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C0LGS2 (Y4361_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable LRR receptor-like serine/threonine-protein kinase At4g36180
EC=2.7.11.1
Gene names
Ordered Locus Names:At4g36180
ORF Names:F23E13.70
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1136 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 26 LRR (leucine-rich) repeats.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAA18124.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB81527.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 11361114Probable LRR receptor-like serine/threonine-protein kinase At4g36180
PRO_0000387557

Regions

Topological domain23 – 751729Extracellular Potential
Transmembrane752 – 77221Helical; Potential
Topological domain773 – 1136364Cytoplasmic Potential
Repeat93 – 11523LRR 1
Repeat117 – 13923LRR 2
Repeat141 – 16222LRR 3
Repeat163 – 18624LRR 4
Repeat187 – 21024LRR 5
Repeat211 – 23323LRR 6
Repeat235 – 25622LRR 7
Repeat259 – 28022LRR 8
Repeat283 – 30422LRR 9
Repeat309 – 33022LRR 10
Repeat333 – 35523LRR 11
Repeat357 – 37923LRR 12
Repeat381 – 40323LRR 13
Repeat405 – 42622LRR 14
Repeat429 – 45224LRR 15
Repeat453 – 47927LRR 16
Repeat480 – 50021LRR 17
Repeat501 – 52424LRR 18
Repeat525 – 54622LRR 19
Repeat549 – 57123LRR 30
Repeat573 – 59523LRR 21
Repeat597 – 62024LRR 22
Repeat621 – 64323LRR 23
Repeat645 – 66622LRR 24
Repeat669 – 69123LRR 25
Repeat694 – 71623LRR 26
Domain841 – 1123283Protein kinase

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential
Glycosylation4821N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation5351N-linked (GlcNAc...) Potential
Glycosylation5541N-linked (GlcNAc...) Potential
Glycosylation5941N-linked (GlcNAc...) Potential
Glycosylation6311N-linked (GlcNAc...) Potential
Glycosylation6691N-linked (GlcNAc...) Potential
Glycosylation6791N-linked (GlcNAc...) Potential
Glycosylation6991N-linked (GlcNAc...) Potential
Glycosylation7191N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C0LGS2 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 7AA32A277F6F2820

FASTA1,136123,664
        10         20         30         40         50         60 
MAMDISLFFI FLVIYAPLVS YADESQAEID ALTAFKLNLH DPLGALTSWD PSTPAAPCDW 

        70         80         90        100        110        120 
RGVGCTNHRV TEIRLPRLQL SGRISDRISG LRMLRKLSLR SNSFNGTIPT SLAYCTRLLS 

       130        140        150        160        170        180 
VFLQYNSLSG KLPPAMRNLT SLEVFNVAGN RLSGEIPVGL PSSLQFLDIS SNTFSGQIPS 

       190        200        210        220        230        240 
GLANLTQLQL LNLSYNQLTG EIPASLGNLQ SLQYLWLDFN LLQGTLPSAI SNCSSLVHLS 

       250        260        270        280        290        300 
ASENEIGGVI PAAYGALPKL EVLSLSNNNF SGTVPFSLFC NTSLTIVQLG FNAFSDIVRP 

       310        320        330        340        350        360 
ETTANCRTGL QVLDLQENRI SGRFPLWLTN ILSLKNLDVS GNLFSGEIPP DIGNLKRLEE 

       370        380        390        400        410        420 
LKLANNSLTG EIPVEIKQCG SLDVLDFEGN SLKGQIPEFL GYMKALKVLS LGRNSFSGYV 

       430        440        450        460        470        480 
PSSMVNLQQL ERLNLGENNL NGSFPVELMA LTSLSELDLS GNRFSGAVPV SISNLSNLSF 

       490        500        510        520        530        540 
LNLSGNGFSG EIPASVGNLF KLTALDLSKQ NMSGEVPVEL SGLPNVQVIA LQGNNFSGVV 

       550        560        570        580        590        600 
PEGFSSLVSL RYVNLSSNSF SGEIPQTFGF LRLLVSLSLS DNHISGSIPP EIGNCSALEV 

       610        620        630        640        650        660 
LELRSNRLMG HIPADLSRLP RLKVLDLGQN NLSGEIPPEI SQSSSLNSLS LDHNHLSGVI 

       670        680        690        700        710        720 
PGSFSGLSNL TKMDLSVNNL TGEIPASLAL ISSNLVYFNV SSNNLKGEIP ASLGSRINNT 

       730        740        750        760        770        780 
SEFSGNTELC GKPLNRRCES STAEGKKKKR KMILMIVMAA IGAFLLSLFC CFYVYTLLKW 

       790        800        810        820        830        840 
RKKLKQQSTT GEKKRSPGRT SAGSRVRSST SRSSTENGEP KLVMFNNKIT LAETIEATRQ 

       850        860        870        880        890        900 
FDEENVLSRT RYGLLFKANY NDGMVLSIRR LPNGSLLNEN LFKKEAEVLG KVKHRNITVL 

       910        920        930        940        950        960 
RGYYAGPPDL RLLVYDYMPN GNLSTLLQEA SHQDGHVLNW PMRHLIALGI ARGLGFLHQS 

       970        980        990       1000       1010       1020 
NMVHGDIKPQ NVLFDADFEA HISDFGLDRL TIRSPSRSAV TANTIGTLGY VSPEATLSGE 

      1030       1040       1050       1060       1070       1080 
ITRESDIYSF GIVLLEILTG KRPVMFTQDE DIVKWVKKQL QRGQVTELLE PGLLELDPES 

      1090       1100       1110       1120       1130 
SEWEEFLLGI KVGLLCTATD PLDRPTMSDV VFMLEGCRVG PDVPSSADPT SQPSPA

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. expand/collapse author list , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1136.
Strain: cv. Columbia.
[5]"Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis."
Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M., Menke F.L.H.
Mol. Cell. Proteomics 6:1198-1214(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
Strain: cv. Columbia.
[6]"A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL022141 Genomic DNA. Translation: CAA18124.1. Different initiation.
AL161588 Genomic DNA. Translation: CAB81527.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86628.1.
FJ708764 mRNA. Translation: ACN59357.1.
AY080606 mRNA. Translation: AAL86290.1.
IPIIPI00531277.
PIRT04587.
RefSeqNP_195341.2. NM_119785.3.
UniGeneAt.2123.

3D structure databases

ProteinModelPortalC0LGS2.
SMRC0LGS2. Positions 28-734, 827-1116.
ModBaseSearch...

Protein-protein interaction databases

STRING3702.AT4G36180.1-P.

Proteomic databases

PaxDbC0LGS2.
PRIDEC0LGS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT4G36180.1; AT4G36180.1; AT4G36180.
GeneID829775.
KEGGath:AT4G36180.

Organism-specific databases

GeneFarm2360. 51.
TAIRAt4g36180.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000116551.
InParanoidO65510.
OMANCSSLVH.
PhylomeDBC0LGS2.
ProtClustDBCLSN2682550.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_cat_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00560. LRR_1. 3 hits.
PF12799. LRR_4. 2 hits.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY4361_ARATH
AccessionPrimary (citable) accession number: C0LGS2
Secondary accession number(s): O65510, Q8RXY8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents