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C0M780 (FMT_STRE4) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase

EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:SEQ_1777
OrganismStreptococcus equi subsp. equi (strain 4047) [Complete proteome] [HAMAP]
Taxonomic identifier553482 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_1000190042

Regions

Region110 – 1134Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
C0M780 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 672A0155AD01DCAE

FASTA31133,366
        10         20         30         40         50         60 
MTRLIFMGTP QFSATVLQGL LEKPAYDILA VVTQPDRAVG RKKDITMTPV KKLALAHQLP 

        70         80         90        100        110        120 
VFQPEKLSGS QELADIMALG ADGIVTAAFG QFLPTVLLDS VTFAVNVHAS LLPKYRGGAP 

       130        140        150        160        170        180 
IHYAIINGDK EAGVTIMEMV KEMDAGDMIS SASLPILDTD NVGTMFDKLA ILGRDLLLKT 

       190        200        210        220        230        240 
LPDYLSGDLK PVPQDHSQAT FSPNLSAEEE RLDWSKPARE VFNHIRGMNP WPVAHTLLDG 

       250        260        270        280        290        300 
QRFKIYEAEL AEGSGSAGQI IAKTKKALVV AAGEGALSLT LVQPAGKPKM PIVDFLNGIG 

       310 
RSLEVGDVLG E 

« Hide

References

[1]"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens."
Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F., Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M., Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A. expand/collapse author list , Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C., Maskell D.J., Parkhill J., Waller A.S.
PLoS Pathog. 5:E1000346-E1000346(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 4047.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM204883 Genomic DNA. Translation: CAW94890.1.
RefSeqYP_002747012.1. NC_012471.1.

3D structure databases

ProteinModelPortalC0M780.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING553482.SEQ_1777.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAW94890; CAW94890; SEQ_1777.
GeneID7695701.
KEGGseu:SEQ_1777.
PATRIC19648432. VBIStrEqu13040_1819.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0223.
HOGENOMHOG000261177.
KOK00604.
OMAFDKITPK.
OrthoDBEOG6B09WV.
ProtClustDBPRK00005.

Enzyme and pathway databases

BioCycSEQU553482:GJOY-1770-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
PROSITEPS00373. GART. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFMT_STRE4
AccessionPrimary (citable) accession number: C0M780
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families