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Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g31250

Gene

At4g31250

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei394 – 3941ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3809ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G31250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At4g31250 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At4g31250
ORF Names:F8F16.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G31250.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 242216ExtracellularSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Topological domaini264 – 676413CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 676650Probable LRR receptor-like serine/threonine-protein kinase At4g31250PRO_0000387556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Modified residuei368 – 3681PhosphoserineBy similarity
Modified residuei446 – 4461PhosphoserineBy similarity
Modified residuei543 – 5431PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiC0LGR9.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G31250.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGR9.
SMRiC0LGR9. Positions 27-262, 288-640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati98 – 12225LRR 1Add
BLAST
Repeati123 – 14624LRR 2Add
BLAST
Repeati148 – 17124LRR 3Add
BLAST
Repeati172 – 19524LRR 4Add
BLAST
Repeati197 – 21822LRR 5Add
BLAST
Domaini366 – 640275Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116554.
InParanoidiC0LGR9.
OMAiHAQQFMV.
PhylomeDBiC0LGR9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: C0LGR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRDDKFPIV YSLLLIVLLF VSPIYGDGDA DALLKFKSSL VNASSLGGWD
60 70 80 90 100
SGEPPCSGDK GSDSKWKGVM CSNGSVFALR LENMSLSGEL DVQALGSIRG
110 120 130 140 150
LKSISFMRNH FEGKIPRGID GLVSLAHLYL AHNQFTGEID GDLFSGMKAL
160 170 180 190 200
LKVHLEGNRF SGEIPESLGK LPKLTELNLE DNMFTGKIPA FKQKNLVTVN
210 220 230 240 250
VANNQLEGRI PLTLGLMNIT FFSGNKGLCG APLLPCRYTR PPFFTVFLLA
260 270 280 290 300
LTILAVVVLI TVFLSVCILS RRQGKGQDQI QNHGVGHFHG QVYGQPEQQQ
310 320 330 340 350
HSEKSSQDSK VYRKLANETV QRDSTATSGA ISVGGLSPDE DKRGDQRKLH
360 370 380 390 400
FVRNDQERFT LQDMLRASAE VLGSGGFGSS YKAALSSGRA VVVKRFRFMS
410 420 430 440 450
NIGREEFYDH MKKIGRLSHP NLLPLIAFYY RKEEKLLVTN YISNGSLANL
460 470 480 490 500
LHANRTPGQV VLDWPIRLKI VRGVTRGLAY LYRVFPDLNL PHGHLKSSNV
510 520 530 540 550
LLDPNFEPLL TDYALVPVVN RDQSQQFMVA YKAPEFTQQD RTSRRSDVWS
560 570 580 590 600
LGILILEILT GKFPANYLRQ GKGADDELAA WVESVARTEW TADVFDKEMK
610 620 630 640 650
AGKEHEAQML KLLKIGLRCC DWDIEKRIEL HEAVDRIEEV DRDAGGGQES
660 670
VRSSYVTASD GDHRSSRAMT EEFSLM
Length:676
Mass (Da):75,235
Last modified:May 5, 2009 - v1
Checksum:i65162EF1D0782579
GO
Isoform 2 (identifier: C0LGR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     89-98: ELDVQALGSI → MERSDVFKRL

Note: No experimental confirmation available.
Show »
Length:588
Mass (Da):66,126
Checksum:iA2CA3D49FE525576
GO

Sequence cautioni

The sequence CAA16528.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB79843.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4882DL → RI in BAF00232 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 2. 1 PublicationVSP_038293Add
BLAST
Alternative sequencei89 – 9810ELDVQALGSI → MERSDVFKRL in isoform 2. 1 PublicationVSP_038294

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021633 Genomic DNA. Translation: CAA16528.1. Sequence problems.
AL161578 Genomic DNA. Translation: CAB79843.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE85882.1.
AK176198 mRNA. Translation: BAD43961.1.
AK176233 mRNA. Translation: BAD43996.1.
AK176245 mRNA. Translation: BAD44008.1.
AK176283 mRNA. Translation: BAD44046.1.
AK176290 mRNA. Translation: BAD44053.1.
AK176304 mRNA. Translation: BAD44067.1.
AK176329 mRNA. Translation: BAD44092.1.
AK221228 mRNA. Translation: BAD93819.1.
AK228286 mRNA. Translation: BAF00232.1.
FJ708761 mRNA. Translation: ACN59354.1.
PIRiT04492.
RefSeqiNP_567870.1. NM_119274.4. [C0LGR9-1]
UniGeneiAt.31759.

Genome annotation databases

EnsemblPlantsiAT4G31250.1; AT4G31250.1; AT4G31250. [C0LGR9-1]
GeneIDi829252.
KEGGiath:AT4G31250.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021633 Genomic DNA. Translation: CAA16528.1. Sequence problems.
AL161578 Genomic DNA. Translation: CAB79843.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE85882.1.
AK176198 mRNA. Translation: BAD43961.1.
AK176233 mRNA. Translation: BAD43996.1.
AK176245 mRNA. Translation: BAD44008.1.
AK176283 mRNA. Translation: BAD44046.1.
AK176290 mRNA. Translation: BAD44053.1.
AK176304 mRNA. Translation: BAD44067.1.
AK176329 mRNA. Translation: BAD44092.1.
AK221228 mRNA. Translation: BAD93819.1.
AK228286 mRNA. Translation: BAF00232.1.
FJ708761 mRNA. Translation: ACN59354.1.
PIRiT04492.
RefSeqiNP_567870.1. NM_119274.4. [C0LGR9-1]
UniGeneiAt.31759.

3D structure databases

ProteinModelPortaliC0LGR9.
SMRiC0LGR9. Positions 27-262, 288-640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G31250.1.

Proteomic databases

PRIDEiC0LGR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G31250.1; AT4G31250.1; AT4G31250. [C0LGR9-1]
GeneIDi829252.
KEGGiath:AT4G31250.

Organism-specific databases

GeneFarmi2307. 47.
TAIRiAT4G31250.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116554.
InParanoidiC0LGR9.
OMAiHAQQFMV.
PhylomeDBiC0LGR9.

Enzyme and pathway databases

BioCyciARA:AT4G31250-MONOMER.

Miscellaneous databases

PROiC0LGR9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.

Entry informationi

Entry nameiY4312_ARATH
AccessioniPrimary (citable) accession number: C0LGR9
Secondary accession number(s): O49575, Q0WRL7, Q67Z85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.