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Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g36180

Gene

At4g36180

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At4g36180 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At4g36180
ORF Names:F23E13.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G36180.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 751ExtracellularSequence analysisAdd BLAST729
Transmembranei752 – 772HelicalSequence analysisAdd BLAST21
Topological domaini773 – 1136CytoplasmicSequence analysisAdd BLAST364

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000038755723 – 1136Probable LRR receptor-like serine/threonine-protein kinase At4g36180Add BLAST1114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi477N-linked (GlcNAc...)Sequence analysis1
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1
Glycosylationi511N-linked (GlcNAc...)Sequence analysis1
Glycosylationi535N-linked (GlcNAc...)Sequence analysis1
Glycosylationi554N-linked (GlcNAc...)Sequence analysis1
Glycosylationi594N-linked (GlcNAc...)Sequence analysis1
Glycosylationi631N-linked (GlcNAc...)Sequence analysis1
Glycosylationi669N-linked (GlcNAc...)Sequence analysis1
Glycosylationi679N-linked (GlcNAc...)Sequence analysis1
Glycosylationi699N-linked (GlcNAc...)Sequence analysis1
Glycosylationi719N-linked (GlcNAc...)Sequence analysis1
Modified residuei830PhosphothreonineBy similarity1
Modified residuei838PhosphothreonineBy similarity1
Modified residuei915PhosphotyrosineBy similarity1
Modified residuei1010PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGS2.

PTM databases

iPTMnetiC0LGS2.

Expressioni

Gene expression databases

GenevisibleiC0LGS2. AT.

Interactioni

Protein-protein interaction databases

BioGridi15057. 14 interactors.
STRINGi3702.AT4G36180.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGS2.
SMRiC0LGS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati93 – 115LRR 1Add BLAST23
Repeati117 – 139LRR 2Add BLAST23
Repeati141 – 162LRR 3Add BLAST22
Repeati163 – 186LRR 4Add BLAST24
Repeati187 – 210LRR 5Add BLAST24
Repeati211 – 233LRR 6Add BLAST23
Repeati235 – 256LRR 7Add BLAST22
Repeati259 – 280LRR 8Add BLAST22
Repeati283 – 304LRR 9Add BLAST22
Repeati309 – 330LRR 10Add BLAST22
Repeati333 – 355LRR 11Add BLAST23
Repeati357 – 379LRR 12Add BLAST23
Repeati381 – 403LRR 13Add BLAST23
Repeati405 – 426LRR 14Add BLAST22
Repeati429 – 452LRR 15Add BLAST24
Repeati453 – 479LRR 16Add BLAST27
Repeati480 – 500LRR 17Add BLAST21
Repeati501 – 524LRR 18Add BLAST24
Repeati525 – 546LRR 19Add BLAST22
Repeati549 – 571LRR 30Add BLAST23
Repeati573 – 595LRR 21Add BLAST23
Repeati597 – 620LRR 22Add BLAST24
Repeati621 – 643LRR 23Add BLAST23
Repeati645 – 666LRR 24Add BLAST22
Repeati669 – 691LRR 25Add BLAST23
Repeati694 – 716LRR 26Add BLAST23
Domaini841 – 1123Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 26 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG4D. Eukaryota.
COG0515. LUCA.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiC0LGS2.
OMAiVTANTIG.
OrthoDBiEOG0936014M.
PhylomeDBiC0LGS2.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 13 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDISLFFI FLVIYAPLVS YADESQAEID ALTAFKLNLH DPLGALTSWD
60 70 80 90 100
PSTPAAPCDW RGVGCTNHRV TEIRLPRLQL SGRISDRISG LRMLRKLSLR
110 120 130 140 150
SNSFNGTIPT SLAYCTRLLS VFLQYNSLSG KLPPAMRNLT SLEVFNVAGN
160 170 180 190 200
RLSGEIPVGL PSSLQFLDIS SNTFSGQIPS GLANLTQLQL LNLSYNQLTG
210 220 230 240 250
EIPASLGNLQ SLQYLWLDFN LLQGTLPSAI SNCSSLVHLS ASENEIGGVI
260 270 280 290 300
PAAYGALPKL EVLSLSNNNF SGTVPFSLFC NTSLTIVQLG FNAFSDIVRP
310 320 330 340 350
ETTANCRTGL QVLDLQENRI SGRFPLWLTN ILSLKNLDVS GNLFSGEIPP
360 370 380 390 400
DIGNLKRLEE LKLANNSLTG EIPVEIKQCG SLDVLDFEGN SLKGQIPEFL
410 420 430 440 450
GYMKALKVLS LGRNSFSGYV PSSMVNLQQL ERLNLGENNL NGSFPVELMA
460 470 480 490 500
LTSLSELDLS GNRFSGAVPV SISNLSNLSF LNLSGNGFSG EIPASVGNLF
510 520 530 540 550
KLTALDLSKQ NMSGEVPVEL SGLPNVQVIA LQGNNFSGVV PEGFSSLVSL
560 570 580 590 600
RYVNLSSNSF SGEIPQTFGF LRLLVSLSLS DNHISGSIPP EIGNCSALEV
610 620 630 640 650
LELRSNRLMG HIPADLSRLP RLKVLDLGQN NLSGEIPPEI SQSSSLNSLS
660 670 680 690 700
LDHNHLSGVI PGSFSGLSNL TKMDLSVNNL TGEIPASLAL ISSNLVYFNV
710 720 730 740 750
SSNNLKGEIP ASLGSRINNT SEFSGNTELC GKPLNRRCES STAEGKKKKR
760 770 780 790 800
KMILMIVMAA IGAFLLSLFC CFYVYTLLKW RKKLKQQSTT GEKKRSPGRT
810 820 830 840 850
SAGSRVRSST SRSSTENGEP KLVMFNNKIT LAETIEATRQ FDEENVLSRT
860 870 880 890 900
RYGLLFKANY NDGMVLSIRR LPNGSLLNEN LFKKEAEVLG KVKHRNITVL
910 920 930 940 950
RGYYAGPPDL RLLVYDYMPN GNLSTLLQEA SHQDGHVLNW PMRHLIALGI
960 970 980 990 1000
ARGLGFLHQS NMVHGDIKPQ NVLFDADFEA HISDFGLDRL TIRSPSRSAV
1010 1020 1030 1040 1050
TANTIGTLGY VSPEATLSGE ITRESDIYSF GIVLLEILTG KRPVMFTQDE
1060 1070 1080 1090 1100
DIVKWVKKQL QRGQVTELLE PGLLELDPES SEWEEFLLGI KVGLLCTATD
1110 1120 1130
PLDRPTMSDV VFMLEGCRVG PDVPSSADPT SQPSPA
Length:1,136
Mass (Da):123,664
Last modified:May 5, 2009 - v1
Checksum:i7AA32A277F6F2820
GO

