ID   C0LLI8_HUMAN            Unreviewed;       220 AA.
AC   C0LLI8;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=Estrogen receptor {ECO:0000256|ARBA:ARBA00015934};
DE   AltName: Full=ER-alpha {ECO:0000256|ARBA:ARBA00031973};
DE   AltName: Full=Estradiol receptor {ECO:0000256|ARBA:ARBA00031699};
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 1 {ECO:0000256|ARBA:ARBA00032418};
DE   Flags: Fragment;
GN   Name=ESR1 {ECO:0000313|EMBL:ACN89825.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACN89825.1};
RN   [1] {ECO:0000313|EMBL:ACN89825.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Substantia nigra {ECO:0000313|EMBL:ACN89825.1};
RX   PubMed=20417581; DOI=10.1016/j.neurobiolaging.2010.03.010;
RA   Ishunina T.A., Swaab D.F.;
RT   "Decreased alternative splicing of estrogen receptor-alpha mRNA in the
RT   Alzheimer's disease brain.";
RL   Neurobiol. Aging 33:286-296(2012).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000256|ARBA:ARBA00005413}.
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DR   EMBL; FJ716814; ACN89825.1; -; mRNA.
DR   AlphaFoldDB; C0LLI8; -.
DR   SMR; C0LLI8; -.
DR   PeptideAtlas; C0LLI8; -.
DR   ChiTaRS; ESR1; human.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 2.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092:SF16; ESTROGEN RECEPTOR; 1.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00022665};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ACN89825.1};
KW   Steroid-binding {ECO:0000256|ARBA:ARBA00022665};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          78..220
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          24..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACN89825.1"
FT   NON_TER         220
FT                   /evidence="ECO:0000313|EMBL:ACN89825.1"
SQ   SEQUENCE   220 AA;  24824 MW;  46E64AD1B165FD7C CRC64;
     RKSCQACRLR KCYEVGMMKG GIRKDRRGGR MLKHKRQRDD GEGRGEVGSA GDMRAANLWP
     SPLMIKRSKK NSLALSLTAD QMVSALLDAE PPILYSEYDP TRPFSEASMM GLLTNLADRE
     LVHMINWAKR VPGFVDLTLH DQVHLLECAW LEILMIGLVW RSMEHPGKLL FAPNLLLDSN
     KGMEHLYSMK CKNVVPLYDL LLEMLDAHRL HAPTSRGGAS
//