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Protein

Probable LRR receptor-like serine/threonine-protein kinase At5g10290

Gene

At5g10290

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei318ATPPROSITE-ProRule annotation1
Active sitei417Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi296 – 304ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At5g10290 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At5g10290
ORF Names:F18D22.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G10290.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 225ExtracellularSequence analysisAdd BLAST194
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 613CytoplasmicSequence analysisAdd BLAST367

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000038756032 – 613Probable LRR receptor-like serine/threonine-protein kinase At5g10290Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Modified residuei287PhosphothreonineBy similarity1
Modified residuei313PhosphothreonineBy similarity1
Modified residuei371PhosphoserineBy similarity1
Modified residuei390PhosphothreonineBy similarity1
Modified residuei450PhosphothreonineBy similarity1
Modified residuei451PhosphothreonineBy similarity1
Modified residuei456PhosphothreonineBy similarity1
Modified residuei464PhosphotyrosineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei467PhosphothreonineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei547PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGT1.

PTM databases

iPTMnetiC0LGT1.
SwissPalmiC0LGT1.

Expressioni

Gene expression databases

GenevisibleiC0LGT1. AT.

Interactioni

Protein-protein interaction databases

BioGridi16171. 44 interactors.
STRINGi3702.AT5G10290.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGT1.
SMRiC0LGT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati95 – 117LRR 1Add BLAST23
Repeati119 – 141LRR 2Add BLAST23
Repeati143 – 166LRR 3Add BLAST24
Repeati167 – 189LRR 4Add BLAST23
Domaini290 – 569Protein kinasePROSITE-ProRule annotationAdd BLAST280

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGBP. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116554.
InParanoidiC0LGT1.
OMAiEWQNVEV.
OrthoDBiEOG093605IU.
PhylomeDBiC0LGT1.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMFSLQKMA MAFTLLFFAC LCSFVSPDAQ GDALFALRIS LRALPNQLSD
60 70 80 90 100
WNQNQVNPCT WSQVICDDKN FVTSLTLSDM NFSGTLSSRV GILENLKTLT
110 120 130 140 150
LKGNGITGEI PEDFGNLTSL TSLDLEDNQL TGRIPSTIGN LKKLQFLTLS
160 170 180 190 200
RNKLNGTIPE SLTGLPNLLN LLLDSNSLSG QIPQSLFEIP KYNFTSNNLN
210 220 230 240 250
CGGRQPHPCV SAVAHSGDSS KPKTGIIAGV VAGVTVVLFG ILLFLFCKDR
260 270 280 290 300
HKGYRRDVFV DVAGEVDRRI AFGQLKRFAW RELQLATDNF SEKNVLGQGG
310 320 330 340 350
FGKVYKGVLP DNTKVAVKRL TDFESPGGDA AFQREVEMIS VAVHRNLLRL
360 370 380 390 400
IGFCTTQTER LLVYPFMQNL SLAHRLREIK AGDPVLDWET RKRIALGAAR
410 420 430 440 450
GFEYLHEHCN PKIIHRDVKA ANVLLDEDFE AVVGDFGLAK LVDVRRTNVT
460 470 480 490 500
TQVRGTMGHI APEYLSTGKS SERTDVFGYG IMLLELVTGQ RAIDFSRLEE
510 520 530 540 550
EDDVLLLDHV KKLEREKRLG AIVDKNLDGE YIKEEVEMMI QVALLCTQGS
560 570 580 590 600
PEDRPVMSEV VRMLEGEGLA ERWEEWQNVE VTRRHEFERL QRRFDWGEDS
610
MHNQDAIELS GGR
Length:613
Mass (Da):68,659
Last modified:May 5, 2009 - v1
Checksum:iB71BE8151BA387B7
GO

Sequence cautioni

The sequence CAB96685 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537E → G in AAM13028 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360334 Genomic DNA. Translation: CAB96685.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91517.1.
AY093029 mRNA. Translation: AAM13028.1.
FJ708775 mRNA. Translation: ACN59366.1.
PIRiT50817.
RefSeqiNP_196591.2. NM_121067.4.
UniGeneiAt.6000.

Genome annotation databases

EnsemblPlantsiAT5G10290.1; AT5G10290.1; AT5G10290.
GeneIDi830893.
GrameneiAT5G10290.1; AT5G10290.1; AT5G10290.
KEGGiath:AT5G10290.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360334 Genomic DNA. Translation: CAB96685.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91517.1.
AY093029 mRNA. Translation: AAM13028.1.
FJ708775 mRNA. Translation: ACN59366.1.
PIRiT50817.
RefSeqiNP_196591.2. NM_121067.4.
UniGeneiAt.6000.

3D structure databases

ProteinModelPortaliC0LGT1.
SMRiC0LGT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16171. 44 interactors.
STRINGi3702.AT5G10290.1.

PTM databases

iPTMnetiC0LGT1.
SwissPalmiC0LGT1.

Proteomic databases

PaxDbiC0LGT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G10290.1; AT5G10290.1; AT5G10290.
GeneIDi830893.
GrameneiAT5G10290.1; AT5G10290.1; AT5G10290.
KEGGiath:AT5G10290.

Organism-specific databases

TAIRiAT5G10290.

Phylogenomic databases

eggNOGiENOG410IGBP. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116554.
InParanoidiC0LGT1.
OMAiEWQNVEV.
OrthoDBiEOG093605IU.
PhylomeDBiC0LGT1.

Miscellaneous databases

PROiC0LGT1.

Gene expression databases

GenevisibleiC0LGT1. AT.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY5129_ARATH
AccessioniPrimary (citable) accession number: C0LGT1
Secondary accession number(s): Q8RWK7, Q9LFT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.