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C0M6X6

- ACKA_STRE4

UniProt

C0M6X6 - ACKA_STRE4

Protein

Acetate kinase

Gene

ackA

Organism
Streptococcus equi subsp. equi (strain 4047)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

    Catalytic activityi

    ATP + acetate = ADP + acetyl phosphate.UniRule annotation

    Cofactori

    Mg2+. Can also accept Mn2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81MagnesiumUniRule annotation
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei89 – 891SubstrateUniRule annotation
    Active sitei146 – 1461Proton donor/acceptorUniRule annotation
    Sitei178 – 1781Transition state stabilizerUniRule annotation
    Sitei239 – 2391Transition state stabilizerUniRule annotation
    Metal bindingi383 – 3831MagnesiumUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi206 – 2105ATPUniRule annotation
    Nucleotide bindingi283 – 2853ATPUniRule annotation
    Nucleotide bindingi331 – 3355ATPUniRule annotation

    GO - Molecular functioni

    1. acetate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    2. organic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSEQU553482:GJOY-150-MONOMER.
    UniPathwayiUPA00340; UER00458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
    Alternative name(s):
    AcetokinaseUniRule annotation
    Gene namesi
    Name:ackAUniRule annotation
    Ordered Locus Names:SEQ_0118
    OrganismiStreptococcus equi subsp. equi (strain 4047)
    Taxonomic identifieri553482 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001365: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Acetate kinasePRO_1000116809Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi553482.SEQ_0118.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0282.
    HOGENOMiHOG000288398.
    KOiK00925.
    OMAiKYVTQRA.
    OrthoDBiEOG69975F.

    Family and domain databases

    HAMAPiMF_00020. Acetate_kinase.
    InterProiIPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view]
    PANTHERiPTHR21060. PTHR21060. 1 hit.
    PfamiPF00871. Acetate_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSiPR00471. ACETATEKNASE.
    TIGRFAMsiTIGR00016. ackA. 1 hit.
    PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0M6X6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKTIAINAG SSSLKWQLYQ MPEEKVLAQG IIERIGLTDS ISTVKYDGKK    50
    EEHILDIPDH TEAVKRLLND LIHFGIIGTY DEITGVGHRI VAGGEYFKES 100
    VVVDDKVVEQ VEELAALAPL HNPGAAAGIR AFRKILPDIT SVCVFDTSFH 150
    TTMQKHTYLY PIPQKYYTDY KVRKYGAHGT SHKYVAEEAA KMLGRPLDEL 200
    KLITAHVGNG VSITANYHGQ SVDTSMGFTP LAGPMMGTRS GDIDPAIIPY 250
    LIAQDPELKD AADVVNMLNK QSGLGGVSGI SSDMRDIEAG LQANNPDAVL 300
    AYNIFIDRIK KFIGQYFAVL NGADALVFTA GMGENAPLMR QDVVNGLSWF 350
    GMEIDPEKNV FGYRGDISTA ASKVKVLVIS TDEELCIARD VERLKQTIS 399
    Length:399
    Mass (Da):43,597
    Last modified:May 5, 2009 - v1
    Checksum:i3B381D6811DCF126
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204883 Genomic DNA. Translation: CAW92072.1.
    RefSeqiWP_012678817.1. NC_012471.1.
    YP_002745538.1. NC_012471.1.

    Genome annotation databases

    EnsemblBacteriaiCAW92072; CAW92072; SEQ_0118.
    GeneIDi7695550.
    KEGGiseu:SEQ_0118.
    PATRICi19644975. VBIStrEqu13040_0115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM204883 Genomic DNA. Translation: CAW92072.1 .
    RefSeqi WP_012678817.1. NC_012471.1.
    YP_002745538.1. NC_012471.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 553482.SEQ_0118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW92072 ; CAW92072 ; SEQ_0118 .
    GeneIDi 7695550.
    KEGGi seu:SEQ_0118.
    PATRICi 19644975. VBIStrEqu13040_0115.

    Phylogenomic databases

    eggNOGi COG0282.
    HOGENOMi HOG000288398.
    KOi K00925.
    OMAi KYVTQRA.
    OrthoDBi EOG69975F.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00458 .
    BioCyci SEQU553482:GJOY-150-MONOMER.

    Family and domain databases

    HAMAPi MF_00020. Acetate_kinase.
    InterProi IPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR21060. PTHR21060. 1 hit.
    Pfami PF00871. Acetate_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSi PR00471. ACETATEKNASE.
    TIGRFAMsi TIGR00016. ackA. 1 hit.
    PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 4047.

    Entry informationi

    Entry nameiACKA_STRE4
    AccessioniPrimary (citable) accession number: C0M6X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3