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C0LGS2

- Y4361_ARATH

UniProt

C0LGS2 - Y4361_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g36180

Gene

At4g36180

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G36180-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At4g36180 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At4g36180
    ORF Names:F23E13.70
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G36180.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 11361114Probable LRR receptor-like serine/threonine-protein kinase At4g36180PRO_0000387557Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
    Modified residuei830 – 8301PhosphothreonineBy similarity
    Modified residuei838 – 8381PhosphothreonineBy similarity
    Modified residuei915 – 9151PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiC0LGS2.
    PRIDEiC0LGS2.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT4G36180.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGS2.
    SMRiC0LGS2. Positions 26-736, 828-1115.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 751729ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini773 – 1136364CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei752 – 77221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati93 – 11523LRR 1Add
    BLAST
    Repeati117 – 13923LRR 2Add
    BLAST
    Repeati141 – 16222LRR 3Add
    BLAST
    Repeati163 – 18624LRR 4Add
    BLAST
    Repeati187 – 21024LRR 5Add
    BLAST
    Repeati211 – 23323LRR 6Add
    BLAST
    Repeati235 – 25622LRR 7Add
    BLAST
    Repeati259 – 28022LRR 8Add
    BLAST
    Repeati283 – 30422LRR 9Add
    BLAST
    Repeati309 – 33022LRR 10Add
    BLAST
    Repeati333 – 35523LRR 11Add
    BLAST
    Repeati357 – 37923LRR 12Add
    BLAST
    Repeati381 – 40323LRR 13Add
    BLAST
    Repeati405 – 42622LRR 14Add
    BLAST
    Repeati429 – 45224LRR 15Add
    BLAST
    Repeati453 – 47927LRR 16Add
    BLAST
    Repeati480 – 50021LRR 17Add
    BLAST
    Repeati501 – 52424LRR 18Add
    BLAST
    Repeati525 – 54622LRR 19Add
    BLAST
    Repeati549 – 57123LRR 30Add
    BLAST
    Repeati573 – 59523LRR 21Add
    BLAST
    Repeati597 – 62024LRR 22Add
    BLAST
    Repeati621 – 64323LRR 23Add
    BLAST
    Repeati645 – 66622LRR 24Add
    BLAST
    Repeati669 – 69123LRR 25Add
    BLAST
    Repeati694 – 71623LRR 26Add
    BLAST
    Domaini841 – 1123283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 26 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116551.
    InParanoidiO65510.
    OMAiWRRRFIE.
    PhylomeDBiC0LGS2.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00560. LRR_1. 5 hits.
    PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 4 hits.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C0LGS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMDISLFFI FLVIYAPLVS YADESQAEID ALTAFKLNLH DPLGALTSWD     50
    PSTPAAPCDW RGVGCTNHRV TEIRLPRLQL SGRISDRISG LRMLRKLSLR 100
    SNSFNGTIPT SLAYCTRLLS VFLQYNSLSG KLPPAMRNLT SLEVFNVAGN 150
    RLSGEIPVGL PSSLQFLDIS SNTFSGQIPS GLANLTQLQL LNLSYNQLTG 200
    EIPASLGNLQ SLQYLWLDFN LLQGTLPSAI SNCSSLVHLS ASENEIGGVI 250
    PAAYGALPKL EVLSLSNNNF SGTVPFSLFC NTSLTIVQLG FNAFSDIVRP 300
    ETTANCRTGL QVLDLQENRI SGRFPLWLTN ILSLKNLDVS GNLFSGEIPP 350
    DIGNLKRLEE LKLANNSLTG EIPVEIKQCG SLDVLDFEGN SLKGQIPEFL 400
    GYMKALKVLS LGRNSFSGYV PSSMVNLQQL ERLNLGENNL NGSFPVELMA 450
    LTSLSELDLS GNRFSGAVPV SISNLSNLSF LNLSGNGFSG EIPASVGNLF 500
    KLTALDLSKQ NMSGEVPVEL SGLPNVQVIA LQGNNFSGVV PEGFSSLVSL 550
    RYVNLSSNSF SGEIPQTFGF LRLLVSLSLS DNHISGSIPP EIGNCSALEV 600
    LELRSNRLMG HIPADLSRLP RLKVLDLGQN NLSGEIPPEI SQSSSLNSLS 650
    LDHNHLSGVI PGSFSGLSNL TKMDLSVNNL TGEIPASLAL ISSNLVYFNV 700
    SSNNLKGEIP ASLGSRINNT SEFSGNTELC GKPLNRRCES STAEGKKKKR 750
    KMILMIVMAA IGAFLLSLFC CFYVYTLLKW RKKLKQQSTT GEKKRSPGRT 800
    SAGSRVRSST SRSSTENGEP KLVMFNNKIT LAETIEATRQ FDEENVLSRT 850
    RYGLLFKANY NDGMVLSIRR LPNGSLLNEN LFKKEAEVLG KVKHRNITVL 900
    RGYYAGPPDL RLLVYDYMPN GNLSTLLQEA SHQDGHVLNW PMRHLIALGI 950
    ARGLGFLHQS NMVHGDIKPQ NVLFDADFEA HISDFGLDRL TIRSPSRSAV 1000
    TANTIGTLGY VSPEATLSGE ITRESDIYSF GIVLLEILTG KRPVMFTQDE 1050
    DIVKWVKKQL QRGQVTELLE PGLLELDPES SEWEEFLLGI KVGLLCTATD 1100
    PLDRPTMSDV VFMLEGCRVG PDVPSSADPT SQPSPA 1136
    Length:1,136
    Mass (Da):123,664
    Last modified:May 5, 2009 - v1
    Checksum:i7AA32A277F6F2820
    GO

