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C0LGR9

- Y4312_ARATH

UniProt

C0LGR9 - Y4312_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g31250

Gene

At4g31250

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei394 – 3941ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi372 – 3809ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G31250-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At4g31250 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At4g31250
    ORF Names:F8F16.70
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G31250.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 676650Probable LRR receptor-like serine/threonine-protein kinase At4g31250PRO_0000387556Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Modified residuei368 – 3681PhosphoserineBy similarity
    Modified residuei446 – 4461PhosphoserineBy similarity
    Modified residuei543 – 5431PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiC0LGR9.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGR9.
    SMRiC0LGR9. Positions 26-256, 288-640.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 242216ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini264 – 676413CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati98 – 12225LRR 1Add
    BLAST
    Repeati123 – 14624LRR 2Add
    BLAST
    Repeati148 – 17124LRR 3Add
    BLAST
    Repeati172 – 19524LRR 4Add
    BLAST
    Repeati197 – 21822LRR 5Add
    BLAST
    Domaini366 – 640275Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116554.
    InParanoidiO49575.
    OMAiIGMCCCE.
    PhylomeDBiC0LGR9.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: C0LGR9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTRDDKFPIV YSLLLIVLLF VSPIYGDGDA DALLKFKSSL VNASSLGGWD    50
    SGEPPCSGDK GSDSKWKGVM CSNGSVFALR LENMSLSGEL DVQALGSIRG 100
    LKSISFMRNH FEGKIPRGID GLVSLAHLYL AHNQFTGEID GDLFSGMKAL 150
    LKVHLEGNRF SGEIPESLGK LPKLTELNLE DNMFTGKIPA FKQKNLVTVN 200
    VANNQLEGRI PLTLGLMNIT FFSGNKGLCG APLLPCRYTR PPFFTVFLLA 250
    LTILAVVVLI TVFLSVCILS RRQGKGQDQI QNHGVGHFHG QVYGQPEQQQ 300
    HSEKSSQDSK VYRKLANETV QRDSTATSGA ISVGGLSPDE DKRGDQRKLH 350
    FVRNDQERFT LQDMLRASAE VLGSGGFGSS YKAALSSGRA VVVKRFRFMS 400
    NIGREEFYDH MKKIGRLSHP NLLPLIAFYY RKEEKLLVTN YISNGSLANL 450
    LHANRTPGQV VLDWPIRLKI VRGVTRGLAY LYRVFPDLNL PHGHLKSSNV 500
    LLDPNFEPLL TDYALVPVVN RDQSQQFMVA YKAPEFTQQD RTSRRSDVWS 550
    LGILILEILT GKFPANYLRQ GKGADDELAA WVESVARTEW TADVFDKEMK 600
    AGKEHEAQML KLLKIGLRCC DWDIEKRIEL HEAVDRIEEV DRDAGGGQES 650
    VRSSYVTASD GDHRSSRAMT EEFSLM 676
    Length:676
    Mass (Da):75,235
    Last modified:May 5, 2009 - v1
    Checksum:i65162EF1D0782579
    GO
    Isoform 2 (identifier: C0LGR9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: Missing.
         89-98: ELDVQALGSI → MERSDVFKRL

    Note: No experimental confirmation available.

    Show »
    Length:588
    Mass (Da):66,126
    Checksum:iA2CA3D49FE525576
    GO

    Sequence cautioni

    The sequence CAA16528.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79843.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti487 – 4882DL → RI in BAF00232. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8888Missing in isoform 2. 1 PublicationVSP_038293Add
    BLAST
    Alternative sequencei89 – 9810ELDVQALGSI → MERSDVFKRL in isoform 2. 1 PublicationVSP_038294

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL021633 Genomic DNA. Translation: CAA16528.1. Sequence problems.
    AL161578 Genomic DNA. Translation: CAB79843.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85882.1.
    AK176198 mRNA. Translation: BAD43961.1.
    AK176233 mRNA. Translation: BAD43996.1.
    AK176245 mRNA. Translation: BAD44008.1.
    AK176283 mRNA. Translation: BAD44046.1.
    AK176290 mRNA. Translation: BAD44053.1.
    AK176304 mRNA. Translation: BAD44067.1.
    AK176329 mRNA. Translation: BAD44092.1.
    AK221228 mRNA. Translation: BAD93819.1.
    AK228286 mRNA. Translation: BAF00232.1.
    FJ708761 mRNA. Translation: ACN59354.1.
    PIRiT04492.
    RefSeqiNP_567870.1. NM_119274.4. [C0LGR9-1]
    UniGeneiAt.31759.

    Genome annotation databases

    EnsemblPlantsiAT4G31250.1; AT4G31250.1; AT4G31250. [C0LGR9-1]
    GeneIDi829252.
    KEGGiath:AT4G31250.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL021633 Genomic DNA. Translation: CAA16528.1 . Sequence problems.
    AL161578 Genomic DNA. Translation: CAB79843.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85882.1 .
    AK176198 mRNA. Translation: BAD43961.1 .
    AK176233 mRNA. Translation: BAD43996.1 .
    AK176245 mRNA. Translation: BAD44008.1 .
    AK176283 mRNA. Translation: BAD44046.1 .
    AK176290 mRNA. Translation: BAD44053.1 .
    AK176304 mRNA. Translation: BAD44067.1 .
    AK176329 mRNA. Translation: BAD44092.1 .
    AK221228 mRNA. Translation: BAD93819.1 .
    AK228286 mRNA. Translation: BAF00232.1 .
    FJ708761 mRNA. Translation: ACN59354.1 .
    PIRi T04492.
    RefSeqi NP_567870.1. NM_119274.4. [C0LGR9-1 ]
    UniGenei At.31759.

    3D structure databases

    ProteinModelPortali C0LGR9.
    SMRi C0LGR9. Positions 26-256, 288-640.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi C0LGR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G31250.1 ; AT4G31250.1 ; AT4G31250 . [C0LGR9-1 ]
    GeneIDi 829252.
    KEGGi ath:AT4G31250.

    Organism-specific databases

    GeneFarmi 2307. 47.
    TAIRi AT4G31250.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116554.
    InParanoidi O49575.
    OMAi IGMCCCE.
    PhylomeDBi C0LGR9.

    Enzyme and pathway databases

    BioCyci ARA:AT4G31250-MONOMER.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiY4312_ARATH
    AccessioniPrimary (citable) accession number: C0LGR9
    Secondary accession number(s): O49575, Q0WRL7, Q67Z85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3