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C0M8N3

- SYL_STRE4

UniProt

C0M8N3 - SYL_STRE4

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Protein
Leucine--tRNA ligase
Gene
leuS, SEQ_0234
Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei613 – 6131ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEQU553482:GJOY-263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SEQ_0234
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001365: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Leucine--tRNA ligaseUniRule annotation
PRO_1000199224Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi553482.SEQ_0234.

Structurei

3D structure databases

ProteinModelPortaliC0M8N3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionUniRule annotation
Add
BLAST
Motifi610 – 6145"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0M8N3-1 [UniParc]FASTAAdd to Basket

« Hide

MTFYNHKAIE PKWQAFWADN HTFKTGTDAS KPKFYALDMF PYPSGAGLHV    50
GHPEGYTATD ILSRFKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPAEF 100
TAENIANFKR QINALGFSYD WDREINTTDP SYYKWTQWIF TKLYEKGLAY 150
EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA 200
ERLLADLEEV DWPESIKDMQ RNWIGKSTGA NVTFKVKDTD KDFTVFTTRP 250
DTLFGATYAV LAPEHALVDS ITTAEQAQAV AEYKRQASLK SDLARTDLAK 300
EKTGVWTGAY AINPVNGKEM PIWIADYVLA SYGTGAIMAV PAHDERDWAF 350
AKQFNLEIIP VLEGGNVDEA AYTEDGIHIN SDFLDGLDKA CAIAKMVAWL 400
EETGVGHEKV SYRLRDWLFS RQRYWGEPIP IIHWEDGTST AVPEQDLPLV 450
LPVTKDIRPS GTGESPLANL TDWLEVTRED GVKGRRETNT MPQWAGSSWY 500
YLRYIDPHND EQLADKDLLK QWLPVDIYIG GAEHAVLHLL YARFWHKVLY 550
DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVDK RDGSFFHMET 600
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS 650
EEGLEGARKF LDRVYRLITT KEIVAENSGA LDKAYHETVK AVTEQIEGMK 700
FNTAIAQLMI FVNAANKEDE LYVAYAKGFV QLLAPFAPHL GEELWQILTA 750
SGQSISYVAW PTHDDSKLVE NDVEIVVQIK GKVKAKLVVA KDLSREELEK 800
VALAHDKIQA EIAGKEVAKV IVVPNKLVNI VVK 833
Length:833
Mass (Da):93,821
Last modified:May 5, 2009 - v1
Checksum:i252AEEEE93362381
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM204883 Genomic DNA. Translation: CAW92273.1.
RefSeqiWP_012678913.1. NC_012471.1.
YP_002745647.1. NC_012471.1.

Genome annotation databases

EnsemblBacteriaiCAW92273; CAW92273; SEQ_0234.
GeneIDi7696632.
KEGGiseu:SEQ_0234.
PATRICi19645191. VBIStrEqu13040_0222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM204883 Genomic DNA. Translation: CAW92273.1 .
RefSeqi WP_012678913.1. NC_012471.1.
YP_002745647.1. NC_012471.1.

3D structure databases

ProteinModelPortali C0M8N3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 553482.SEQ_0234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW92273 ; CAW92273 ; SEQ_0234 .
GeneIDi 7696632.
KEGGi seu:SEQ_0234.
PATRICi 19645191. VBIStrEqu13040_0222.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SEQU553482:GJOY-263-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4047.

Entry informationi

Entry nameiSYL_STRE4
AccessioniPrimary (citable) accession number: C0M8N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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