C0M8H8 (MSRB_STRE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	SEQ_1377

Organism

Streptococcus equi subsp. equi (strain 4047) [Complete proteome] [HAMAP]

Taxonomic identifier

553482 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000184554
Sites
	Active site	116	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0M8H8 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 51ABB3E90B742040	FASTA	145	16,407
	10 20 30 40 50 60 MESKEELRQR IGDLAFEVTQ HAATERAFTG QYDDFFEKGI YVDVVSGEVL FSSLDKFNSG 70 80 90 100 110 120 CGWPAFSKPI QHRMVTNHHD SSHGMRRVEV KSREAGSHLG HVFNDGPKEA GGLRYCINSA 130 140 ALKFIPYDQM EQEGYAEWLG IFDKS

References

[1]

"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens." Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A. , Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J., Waller A.S. PLoS Pathog. 5:E1000346-E1000346(2009) [PubMed: 19325880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 4047.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM204883 Genomic DNA. Translation: CAW94211.1.
RefSeq	YP_002746654.1. NC_012471.1.
3D structure databases
ProteinModelPortal	C0M8H8.
ModBase	Search...
Protein-protein interaction databases
STRING	C0M8H8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000066760; EBSTRP00000063717; EBSTRG00000067666.
GeneID	7695335.
GenomeReviews	Gene locus SEQ_1377 in contig FM204883_GR.
KEGG	seu:SEQ_1377.
PATRIC	19647558. VBIStrEqu13040_1395.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027538.
OMA	DSSHGMR.
ProtClustDB	PRK00222.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_STRE4

Accession

Primary (citable) accession number: C0M8H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program