAPDQFDITI RELVPKTGAG FIVALTGDVM TMPGLPKIPA AMKMDVTEDG 550
    TAVGLF 556
    Length:556
    Mass (Da):59,518
    Last modified:May 5, 2009 - v1
    Checksum:i436B91F0DFFEEE9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204883 Genomic DNA. Translation: CAW93710.1.
    RefSeqiYP_002746392.1. NC_012471.1.

    Genome annotation databases

    EnsemblBacteriaiCAW93710; CAW93710; SEQ_1075.
    GeneIDi7696830.
    KEGGiseu:SEQ_1075.
    PATRICi19646947. VBIStrEqu13040_1094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204883 Genomic DNA. Translation: CAW93710.1 .
    RefSeqi YP_002746392.1. NC_012471.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 553482.SEQ_1075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW93710 ; CAW93710 ; SEQ_1075 .
    GeneIDi 7696830.
    KEGGi seu:SEQ_1075.
    PATRICi 19646947. VBIStrEqu13040_1094.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SEQU553482:GJOY-1075-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 4047.

    Entry informationi

    Entry nameiFTHS_STRE4
    AccessioniPrimary (citable) accession number: C0M9N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3