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C0LGS2

- Y4361_ARATH

UniProt

C0LGS2 - Y4361_ARATH

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Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g36180

Gene

At4g36180

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G36180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At4g36180 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At4g36180
ORF Names:F23E13.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G36180.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 11361114Probable LRR receptor-like serine/threonine-protein kinase At4g36180PRO_0000387557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
Modified residuei830 – 8301PhosphothreonineBy similarity
Modified residuei838 – 8381PhosphothreonineBy similarity
Modified residuei915 – 9151PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGS2.
PRIDEiC0LGS2.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G36180.1-P.

Structurei

3D structure databases

ProteinModelPortaliC0LGS2.
SMRiC0LGS2. Positions 26-736, 828-1115.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 751729ExtracellularSequence AnalysisAdd
BLAST
Topological domaini773 – 1136364CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei752 – 77221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati93 – 11523LRR 1Add
BLAST
Repeati117 – 13923LRR 2Add
BLAST
Repeati141 – 16222LRR 3Add
BLAST
Repeati163 – 18624LRR 4Add
BLAST
Repeati187 – 21024LRR 5Add
BLAST
Repeati211 – 23323LRR 6Add
BLAST
Repeati235 – 25622LRR 7Add
BLAST
Repeati259 – 28022LRR 8Add
BLAST
Repeati283 – 30422LRR 9Add
BLAST
Repeati309 – 33022LRR 10Add
BLAST
Repeati333 – 35523LRR 11Add
BLAST
Repeati357 – 37923LRR 12Add
BLAST
Repeati381 – 40323LRR 13Add
BLAST
Repeati405 – 42622LRR 14Add
BLAST
Repeati429 – 45224LRR 15Add
BLAST
Repeati453 – 47927LRR 16Add
BLAST
Repeati480 – 50021LRR 17Add
BLAST
Repeati501 – 52424LRR 18Add
BLAST
Repeati525 – 54622LRR 19Add
BLAST
Repeati549 – 57123LRR 30Add
BLAST
Repeati573 – 59523LRR 21Add
BLAST
Repeati597 – 62024LRR 22Add
BLAST
Repeati621 – 64323LRR 23Add
BLAST
Repeati645 – 66622LRR 24Add
BLAST
Repeati669 – 69123LRR 25Add
BLAST
Repeati694 – 71623LRR 26Add
BLAST
Domaini841 – 1123283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 26 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000116551.
InParanoidiC0LGS2.
OMAiWRRRFIE.
PhylomeDBiC0LGS2.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 5 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 4 hits.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMDISLFFI FLVIYAPLVS YADESQAEID ALTAFKLNLH DPLGALTSWD
60 70 80 90 100
PSTPAAPCDW RGVGCTNHRV TEIRLPRLQL SGRISDRISG LRMLRKLSLR
110 120 130 140 150
SNSFNGTIPT SLAYCTRLLS VFLQYNSLSG KLPPAMRNLT SLEVFNVAGN
160 170 180 190 200
RLSGEIPVGL PSSLQFLDIS SNTFSGQIPS GLANLTQLQL LNLSYNQLTG
210 220 230 240 250
EIPASLGNLQ SLQYLWLDFN LLQGTLPSAI SNCSSLVHLS ASENEIGGVI
260 270 280 290 300
PAAYGALPKL EVLSLSNNNF SGTVPFSLFC NTSLTIVQLG FNAFSDIVRP
310 320 330 340 350
ETTANCRTGL QVLDLQENRI SGRFPLWLTN ILSLKNLDVS GNLFSGEIPP
360 370 380 390 400
DIGNLKRLEE LKLANNSLTG EIPVEIKQCG SLDVLDFEGN SLKGQIPEFL
410 420 430 440 450
GYMKALKVLS LGRNSFSGYV PSSMVNLQQL ERLNLGENNL NGSFPVELMA
460 470 480 490 500
LTSLSELDLS GNRFSGAVPV SISNLSNLSF LNLSGNGFSG EIPASVGNLF
510 520 530 540 550
KLTALDLSKQ NMSGEVPVEL SGLPNVQVIA LQGNNFSGVV PEGFSSLVSL
560 570 580 590 600
RYVNLSSNSF SGEIPQTFGF LRLLVSLSLS DNHISGSIPP EIGNCSALEV
610 620 630 640 650
LELRSNRLMG HIPADLSRLP RLKVLDLGQN NLSGEIPPEI SQSSSLNSLS
660 670 680 690 700
LDHNHLSGVI PGSFSGLSNL TKMDLSVNNL TGEIPASLAL ISSNLVYFNV
710 720 730 740 750
SSNNLKGEIP ASLGSRINNT SEFSGNTELC GKPLNRRCES STAEGKKKKR
760 770 780 790 800
KMILMIVMAA IGAFLLSLFC CFYVYTLLKW RKKLKQQSTT GEKKRSPGRT
810 820 830 840 850
SAGSRVRSST SRSSTENGEP KLVMFNNKIT LAETIEATRQ FDEENVLSRT
860 870 880 890 900
RYGLLFKANY NDGMVLSIRR LPNGSLLNEN LFKKEAEVLG KVKHRNITVL
910 920 930 940 950
RGYYAGPPDL RLLVYDYMPN GNLSTLLQEA SHQDGHVLNW PMRHLIALGI
960 970 980 990 1000
ARGLGFLHQS NMVHGDIKPQ NVLFDADFEA HISDFGLDRL TIRSPSRSAV
1010 1020 1030 1040 1050
TANTIGTLGY VSPEATLSGE ITRESDIYSF GIVLLEILTG KRPVMFTQDE
1060 1070 1080 1090 1100
DIVKWVKKQL QRGQVTELLE PGLLELDPES SEWEEFLLGI KVGLLCTATD
1110 1120 1130
PLDRPTMSDV VFMLEGCRVG PDVPSSADPT SQPSPA
Length:1,136
Mass (Da):123,664
Last modified:May 5, 2009 - v1
Checksum:i7AA32A277F6F2820
GO

