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Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g37250

Gene

At4g37250

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At4g37250 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At4g37250
ORF Names:AP22.22, C7A10.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G37250.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 328ExtracellularSequence analysisAdd BLAST307
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 768CytoplasmicSequence analysisAdd BLAST419

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038755822 – 768Probable LRR receptor-like serine/threonine-protein kinase At4g37250Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Modified residuei451PhosphoserineBy similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei553PhosphothreonineBy similarity1
Modified residuei662PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGS3.

PTM databases

iPTMnetiC0LGS3.

Expressioni

Gene expression databases

GenevisibleiC0LGS3. AT.

Interactioni

Protein-protein interaction databases

BioGridi15160. 17 interactors.
STRINGi3702.AT4G37250.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 90LRR 1Add BLAST24
Repeati91 – 112LRR 2Add BLAST22
Repeati115 – 137LRR 3Add BLAST23
Repeati139 – 162LRR 4Add BLAST24
Repeati163 – 183LRR 5Add BLAST21
Repeati184 – 206LRR 6Add BLAST23
Repeati207 – 229LRR 7Add BLAST23
Repeati232 – 254LRR 8Add BLAST23
Domaini449 – 756Protein kinasePROSITE-ProRule annotationAdd BLAST308

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEII. Eukaryota.
ENOG410YAQD. LUCA.
HOGENOMiHOG000116554.
InParanoidiC0LGS3.
OMAiCAPESFR.
OrthoDBiEOG093603O3.
PhylomeDBiC0LGS3.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMELISVIF FFFCSVLSSS ALNSDGLVLM KFKSSVLVDP LSLLQTWNYK
60 70 80 90 100
HESPCSWRGI SCNNDSKVLT LSLPNSQLLG SIPSDLGSLL TLQSLDLSNN
110 120 130 140 150
SFNGPLPVSF FNARELRFLD LSSNMISGEI PSAIGDLHNL LTLNLSDNAL
160 170 180 190 200
AGKLPTNLAS LRNLTVVSLE NNYFSGEIPG GWRVVEFLDL SSNLINGSLP
210 220 230 240 250
PDFGGYSLQY LNVSFNQISG EIPPEIGVNF PRNVTVDLSF NNLTGPIPDS
260 270 280 290 300
PVFLNQESNF FSGNPGLCGE PTRNPCLIPS SPSIVSEADV PTSTPAIAAI
310 320 330 340 350
PNTIGSNPVT DPNSQQTDPN PRTGLRPGVI IGIVVGDIAG IGILAVIFLY
360 370 380 390 400
IYRCKKNKIV DNNNNDKQRT ETDTITLSTF SSSSSSPEES RRFRKWSCLR
410 420 430 440 450
KDPETTPSEE EDEDDEDEES GYNANQRSGD NKLVTVDGEK EMEIETLLKA
460 470 480 490 500
SAYILGATGS SIMYKAVLED GRVFAVRRLG ENGLSQRRFK DFEPHIRAIG
510 520 530 540 550
KLVHPNLVRL CGFYWGTDEK LVIYDFVPNG SLVNPRYRKG GGSSSPYHLP
560 570 580 590 600
WETRLKIAKG IARGLAYLHE KKHVHGNLKP SNILLGHDME PKIGDFGLER
610 620 630 640 650
LLTGETSYIR AGGSSRIFSS KRYTTSSREF SSIGPTPSPS PSSVGAMSPY
660 670 680 690 700
CAPESFRSLK PSPKWDVYGF GVILLELLTG KIVSVEEIVL GNGLTVEDGH
710 720 730 740 750
RAVRMADVAI RGELDGKQEF LLDCFKLGYS CASPVPQKRP TMKESLAVLE
760
RFHPNSSVIK SSSFHYGH
Length:768
Mass (Da):84,063
Last modified:May 5, 2009 - v1
Checksum:i03057CD65F6A364B
GO

Sequence cautioni

The sequence CAB16774 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB80391 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361D → Y in AAN72248 (PubMed:14593172).Curated1
Sequence conflicti361D → Y in AAL57701 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99707 Genomic DNA. Translation: CAB16774.1. Different initiation.
AL161591 Genomic DNA. Translation: CAB80391.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86773.1.
AY065068 mRNA. Translation: AAL57701.1.
BT002237 mRNA. Translation: AAN72248.1.
FJ708765 mRNA. Translation: ACN59358.1.
AK317633 mRNA. Translation: BAH20295.1.
PIRiB85440.
RefSeqiNP_195442.2. NM_119888.3.
UniGeneiAt.27846.

Genome annotation databases

EnsemblPlantsiAT4G37250.1; AT4G37250.1; AT4G37250.
GeneIDi829879.
GrameneiAT4G37250.1; AT4G37250.1; AT4G37250.
KEGGiath:AT4G37250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99707 Genomic DNA. Translation: CAB16774.1. Different initiation.
AL161591 Genomic DNA. Translation: CAB80391.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86773.1.
AY065068 mRNA. Translation: AAL57701.1.
BT002237 mRNA. Translation: AAN72248.1.
FJ708765 mRNA. Translation: ACN59358.1.
AK317633 mRNA. Translation: BAH20295.1.
PIRiB85440.
RefSeqiNP_195442.2. NM_119888.3.
UniGeneiAt.27846.

3D structure databases

ProteinModelPortaliC0LGS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15160. 17 interactors.
STRINGi3702.AT4G37250.1.

PTM databases

iPTMnetiC0LGS3.

Proteomic databases

PaxDbiC0LGS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G37250.1; AT4G37250.1; AT4G37250.
GeneIDi829879.
GrameneiAT4G37250.1; AT4G37250.1; AT4G37250.
KEGGiath:AT4G37250.

Organism-specific databases

TAIRiAT4G37250.

Phylogenomic databases

eggNOGiENOG410IEII. Eukaryota.
ENOG410YAQD. LUCA.
HOGENOMiHOG000116554.
InParanoidiC0LGS3.
OMAiCAPESFR.
OrthoDBiEOG093603O3.
PhylomeDBiC0LGS3.

Miscellaneous databases

PROiC0LGS3.

Gene expression databases

GenevisibleiC0LGS3. AT.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY4372_ARATH
AccessioniPrimary (citable) accession number: C0LGS3
Secondary accession number(s): B9DHS8, O23161, Q8VZC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.