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C0LGT1

- Y5129_ARATH

UniProt

C0LGT1 - Y5129_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At5g10290

Gene

At5g10290

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei318 – 3181ATPPROSITE-ProRule annotation
    Active sitei417 – 4171Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi296 – 3049ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G10290-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At5g10290 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At5g10290
    ORF Names:F18D22.60
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G10290.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 613582Probable LRR receptor-like serine/threonine-protein kinase At5g10290PRO_0000387560Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Modified residuei287 – 2871PhosphothreonineBy similarity
    Modified residuei313 – 3131PhosphothreonineBy similarity
    Modified residuei371 – 3711PhosphoserineBy similarity
    Modified residuei390 – 3901PhosphothreonineBy similarity
    Modified residuei450 – 4501PhosphothreonineBy similarity
    Modified residuei451 – 4511PhosphothreonineBy similarity
    Modified residuei456 – 4561PhosphothreonineBy similarity
    Modified residuei464 – 4641PhosphotyrosineBy similarity
    Modified residuei466 – 4661PhosphoserineBy similarity
    Modified residuei467 – 4671PhosphothreonineBy similarity
    Modified residuei471 – 4711PhosphoserineBy similarity
    Modified residuei547 – 5471PhosphothreonineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiC0LGT1.
    PRIDEiC0LGT1.

    Interactioni

    Protein-protein interaction databases

    BioGridi16171. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGT1.
    SMRiC0LGT1. Positions 28-183, 238-580.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 225194ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini247 – 613367CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati95 – 11723LRR 1Add
    BLAST
    Repeati119 – 14123LRR 2Add
    BLAST
    Repeati143 – 16624LRR 3Add
    BLAST
    Repeati167 – 18923LRR 4Add
    BLAST
    Domaini290 – 569280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 4 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116554.
    InParanoidiQ8RWK7.
    OMAiREFKPGE.
    PhylomeDBiC0LGT1.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C0LGT1-1 [UniParc]FASTAAdd to Basket

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    MRMFSLQKMA MAFTLLFFAC LCSFVSPDAQ GDALFALRIS LRALPNQLSD    50
    WNQNQVNPCT WSQVICDDKN FVTSLTLSDM NFSGTLSSRV GILENLKTLT 100
    LKGNGITGEI PEDFGNLTSL TSLDLEDNQL TGRIPSTIGN LKKLQFLTLS 150
    RNKLNGTIPE SLTGLPNLLN LLLDSNSLSG QIPQSLFEIP KYNFTSNNLN 200
    CGGRQPHPCV SAVAHSGDSS KPKTGIIAGV VAGVTVVLFG ILLFLFCKDR 250
    HKGYRRDVFV DVAGEVDRRI AFGQLKRFAW RELQLATDNF SEKNVLGQGG 300
    FGKVYKGVLP DNTKVAVKRL TDFESPGGDA AFQREVEMIS VAVHRNLLRL 350
    IGFCTTQTER LLVYPFMQNL SLAHRLREIK AGDPVLDWET RKRIALGAAR 400
    GFEYLHEHCN PKIIHRDVKA ANVLLDEDFE AVVGDFGLAK LVDVRRTNVT 450
    TQVRGTMGHI APEYLSTGKS SERTDVFGYG IMLLELVTGQ RAIDFSRLEE 500
    EDDVLLLDHV KKLEREKRLG AIVDKNLDGE YIKEEVEMMI QVALLCTQGS 550
    PEDRPVMSEV VRMLEGEGLA ERWEEWQNVE VTRRHEFERL QRRFDWGEDS 600
    MHNQDAIELS GGR 613
    Length:613
    Mass (Da):68,659
    Last modified:May 5, 2009 - v1
    Checksum:iB71BE8151BA387B7
    GO

    Sequence cautioni

    The sequence CAB96685.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti537 – 5371E → G in AAM13028. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL360334 Genomic DNA. Translation: CAB96685.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED91517.1.
    AY093029 mRNA. Translation: AAM13028.1.
    FJ708775 mRNA. Translation: ACN59366.1.
    PIRiT50817.
    RefSeqiNP_196591.2. NM_121067.3.
    UniGeneiAt.6000.

    Genome annotation databases

    EnsemblPlantsiAT5G10290.1; AT5G10290.1; AT5G10290.
    GeneIDi830893.
    KEGGiath:AT5G10290.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL360334 Genomic DNA. Translation: CAB96685.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED91517.1 .
    AY093029 mRNA. Translation: AAM13028.1 .
    FJ708775 mRNA. Translation: ACN59366.1 .
    PIRi T50817.
    RefSeqi NP_196591.2. NM_121067.3.
    UniGenei At.6000.

    3D structure databases

    ProteinModelPortali C0LGT1.
    SMRi C0LGT1. Positions 28-183, 238-580.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 16171. 1 interaction.

    Proteomic databases

    PaxDbi C0LGT1.
    PRIDEi C0LGT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G10290.1 ; AT5G10290.1 ; AT5G10290 .
    GeneIDi 830893.
    KEGGi ath:AT5G10290.

    Organism-specific databases

    GeneFarmi 507. 46.
    TAIRi AT5G10290.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116554.
    InParanoidi Q8RWK7.
    OMAi REFKPGE.
    PhylomeDBi C0LGT1.

    Enzyme and pathway databases

    BioCyci ARA:AT5G10290-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF12799. LRR_4. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiY5129_ARATH
    AccessioniPrimary (citable) accession number: C0LGT1
    Secondary accession number(s): Q8RWK7, Q9LFT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3