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Protein

Importin subunit alpha-8

Gene

Kpna7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-8
Alternative name(s):
Karyopherin subunit alpha-7
Gene namesi
Name:Kpna7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141165 Kpna7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant mice exhibit abnormal preimplantation development. About half of the mutant embryos fail to develop into the blastocyst stage, or are delayed. Lethality is greater among female than among male embryos.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135371 – 499Importin subunit alpha-8Add BLAST499

Proteomic databases

PaxDbiC0LLJ0
PeptideAtlasiC0LLJ0
PRIDEiC0LLJ0

PTM databases

iPTMnetiC0LLJ0
PhosphoSitePlusiC0LLJ0

Expressioni

Tissue specificityi

Expressed predominantly in ovary. Isoform 1 is the predominant form.1 Publication

Developmental stagei

Expressed at high levels in germinal vesicle-stage oocytes, as well as in zygotes and 2-cell embryos (at protein level). Drastically down-regulated after the 2-cell stage.1 Publication

Gene expression databases

BgeeiENSMUSG00000038770
ExpressionAtlasiC0LLJ0 baseline and differential
GenevisibleiC0LLJ0 MM

Interactioni

Subunit structurei

Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain. This complex dissociates in the presence of RAN-GTP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106300

Structurei

3D structure databases

ProteinModelPortaliC0LLJ0
SMRiC0LLJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57IBBPROSITE-ProRule annotationAdd BLAST57
Repeati101 – 141ARM 1Add BLAST41
Repeati144 – 183ARM 2Add BLAST40
Repeati186 – 226ARM 3Add BLAST41
Repeati229 – 268ARM 4Add BLAST40
Repeati271 – 310ARM 5Add BLAST40
Repeati313 – 352ARM 6Add BLAST40
Repeati354 – 393ARM 7Add BLAST40
Repeati397 – 436ARM 8Add BLAST40

Sequence similaritiesi

Belongs to the importin alpha family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
HOGENOMiHOG000167616
HOVERGENiHBG001846
InParanoidiC0LLJ0
OMAiNKNPYPC
OrthoDBiEOG091G095Z
PhylomeDBiC0LLJ0
TreeFamiTF101178

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR000225 Armadillo
IPR002652 Importin-a_IBB
IPR036975 Importin-a_IBB_sf
IPR024931 Importing_su_alpha
PfamiView protein in Pfam
PF00514 Arm, 5 hits
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
PIRSFiPIRSF005673 Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 2 hits
PS51214 IBB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: C0LLJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSKAPKER LKNYKYRGKE MSLPRQQRIA SSLQLRKTRK DEQVLKRRNI
60 70 80 90 100
DLFSSDMVSQ ALVKEVNFTL DDIIQAVNSS DPILHFRATR AAREMISQEN
110 120 130 140 150
TPPLNLIIEA GLIPKLVDFL KATPHPKLQF EAAWVLTNIA SGTSEQTRAV
160 170 180 190 200
VKEGAIQPLI ELLCSPHLTV SEQAVWALGN IAGDCAEFRD CVISNNAIPH
210 220 230 240 250
LINLISKGIP ITFLRNISWT LSNLCRNKDP YPSESAVRQM LPPLCQLLLH
260 270 280 290 300
RDNEILADTC WALSYLTKGG KEYIHHVVTT GILPRLVELM TSSELSISIP
310 320 330 340 350
CLHTIGNIVA GTDEQTQMAI DAGMLKVLGQ VLKHPKTSIQ VLAAWTMSNV
360 370 380 390 400
AAGPRHQVEQ LLCNLLPILV DLLRNAELKV QKEVVCTVIN IATGASQDQL
410 420 430 440 450
TLLAHSGILE PMLSLLSAPD LEVVIIVLDI ISYLLQHIDN LQEKKRLYFQ
460 470 480 490
IEKFGGFEKI ECLQHHHNIS ISNSALDIIE KYFCEDGDGD SLPGPGLRV
Length:499
Mass (Da):55,458
Last modified:May 5, 2009 - v1
Checksum:i0B1094E04CAFA556
GO
Isoform 2 (identifier: C0LLJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-182: A → ADRKMPDTQVQIFTPSTREAKA

Show »
Length:520
Mass (Da):57,860
Checksum:i63A6CCCEFD6D0546
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161E → D in ACN85342 (PubMed:20699224).Curated1
Sequence conflicti161E → D in AAX50192 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041924182A → ADRKMPDTQVQIFTPSTREA KA in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ717332 mRNA Translation: ACN85341.1
FJ717333 mRNA Translation: ACN85342.1
AY950703 mRNA Translation: AAX50192.1
AC110556 Genomic DNA No translation available.
AC113295 Genomic DNA No translation available.
CH466529 Genomic DNA Translation: EDL19009.1
AK136027 mRNA Translation: BAE22781.1
CCDSiCCDS19852.1 [C0LLJ0-1]
CCDS84996.1 [C0LLJ0-2]
RefSeqiNP_001013796.2, NM_001013774.2 [C0LLJ0-1]
NP_001334460.1, NM_001347531.1 [C0LLJ0-2]
XP_017176433.1, XM_017320944.1 [C0LLJ0-1]
UniGeneiMm.332837

Genome annotation databases

EnsembliENSMUST00000110672; ENSMUSP00000106300; ENSMUSG00000038770 [C0LLJ0-1]
ENSMUST00000110673; ENSMUSP00000106301; ENSMUSG00000038770 [C0LLJ0-2]
ENSMUST00000116454; ENSMUSP00000112155; ENSMUSG00000038770 [C0LLJ0-1]
GeneIDi381686
KEGGimmu:381686
UCSCiuc009alx.1 mouse [C0LLJ0-2]
uc009aly.1 mouse [C0LLJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIMA8_MOUSE
AccessioniPrimary (citable) accession number: C0LLJ0
Secondary accession number(s): C0LLJ1, Q3UWY3, Q58HC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 5, 2009
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health