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C0M954 (C0M954_STRE4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Ordered Locus Names:SEQ_0667
OrganismStreptococcus equi subsp. equi (strain 4047) [Complete proteome] [HAMAP]
Taxonomic identifier553482 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. RuleBase RU004136

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. RuleBase RU004136

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. RuleBase RU004136

Subcellular location

Cytoplasm By similarity RuleBase RU004136.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
C0M954 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: F310BFD816C82472

FASTA46151,000
        10         20         30         40         50         60 
MKLTLHEVAR VVDAQNSLSD LDDVPLNQIE FDSRNITKGD LFLPLQGERD GHDFIDLAFE 

        70         80         90        100        110        120 
NGAVATFSER AISGRPYILV ENCLAAFQKL AQYYIDKLRV DVIAVTGSNG KTSTKDMIEA 

       130        140        150        160        170        180 
VLAKAYKTYK TQGNYNNDIG LPYTVLHMPE DTEKIVLEMG QDHMGDIQLL SRIARPHIAL 

       190        200        210        220        230        240 
LTLIGEAHLA YFGSREKIAE GKMQIVDGMD SNGILIAPGD PILDPYLPDS QMVIRFGDHQ 

       250        260        270        280        290        300 
ELVVEDIKEC KDSLTFRTNV LPRPVTLPLT GKYNATNAMI AAYVGKLLAV PDEDIIEALE 

       310        320        330        340        350        360 
TVKLTRHRTE WVKAANGADL LADVYNANPT AMRLILETFA AIPANPNGKK IAVLADMKEL 

       370        380        390        400        410        420 
GADSVALHSQ LITSLDPKRI DQLVFYGDDI QALAKLASQD YPSGRVSFFK KNNREDQYED 

       430        440        450        460 
MCQYLLTILE PNDQMLLKGS HSMLLANVVD RLTAPHAGKS S

« Hide

References

[1]"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens."
Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A. expand/collapse author list , Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J., Waller A.S.
PLoS Pathog. 5:E1000346-E1000346(2009) [PubMed: 19325880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM204883 Genomic DNA. Translation: CAW93001.1.
RefSeqYP_002746019.1. NC_012471.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC0M954.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000067703; EBSTRP00000063037; EBSTRG00000068536.
GeneID7695654.
GenomeReviewsGene locus SEQ_0667 in contig FM204883_GR.
KEGGseu:SEQ_0667.
PATRIC19646115. VBIStrEqu13040_0681.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027197.
OMAYAVIEMG.
ProtClustDBCLSK876736.

Family and domain databases

InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
KOK01929.
PANTHERPTHR23135:SF3. MurF. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. MurF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0M954_STRE4
AccessionPrimary (citable) accession number: C0M954
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info