Sequence cautioni

The sequence CAA18124.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB81527.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL022141 Genomic DNA. Translation: CAA18124.1. Different initiation.
AL161588 Genomic DNA. Translation: CAB81527.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86628.1.
FJ708764 mRNA. Translation: ACN59357.1.
AY080606 mRNA. Translation: AAL86290.1.
PIRiT04587.
RefSeqiNP_195341.2. NM_119785.3.
UniGeneiAt.2123.

Genome annotation databases

EnsemblPlantsiAT4G36180.1; AT4G36180.1; AT4G36180.
GeneIDi829775.
KEGGiath:AT4G36180.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL022141 Genomic DNA. Translation: CAA18124.1 . Different initiation.
AL161588 Genomic DNA. Translation: CAB81527.1 . Different initiation.
CP002687 Genomic DNA. Translation: AEE86628.1 .
FJ708764 mRNA. Translation: ACN59357.1 .
AY080606 mRNA. Translation: AAL86290.1 .
PIRi T04587.
RefSeqi NP_195341.2. NM_119785.3.
UniGenei At.2123.

3D structure databases

ProteinModelPortali C0LGS2.
SMRi C0LGS2. Positions 26-736, 828-1115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT4G36180.1-P.

Proteomic databases

PaxDbi C0LGS2.
PRIDEi C0LGS2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G36180.1 ; AT4G36180.1 ; AT4G36180 .
GeneIDi 829775.
KEGGi ath:AT4G36180.

Organism-specific databases

GeneFarmi 2360. 51.
TAIRi AT4G36180.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000116551.
InParanoidi C0LGS2.
OMAi WRRRFIE.
PhylomeDBi C0LGS2.

Enzyme and pathway databases

BioCyci ARA:AT4G36180-MONOMER.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00560. LRR_1. 5 hits.
PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 4 hits.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1136.
    Strain: cv. Columbia.
  5. "A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
    Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
    Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiY4361_ARATH
AccessioniPrimary (citable) accession number: C0LGS2
Secondary accession number(s): O65510, Q8RXY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3