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C0LLI8

- C0LLI8_HUMAN

UniProt

C0LLI8 - C0LLI8_HUMAN

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Protein
Submitted name: Estrogen receptor alpha delta 6,7 isoform
Gene
ESR1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor alpha delta 6,7 isoformImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Family and domain databases

Gene3Di1.10.565.10. 3 hits.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.

Sequencei

Sequence statusi: Fragment.

C0LLI8-1 [UniParc]FASTAAdd to Basket

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RKSCQACRLR KCYEVGMMKG GIRKDRRGGR MLKHKRQRDD GEGRGEVGSA    50
GDMRAANLWP SPLMIKRSKK NSLALSLTAD QMVSALLDAE PPILYSEYDP 100
TRPFSEASMM GLLTNLADRE LVHMINWAKR VPGFVDLTLH DQVHLLECAW 150
LEILMIGLVW RSMEHPGKLL FAPNLLLDSN KGMEHLYSMK CKNVVPLYDL 200
LLEMLDAHRL HAPTSRGGAS 220
Length:220
Mass (Da):24,824
Last modified:May 5, 2009 - v1
Checksum:i46E64AD1B165FD7C
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei220 – 2201Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ716814 mRNA. Translation: ACN89825.1.
UniGeneiHs.208124.
Hs.744830.

Genome annotation databases

UCSCiuc011eex.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ716814 mRNA. Translation: ACN89825.1 .
UniGenei Hs.208124.
Hs.744830.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc011eex.2. human.

Miscellaneous databases

ChiTaRSi ESR1. human.
NextBioi 35482431.

Family and domain databases

Gene3Di 1.10.565.10. 3 hits.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
SMARTi SM00430. HOLI. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimer's disease brain."
    Ishunina T.A., Swaab D.F.
    Neurobiol. Aging 33:286-296(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Substantia nigraImported.

Entry informationi

Entry nameiC0LLI8_HUMAN
AccessioniPrimary (citable) accession number: C0LLI8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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