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Protein

Acetate kinase

Gene

ackA

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg(2+). Can also accept Mn2+.UniRule annotation

Pathway: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81MagnesiumUniRule annotation
Binding sitei15 – 151ATPUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Active sitei146 – 1461Proton donor/acceptorUniRule annotation
Sitei178 – 1781Transition state stabilizerUniRule annotation
Sitei239 – 2391Transition state stabilizerUniRule annotation
Metal bindingi383 – 3831MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2105ATPUniRule annotation
Nucleotide bindingi283 – 2853ATPUniRule annotation
Nucleotide bindingi331 – 3355ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEQU553482:GJOY-150-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:SEQ_0118
OrganismiStreptococcus equi subsp. equi (strain 4047)
Taxonomic identifieri553482 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001365 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Acetate kinasePRO_1000116809Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0M6X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTIAINAG SSSLKWQLYQ MPEEKVLAQG IIERIGLTDS ISTVKYDGKK
60 70 80 90 100
EEHILDIPDH TEAVKRLLND LIHFGIIGTY DEITGVGHRI VAGGEYFKES
110 120 130 140 150
VVVDDKVVEQ VEELAALAPL HNPGAAAGIR AFRKILPDIT SVCVFDTSFH
160 170 180 190 200
TTMQKHTYLY PIPQKYYTDY KVRKYGAHGT SHKYVAEEAA KMLGRPLDEL
210 220 230 240 250
KLITAHVGNG VSITANYHGQ SVDTSMGFTP LAGPMMGTRS GDIDPAIIPY
260 270 280 290 300
LIAQDPELKD AADVVNMLNK QSGLGGVSGI SSDMRDIEAG LQANNPDAVL
310 320 330 340 350
AYNIFIDRIK KFIGQYFAVL NGADALVFTA GMGENAPLMR QDVVNGLSWF
360 370 380 390
GMEIDPEKNV FGYRGDISTA ASKVKVLVIS TDEELCIARD VERLKQTIS
Length:399
Mass (Da):43,597
Last modified:May 5, 2009 - v1
Checksum:i3B381D6811DCF126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA. Translation: CAW92072.1.
RefSeqiWP_012678817.1. NC_012471.1.
YP_002745538.1. NC_012471.1.

Genome annotation databases

EnsemblBacteriaiCAW92072; CAW92072; SEQ_0118.
KEGGiseu:SEQ_0118.
PATRICi19644975. VBIStrEqu13040_0115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM204883 Genomic DNA. Translation: CAW92072.1.
RefSeqiWP_012678817.1. NC_012471.1.
YP_002745538.1. NC_012471.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAW92072; CAW92072; SEQ_0118.
KEGGiseu:SEQ_0118.
PATRICi19644975. VBIStrEqu13040_0115.

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.
BioCyciSEQU553482:GJOY-150-MONOMER.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4047.

Entry informationi

Entry nameiACKA_STRE4
AccessioniPrimary (citable) accession number: C0M6X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.