Sequence cautioni

The sequence CAA18124 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB81527 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022141 Genomic DNA. Translation: CAA18124.1. Different initiation.
AL161588 Genomic DNA. Translation: CAB81527.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86628.1.
FJ708764 mRNA. Translation: ACN59357.1.
AY080606 mRNA. Translation: AAL86290.1.
PIRiT04587.
RefSeqiNP_195341.2. NM_119785.4.
UniGeneiAt.2123.

Genome annotation databases

EnsemblPlantsiAT4G36180.1; AT4G36180.1; AT4G36180.
GeneIDi829775.
GrameneiAT4G36180.1; AT4G36180.1; AT4G36180.
KEGGiath:AT4G36180.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022141 Genomic DNA. Translation: CAA18124.1. Different initiation.
AL161588 Genomic DNA. Translation: CAB81527.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86628.1.
FJ708764 mRNA. Translation: ACN59357.1.
AY080606 mRNA. Translation: AAL86290.1.
PIRiT04587.
RefSeqiNP_195341.2. NM_119785.4.
UniGeneiAt.2123.

3D structure databases

ProteinModelPortaliC0LGS2.
SMRiC0LGS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15057. 14 interactors.
STRINGi3702.AT4G36180.1.

PTM databases

iPTMnetiC0LGS2.

Proteomic databases

PaxDbiC0LGS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G36180.1; AT4G36180.1; AT4G36180.
GeneIDi829775.
GrameneiAT4G36180.1; AT4G36180.1; AT4G36180.
KEGGiath:AT4G36180.

Organism-specific databases

TAIRiAT4G36180.

Phylogenomic databases

eggNOGiENOG410IG4D. Eukaryota.
COG0515. LUCA.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiC0LGS2.
OMAiVTANTIG.
OrthoDBiEOG0936014M.
PhylomeDBiC0LGS2.

Miscellaneous databases

PROiC0LGS2.

Gene expression databases

GenevisibleiC0LGS2. AT.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 13 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY4361_ARATH
AccessioniPrimary (citable) accession number: C0LGS2
Secondary accession number(s): O65510, Q8RXY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.