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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SEQ_1075
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001365 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001852641 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiC0M9N3

Structurei

3D structure databases

SMRiC0M9N3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

C0M9N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIAQS VPLKPITEIV KKVGIDADDL ELYGNYKAKL SFEKIKSVED
60 70 80 90 100
NKPGKLILVT AINPTPAGEG KSTMSIGLAD ALTKIGKKTM LALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTAHNAL SALIDNHLQQ
160 170 180 190 200
GNELGIDPRR IIWKRVLDLN DRSLRQVIVG LGSPVNGVPR EDGFDITVAS
210 220 230 240 250
EVMAILCLAT DLKDLKARLA NIVIAYRYDK SPVYVRDLKV EGALALILKD
260 270 280 290 300
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LNIKTPNLPK APDAVVIVAT LRALKMHGGV AKADLTFENT
360 370 380 390 400
AAVRSGFANL KRHVENIRKF NIPIVVAINE FVTDTKAEIQ VLKELCAEIA
410 420 430 440 450
VPVELASVWA KGADGGIALA NAVVKAITEE SAAYKRLYAD KDSLEEKLKA
460 470 480 490 500
IVTEIYGGRA VQFGPKAKNQ LKQFAQFGWD QLPVCMAKTQ YSFSDDPSLL
510 520 530 540 550
GAPDQFDITI RELVPKTGAG FIVALTGDVM TMPGLPKIPA AMKMDVTEDG

TAVGLF
Length:556
Mass (Da):59,518
Last modified:May 5, 2009 - v1
Checksum:i436B91F0DFFEEE9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA Translation: CAW93710.1
RefSeqiWP_012679495.1, NC_012471.1

Genome annotation databases

EnsemblBacteriaiCAW93710; CAW93710; SEQ_1075
KEGGiseu:SEQ_1075

Similar proteinsi

Entry informationi

Entry nameiFTHS_STRE4
AccessioniPrimary (citable) accession number: C0M9N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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