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C0M913

- PNP_STRE4

UniProt

C0M913 - PNP_STRE4

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891MagnesiumUniRule annotation
Metal bindingi495 – 4951MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSEQU553482:GJOY-2005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:SEQ_1995
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001365: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Polyribonucleotide nucleotidyltransferasePRO_1000185752Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi553482.SEQ_1995.

Structurei

3D structure databases

ProteinModelPortaliC0M913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61560KHUniRule annotationAdd
BLAST
Domaini625 – 69369S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0M913-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQTFTTTF AGKPLVVEVG QVAKRANGAT VVRYGESTVL TAAVMSKKMS
60 70 80 90 100
TGDFFPLQVN YEEKMYAAGK FPGGWMKREG RPSTDATLTA RLIDRPIRPM
110 120 130 140 150
FAEGFRNEVQ VINTVLSYDE DASAPMAAML GSSLALSISD IPFNGPIAGV
160 170 180 190 200
QVAYVEGEFI INPDKAQQEA SLLELTVAGT KDAINMVESG AKELPEAIML
210 220 230 240 250
EALLVGHKAI QELIAFQEEI VAAVGKEKAE VELLQVAADL QAEIIETYNA
260 270 280 290 300
DLQQAIQVEE KKAREAATEA VKERVIAAYE ERYAADEEHD RIMRDVAEIL
310 320 330 340 350
EQMEHAEVRR LITEDKVRPD GRRVDEIRPL AAEIDFLPRV HGSGLFTRGQ
360 370 380 390 400
TQALSVLTLA PMGDTQIIDG LEPEYKKRFL HHYNFPQYSV GETGRYGAAG
410 420 430 440 450
RREIGHGALG ERALAQVLPS LEAFPYAIRL VAEVLESNGS SSQASICAGT
460 470 480 490 500
LALMAAGVPI KAPVAGIAMG LISDGTNYTV LTDIQGLEDH FGDMDFKVAG
510 520 530 540 550
TRQGITALQM DIKIEGITPQ ILEEALAQAK KARFEILDLI EATIAEPRPE
560 570 580 590 600
LAPTAPKIDT IKIDVDKIKV VIGKGGETID KIIAETGVKI DIDEEGNVSI
610 620 630 640 650
YSSDQDAINR AKEIIASLVR EAKVGEVYHA KVVRIEKFGA FVNLFDKTDA
660 670 680 690 700
LVHISEIAWS RTTNVSDVLE IGEEVDVKVI KVDDKGRIDA SMKALVPRPP
710
KPEKSEAKKE GKHD
Length:714
Mass (Da):77,771
Last modified:May 5, 2009 - v1
Checksum:i4E95841604BE2BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA. Translation: CAW95251.1.
RefSeqiWP_012680145.1. NC_012471.1.
YP_002747212.1. NC_012471.1.

Genome annotation databases

EnsemblBacteriaiCAW95251; CAW95251; SEQ_1995.
GeneIDi7696264.
KEGGiseu:SEQ_1995.
PATRICi19648940. VBIStrEqu13040_2045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA. Translation: CAW95251.1 .
RefSeqi WP_012680145.1. NC_012471.1.
YP_002747212.1. NC_012471.1.

3D structure databases

ProteinModelPortali C0M913.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 553482.SEQ_1995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW95251 ; CAW95251 ; SEQ_1995 .
GeneIDi 7696264.
KEGGi seu:SEQ_1995.
PATRICi 19648940. VBIStrEqu13040_2045.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci SEQU553482:GJOY-2005-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4047.

Entry informationi

Entry nameiPNP_STRE4
AccessioniPrimary (citable) accession number: C0M913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3