    Sequence cautioni

    The sequence CAA18124.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB81527.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022141 Genomic DNA. Translation: CAA18124.1. Different initiation.
    AL161588 Genomic DNA. Translation: CAB81527.1. Different initiation.
    CP002687 Genomic DNA. Translation: AEE86628.1.
    FJ708764 mRNA. Translation: ACN59357.1.
    AY080606 mRNA. Translation: AAL86290.1.
    PIRiT04587.
    RefSeqiNP_195341.2. NM_119785.3.
    UniGeneiAt.2123.

    Genome annotation databases

    EnsemblPlantsiAT4G36180.1; AT4G36180.1; AT4G36180.
    GeneIDi829775.
    KEGGiath:AT4G36180.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022141 Genomic DNA. Translation: CAA18124.1 . Different initiation.
    AL161588 Genomic DNA. Translation: CAB81527.1 . Different initiation.
    CP002687 Genomic DNA. Translation: AEE86628.1 .
    FJ708764 mRNA. Translation: ACN59357.1 .
    AY080606 mRNA. Translation: AAL86290.1 .
    PIRi T04587.
    RefSeqi NP_195341.2. NM_119785.3.
    UniGenei At.2123.

    3D structure databases

    ProteinModelPortali C0LGS2.
    SMRi C0LGS2. Positions 26-736, 828-1115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT4G36180.1-P.

    Proteomic databases

    PaxDbi C0LGS2.
    PRIDEi C0LGS2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G36180.1 ; AT4G36180.1 ; AT4G36180 .
    GeneIDi 829775.
    KEGGi ath:AT4G36180.

    Organism-specific databases

    GeneFarmi 2360. 51.
    TAIRi AT4G36180.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116551.
    InParanoidi O65510.
    OMAi WRRRFIE.
    PhylomeDBi C0LGS2.

    Enzyme and pathway databases

    BioCyci ARA:AT4G36180-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00560. LRR_1. 5 hits.
    PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 4 hits.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1136.
      Strain: cv. Columbia.
    5. "A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
      Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
      Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiY4361_ARATH
    AccessioniPrimary (citable) accession number: C0LGS2
    Secondary accession number(s): O65510, Q8RXY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3