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C0LGU0

- RLK_ARATH

UniProt

C0LGU0 - RLK_ARATH

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Protein

Probable LRR receptor-like serine/threonine-protein kinase RLK

Gene

RLK

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei385 – 3851ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi363 – 3719ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G35390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase RLK (EC:2.7.11.1)
Gene namesi
Name:RLK
Ordered Locus Names:At5g35390
ORF Names:T26D22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G35390.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Preferentially localized to the apical region of the pollen tube plasma membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 256225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 662385CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 662631Probable LRR receptor-like serine/threonine-protein kinase RLKPRO_0000387521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei437 – 4371PhosphoserineBy similarity
Modified residuei457 – 4571PhosphothreonineBy similarity
Modified residuei527 – 5271PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGU0.
PRIDEiC0LGU0.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G35390.1-P.

Structurei

3D structure databases

ProteinModelPortaliC0LGU0.
SMRiC0LGU0. Positions 46-242, 322-638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 9820LRR 1Add
BLAST
Repeati99 – 12123LRR 2Add
BLAST
Repeati122 – 14423LRR 3Add
BLAST
Repeati147 – 16923LRR 4Add
BLAST
Repeati171 – 19121LRR 5Add
BLAST
Repeati192 – 21423LRR 6Add
BLAST
Domaini357 – 639283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619.
HOGENOMiHOG000116554.
InParanoidiC0LGU0.
OMAiRTLSFMD.
PhylomeDBiC0LGU0.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPMQARTLS VYNVMVPLVC LLLFFSTPTH GLSDSEAILK FKESLVVGQE
60 70 80 90 100
NALASWNAKS PPCTWSGVLC NGGSVWRLQM ENLELSGSID IEALSGLTSL
110 120 130 140 150
RTLSFMNNKF EGPFPDFKKL AALKSLYLSN NQFGGDIPGD AFEGMGWLKK
160 170 180 190 200
VHLAQNKFTG QIPSSVAKLP KLLELRLDGN QFTGEIPEFE HQLHLLNLSN
210 220 230 240 250
NALTGPIPES LSMTDPKVFE GNKGLYGKPL ETECDSPYIE HPPQSEARPK
260 270 280 290 300
SSSRGPLVIT AIVAALTILI ILGVIFLLNR SYKNKKPRLA VETGPSSLQK
310 320 330 340 350
KTGIREADQS RRDRKKADHR KGSGTTKRMG AAAGVENTKL SFLREDREKF
360 370 380 390 400
DLQDLLKASA EILGSGCFGA SYKAVLSSGQ MMVVKRFKQM NNAGRDEFQE
410 420 430 440 450
HMKRLGRLMH HNLLSIVAYY YRKEEKLLVC DFAERGSLAI NLHSNQSLGK
460 470 480 490 500
PSLDWPTRLK IVKGVAKGLF YLHQDLPSLM APHGHLKSSN VLLTKTFEPL
510 520 530 540 550
LTDYGLIPLI NQEKAQMHMA AYRSPEYLQH RRITKKTDVW GLGILILEIL
560 570 580 590 600
TGKFPANFSQ SSEEDLASWV NSGFHGVWAP SLFDKGMGKT SHCEGQILKL
610 620 630 640 650
LTIGLNCCEP DVEKRLDIGQ AVEKIEELKE REGDDDDFYS TYVSETDGRS
660
SKGESCESIS FA
Length:662
Mass (Da):73,483
Last modified:May 5, 2009 - v1
Checksum:i1F441F0B84D9CE8C
GO

Sequence cautioni

The sequence AAC13607.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB11489.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058826 Genomic DNA. Translation: AAC13607.1. Sequence problems.
AB025636 Genomic DNA. Translation: BAB11489.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED93962.1.
FJ708784 mRNA. Translation: ACN59375.1.
PIRiT01183.
RefSeqiNP_198389.2. NM_122930.2.
UniGeneiAt.55132.

Genome annotation databases

EnsemblPlantsiAT5G35390.1; AT5G35390.1; AT5G35390.
GeneIDi833500.
KEGGiath:AT5G35390.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058826 Genomic DNA. Translation: AAC13607.1 . Sequence problems.
AB025636 Genomic DNA. Translation: BAB11489.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED93962.1 .
FJ708784 mRNA. Translation: ACN59375.1 .
PIRi T01183.
RefSeqi NP_198389.2. NM_122930.2.
UniGenei At.55132.

3D structure databases

ProteinModelPortali C0LGU0.
SMRi C0LGU0. Positions 46-242, 322-638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G35390.1-P.

Proteomic databases

PaxDbi C0LGU0.
PRIDEi C0LGU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G35390.1 ; AT5G35390.1 ; AT5G35390 .
GeneIDi 833500.
KEGGi ath:AT5G35390.

Organism-specific databases

GeneFarmi 550. 47.
TAIRi AT5G35390.

Phylogenomic databases

eggNOGi KOG0619.
HOGENOMi HOG000116554.
InParanoidi C0LGU0.
OMAi RTLSFMD.
PhylomeDBi C0LGU0.

Enzyme and pathway databases

BioCyci ARA:AT5G35390-MONOMER.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. XI."
    Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H., Tabata S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Rho-GTPase-dependent filamentous actin dynamics coordinate vesicle targeting and exocytosis during tip growth."
    Lee Y.J., Szumlanski A., Nielsen E., Yang Z.
    J. Cell Biol. 181:1155-1168(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRLK_ARATH
AccessioniPrimary (citable) accession number: C0LGU0
Secondary accession number(s): O65240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3