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Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteaseUniRule annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 117Peptidase A2InterPro annotationAdd BLAST70
Domaini171 – 361Reverse transcriptaseInterPro annotationAdd BLAST191

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom_sf.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
PfamiView protein in Pfam
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.

Sequencei

Sequence statusi: Fragment.

C0LQD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RRLGDGGGES LCTEAGAERQ GTSSSLNFPQ ITLWQRPLVT VKIGGQLKEA
60 70 80 90 100
LLDTGADDTV LEDINLPGKW KPKMIGGIGG FIKVRQYDQI QIEICGKKAI
110 120 130 140 150
GTVLVGPTPV NIIGRNMLTQ IGCTLNFPIS PIDTVPVTLK PGMDGPKVKQ
160 170 180 190 200
WPLTEEKIKA LTEICKEMEE EGKISKIGPE NPYNTPVFAI KKKDSTKWRK
210 220 230 240 250
LVDFRELNKR TQDFWEVQLG IPHPAGLKKK KSVTVLDVGD AYFSVPLDES
260 270 280 290 300
FRKYTAFTIP SINNETPGIR YQYNVLPQGW KGSPAIFQSS MTKILEPYKI
310 320 330 340 350
KNPEMVIYQY MDDLYVGSDL EIGQHRIKIE ELRAHLLSWG FTTPDKKHQK
360 370 380 390 400
EPPFLWMGYE LHPDKWTVQP IELPEKDHWT VNDIQKLVGK LNWASQIYPG
410 420 430 440 450
IKIKQLCKLL RGAKALTDII PLTEEAELEL AENREILKTP VHGVYYDPSK
460 470 480 490 500
DLVAEVQKQG QDQWTYQIYQ EPYKNLKTGK YARKRSAHTN DVRQLAEVVQ
510 520 530 540 550
KIATESIVIW GKTPKFKLPI QRETWETWWT EYWQATWIPE WEFVNTPPLV
560
KLWYQLEKDP IMGAE
Length:565
Mass (Da):64,681
Last modified:May 5, 2009 - v1
Checksum:iE31B0A5FA6C3A5D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei565Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ752417 Genomic RNA. Translation: ACN66488.1.

Similar proteinsi

Entry informationi

Entry nameiC0LQD3_9HIV1
AccessioniPrimary (citable) accession number: C0LQD3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation