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C0M812 (C0M812_STRE4) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der HAMAP-Rule MF_00195 RuleBase RU004481
Alternative name(s):
GTP-binding protein EngA HAMAP-Rule MF_00195
Gene names
Name:der HAMAP-Rule MF_00195
Ordered Locus Names:SEQ_1885
OrganismStreptococcus equi subsp. equi (strain 4047) [Complete proteome] [HAMAP]
Taxonomic identifier553482 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP-Rule MF_00195 RuleBase RU004481

Subunit structure

Associates with the 50S ribosomal subunit By similarity. HAMAP-Rule MF_00195

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily. HAMAP-Rule MF_00195 RuleBase RU004481

Contains 1 KH-like domain. HAMAP-Rule MF_00195 SAAS SAAS016484

Contains 2 G (guanine nucleotide-binding) domains. HAMAP-Rule MF_00195 SAAS SAAS016484

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain16 – 130115G 1 By similarity HAMAP-Rule MF_00195
Domain187 – 305119G 2 By similarity HAMAP-Rule MF_00195
Nucleotide binding20 – 278GTP 1 By similarity HAMAP-Rule MF_00195
Nucleotide binding67 – 715GTP 1 By similarity HAMAP-Rule MF_00195
Nucleotide binding129 – 1324GTP 1 By similarity HAMAP-Rule MF_00195
Nucleotide binding191 – 1988GTP 2 By similarity HAMAP-Rule MF_00195
Nucleotide binding239 – 2435GTP 2 By similarity HAMAP-Rule MF_00195
Nucleotide binding304 – 3074GTP 2 By similarity HAMAP-Rule MF_00195

Sequences

Sequence LengthMass (Da)Tools
C0M812 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 34CCEBE0AF83A316

FASTA44650,112
        10         20         30         40         50         60 
MDNEIKKRRI MVLPTVAIVG RPNVGKSTLF NRIAGERISI VEDVEGVTRD RIYTTGEWLN 

        70         80         90        100        110        120 
RQFSLIDTGG IDDVDAPFME QIKHQAHIAM DEADVIVFVV SGKEGVTDAD EYVSKLLYRT 

       130        140        150        160        170        180 
NKPVILVVNK VDNPEMRNDI YDFYSLGLGD SFPVSSVHGI GTGDVLDAII DNLPIEEPVE 

       190        200        210        220        230        240 
NDDVIRFSLI GRPNVGKSSL INAILGEERV IASPVAGTTR DAIDTSFTDE SGQAYTMIDT 

       250        260        270        280        290        300 
AGMRKSGKVY ENTEKYSVMR AMRAIDRSDI VLMVINAEEG IRDYDKRIAG FAHEAGKGMI 

       310        320        330        340        350        360 
IVVNKWDTIE KDNHTVARWE ADIRDQFQFL TYAPIIFVSA VTKQRLNRLP ELIKRISDSQ 

       370        380        390        400        410        420 
SQRISSAILN DVIMDAIAIN PTPTDKGRRL KIFYATQVSV KPPTFVVFVN EEELMHFSYL 

       430        440 
RFLENQIRAA FTFEGTPIKL IARNRK

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References

[1]"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens."
Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A. expand/collapse author list , Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J., Waller A.S.
PLoS Pathog. 5:e1000346-e1000346(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 4047.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM204883 Genomic DNA. Translation: CAW95070.1.
RefSeqYP_002747111.1. NC_012471.1.

3D structure databases

ProteinModelPortalC0M812.
ModBaseSearch...

Protein-protein interaction databases

STRING553482.SEQ_1885.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAW95070; CAW95070; SEQ_1885.
GeneID7695996.
KEGGseu:SEQ_1885.
PATRIC19648658. VBIStrEqu13040_1931.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1160.
HOGENOMHOG000242861.
KOK03977.
OMAYLENTYR.
ProtClustDBPRK00093.

Enzyme and pathway databases

BioCycSEQU553482:GJOY-1874-MONOMER.

Family and domain databases

Gene3D3.30.300.20. 1 hit.
HAMAPMF_00195. GTPase_Der.
InterProIPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameC0M812_STRE4
AccessionPrimary (citable) accession number: C0M812
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info