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C0M6X6

- ACKA_STRE4

UniProt

C0M6X6 - ACKA_STRE4

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Protein

Acetate kinase

Gene

ackA

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81MagnesiumUniRule annotation
Binding sitei15 – 151ATPUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Active sitei146 – 1461Proton donor/acceptorUniRule annotation
Sitei178 – 1781Transition state stabilizerUniRule annotation
Sitei239 – 2391Transition state stabilizerUniRule annotation
Metal bindingi383 – 3831MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2105ATPUniRule annotation
Nucleotide bindingi283 – 2853ATPUniRule annotation
Nucleotide bindingi331 – 3355ATPUniRule annotation

GO - Molecular functioni

  1. acetate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEQU553482:GJOY-150-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:SEQ_0118
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001365: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Acetate kinasePRO_1000116809Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi553482.SEQ_0118.

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKYVTQRA.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0M6X6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKTIAINAG SSSLKWQLYQ MPEEKVLAQG IIERIGLTDS ISTVKYDGKK
60 70 80 90 100
EEHILDIPDH TEAVKRLLND LIHFGIIGTY DEITGVGHRI VAGGEYFKES
110 120 130 140 150
VVVDDKVVEQ VEELAALAPL HNPGAAAGIR AFRKILPDIT SVCVFDTSFH
160 170 180 190 200
TTMQKHTYLY PIPQKYYTDY KVRKYGAHGT SHKYVAEEAA KMLGRPLDEL
210 220 230 240 250
KLITAHVGNG VSITANYHGQ SVDTSMGFTP LAGPMMGTRS GDIDPAIIPY
260 270 280 290 300
LIAQDPELKD AADVVNMLNK QSGLGGVSGI SSDMRDIEAG LQANNPDAVL
310 320 330 340 350
AYNIFIDRIK KFIGQYFAVL NGADALVFTA GMGENAPLMR QDVVNGLSWF
360 370 380 390
GMEIDPEKNV FGYRGDISTA ASKVKVLVIS TDEELCIARD VERLKQTIS
Length:399
Mass (Da):43,597
Last modified:May 5, 2009 - v1
Checksum:i3B381D6811DCF126
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM204883 Genomic DNA. Translation: CAW92072.1.
RefSeqiWP_012678817.1. NC_012471.1.
YP_002745538.1. NC_012471.1.

Genome annotation databases

EnsemblBacteriaiCAW92072; CAW92072; SEQ_0118.
GeneIDi7695550.
KEGGiseu:SEQ_0118.
PATRICi19644975. VBIStrEqu13040_0115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM204883 Genomic DNA. Translation: CAW92072.1 .
RefSeqi WP_012678817.1. NC_012471.1.
YP_002745538.1. NC_012471.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 553482.SEQ_0118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW92072 ; CAW92072 ; SEQ_0118 .
GeneIDi 7695550.
KEGGi seu:SEQ_0118.
PATRICi 19644975. VBIStrEqu13040_0115.

Phylogenomic databases

eggNOGi COG0282.
HOGENOMi HOG000288398.
KOi K00925.
OMAi KYVTQRA.
OrthoDBi EOG69975F.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .
BioCyci SEQU553482:GJOY-150-MONOMER.

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4047.

Entry informationi

Entry nameiACKA_STRE4
AccessioniPrimary (citable) accession number: C0M6X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3