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Protein

Probable LRR receptor-like serine/threonine-protein kinase At5g10290

Gene

At5g10290

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei318 – 3181ATPPROSITE-ProRule annotation
Active sitei417 – 4171Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi296 – 3049ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G10290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At5g10290 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At5g10290
ORF Names:F18D22.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G10290.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 225194ExtracellularSequence AnalysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence AnalysisAdd
BLAST
Topological domaini247 – 613367CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 613582Probable LRR receptor-like serine/threonine-protein kinase At5g10290PRO_0000387560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Modified residuei287 – 2871PhosphothreonineBy similarity
Modified residuei313 – 3131PhosphothreonineBy similarity
Modified residuei371 – 3711PhosphoserineBy similarity
Modified residuei390 – 3901PhosphothreonineBy similarity
Modified residuei450 – 4501PhosphothreonineBy similarity
Modified residuei451 – 4511PhosphothreonineBy similarity
Modified residuei456 – 4561PhosphothreonineBy similarity
Modified residuei464 – 4641PhosphotyrosineBy similarity
Modified residuei466 – 4661PhosphoserineBy similarity
Modified residuei467 – 4671PhosphothreonineBy similarity
Modified residuei471 – 4711PhosphoserineBy similarity
Modified residuei547 – 5471PhosphothreonineBy similarity
Modified residuei610 – 6101PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGT1.
PRIDEiC0LGT1.

Interactioni

Protein-protein interaction databases

BioGridi16171. 1 interaction.
STRINGi3702.AT5G10290.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGT1.
SMRiC0LGT1. Positions 28-219, 238-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati95 – 11723LRR 1Add
BLAST
Repeati119 – 14123LRR 2Add
BLAST
Repeati143 – 16624LRR 3Add
BLAST
Repeati167 – 18923LRR 4Add
BLAST
Domaini290 – 569280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116554.
InParanoidiC0LGT1.
OMAiDNFSERN.
PhylomeDBiC0LGT1.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMFSLQKMA MAFTLLFFAC LCSFVSPDAQ GDALFALRIS LRALPNQLSD
60 70 80 90 100
WNQNQVNPCT WSQVICDDKN FVTSLTLSDM NFSGTLSSRV GILENLKTLT
110 120 130 140 150
LKGNGITGEI PEDFGNLTSL TSLDLEDNQL TGRIPSTIGN LKKLQFLTLS
160 170 180 190 200
RNKLNGTIPE SLTGLPNLLN LLLDSNSLSG QIPQSLFEIP KYNFTSNNLN
210 220 230 240 250
CGGRQPHPCV SAVAHSGDSS KPKTGIIAGV VAGVTVVLFG ILLFLFCKDR
260 270 280 290 300
HKGYRRDVFV DVAGEVDRRI AFGQLKRFAW RELQLATDNF SEKNVLGQGG
310 320 330 340 350
FGKVYKGVLP DNTKVAVKRL TDFESPGGDA AFQREVEMIS VAVHRNLLRL
360 370 380 390 400
IGFCTTQTER LLVYPFMQNL SLAHRLREIK AGDPVLDWET RKRIALGAAR
410 420 430 440 450
GFEYLHEHCN PKIIHRDVKA ANVLLDEDFE AVVGDFGLAK LVDVRRTNVT
460 470 480 490 500
TQVRGTMGHI APEYLSTGKS SERTDVFGYG IMLLELVTGQ RAIDFSRLEE
510 520 530 540 550
EDDVLLLDHV KKLEREKRLG AIVDKNLDGE YIKEEVEMMI QVALLCTQGS
560 570 580 590 600
PEDRPVMSEV VRMLEGEGLA ERWEEWQNVE VTRRHEFERL QRRFDWGEDS
610
MHNQDAIELS GGR
Length:613
Mass (Da):68,659
Last modified:May 5, 2009 - v1
Checksum:iB71BE8151BA387B7
GO

Sequence cautioni

The sequence CAB96685.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371E → G in AAM13028 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360334 Genomic DNA. Translation: CAB96685.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91517.1.
AY093029 mRNA. Translation: AAM13028.1.
FJ708775 mRNA. Translation: ACN59366.1.
PIRiT50817.
RefSeqiNP_196591.2. NM_121067.3.
UniGeneiAt.6000.

Genome annotation databases

EnsemblPlantsiAT5G10290.1; AT5G10290.1; AT5G10290.
GeneIDi830893.
KEGGiath:AT5G10290.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360334 Genomic DNA. Translation: CAB96685.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91517.1.
AY093029 mRNA. Translation: AAM13028.1.
FJ708775 mRNA. Translation: ACN59366.1.
PIRiT50817.
RefSeqiNP_196591.2. NM_121067.3.
UniGeneiAt.6000.

3D structure databases

ProteinModelPortaliC0LGT1.
SMRiC0LGT1. Positions 28-219, 238-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16171. 1 interaction.
STRINGi3702.AT5G10290.1.

Proteomic databases

PaxDbiC0LGT1.
PRIDEiC0LGT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G10290.1; AT5G10290.1; AT5G10290.
GeneIDi830893.
KEGGiath:AT5G10290.

Organism-specific databases

GeneFarmi507. 46.
TAIRiAT5G10290.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116554.
InParanoidiC0LGT1.
OMAiDNFSERN.
PhylomeDBiC0LGT1.

Enzyme and pathway databases

BioCyciARA:AT5G10290-MONOMER.

Miscellaneous databases

PROiC0LGT1.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiY5129_ARATH
AccessioniPrimary (citable) accession number: C0LGT1
Secondary accession number(s): Q8RWK7, Q9LFT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.