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Protein
Submitted name:

Estrogen receptor alpha delta 6,7 isoform

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor alpha delta 6,7 isoformImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000206249.

Family & Domainsi

Family and domain databases

Gene3Di1.10.565.10. 3 hits.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.

Sequencei

Sequence statusi: Fragment.

C0LLI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RKSCQACRLR KCYEVGMMKG GIRKDRRGGR MLKHKRQRDD GEGRGEVGSA
60 70 80 90 100
GDMRAANLWP SPLMIKRSKK NSLALSLTAD QMVSALLDAE PPILYSEYDP
110 120 130 140 150
TRPFSEASMM GLLTNLADRE LVHMINWAKR VPGFVDLTLH DQVHLLECAW
160 170 180 190 200
LEILMIGLVW RSMEHPGKLL FAPNLLLDSN KGMEHLYSMK CKNVVPLYDL
210 220
LLEMLDAHRL HAPTSRGGAS
Length:220
Mass (Da):24,824
Last modified:May 5, 2009 - v1
Checksum:i46E64AD1B165FD7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei220 – 2201Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ716814 mRNA. Translation: ACN89825.1.
UniGeneiHs.208124.
Hs.744830.

Genome annotation databases

UCSCiuc011eex.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ716814 mRNA. Translation: ACN89825.1.
UniGeneiHs.208124.
Hs.744830.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000206249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc011eex.2. human.

Miscellaneous databases

ChiTaRSiESR1. human.
NextBioi35482431.

Family and domain databases

Gene3Di1.10.565.10. 3 hits.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Decreased alternative splicing of estrogen receptor-alpha mRNA in the Alzheimer's disease brain."
    Ishunina T.A., Swaab D.F.
    Neurobiol. Aging 33:286-296(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Substantia nigraImported.

Entry informationi

Entry nameiC0LLI8_HUMAN
AccessioniPrimary (citable) accession number: C0LLI8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.