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C0LGR3

- Y4265_ARATH

UniProt

C0LGR3 - Y4265_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At4g26540

Gene

At4g26540

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei788 – 7881ATPPROSITE-ProRule annotation
    Active sitei883 – 8831Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi766 – 7749ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G26540-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At4g26540 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At4g26540
    ORF Names:M3E9.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G26540.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 10911067Probable LRR receptor-like serine/threonine-protein kinase At4g26540PRO_0000387553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
    Modified residuei831 – 8311PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiC0LGR3.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGR3.
    SMRiC0LGR3. Positions 24-1042.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 703679ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini725 – 1091367CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei704 – 72421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati33 – 5624LRR 1Add
    BLAST
    Repeati67 – 9125LRR 2Add
    BLAST
    Repeati92 – 11524LRR 3Add
    BLAST
    Repeati116 – 14025LRR 4Add
    BLAST
    Repeati142 – 16625LRR 5Add
    BLAST
    Repeati168 – 18821LRR 6Add
    BLAST
    Repeati190 – 21324LRR 7Add
    BLAST
    Repeati214 – 23724LRR 8Add
    BLAST
    Repeati239 – 26123LRR 9Add
    BLAST
    Repeati262 – 28524LRR 10Add
    BLAST
    Repeati287 – 30923LRR 11Add
    BLAST
    Repeati311 – 33222LRR 12Add
    BLAST
    Repeati333 – 35725LRR 13Add
    BLAST
    Repeati359 – 38325LRR 14Add
    BLAST
    Repeati385 – 40521LRR 15Add
    BLAST
    Repeati406 – 42924LRR 16Add
    BLAST
    Repeati431 – 45323LRR 17Add
    BLAST
    Repeati454 – 47724LRR 18Add
    BLAST
    Repeati478 – 50124LRR 19Add
    BLAST
    Repeati503 – 52422LRR 20Add
    BLAST
    Repeati525 – 54824LRR 21Add
    BLAST
    Repeati549 – 57224LRR 22Add
    BLAST
    Repeati574 – 59623LRR 23Add
    BLAST
    Repeati598 – 62023LRR 24Add
    BLAST
    Repeati621 – 64424LRR 25Add
    BLAST
    Repeati645 – 66824LRR 26Add
    BLAST
    Repeati669 – 69022LRR 27Add
    BLAST
    Domaini760 – 1046287Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 27 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116551.
    InParanoidiQ8W556.
    OMAiDSIMHEM.
    PhylomeDBiC0LGR3.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 2 hits.
    PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C0LGR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPNIYRLSF FSSLLCFFFI PCFSLDQQGQ ALLSWKSQLN ISGDAFSSWH     50
    VADTSPCNWV GVKCNRRGEV SEIQLKGMDL QGSLPVTSLR SLKSLTSLTL 100
    SSLNLTGVIP KEIGDFTELE LLDLSDNSLS GDIPVEIFRL KKLKTLSLNT 150
    NNLEGHIPME IGNLSGLVEL MLFDNKLSGE IPRSIGELKN LQVLRAGGNK 200
    NLRGELPWEI GNCENLVMLG LAETSLSGKL PASIGNLKRV QTIAIYTSLL 250
    SGPIPDEIGY CTELQNLYLY QNSISGSIPT TIGGLKKLQS LLLWQNNLVG 300
    KIPTELGNCP ELWLIDFSEN LLTGTIPRSF GKLENLQELQ LSVNQISGTI 350
    PEELTNCTKL THLEIDNNLI TGEIPSLMSN LRSLTMFFAW QNKLTGNIPQ 400
    SLSQCRELQA IDLSYNSLSG SIPKEIFGLR NLTKLLLLSN DLSGFIPPDI 450
    GNCTNLYRLR LNGNRLAGSI PSEIGNLKNL NFVDISENRL VGSIPPAISG 500
    CESLEFLDLH TNSLSGSLLG TTLPKSLKFI DFSDNALSST LPPGIGLLTE 550
    LTKLNLAKNR LSGEIPREIS TCRSLQLLNL GENDFSGEIP DELGQIPSLA 600
    ISLNLSCNRF VGEIPSRFSD LKNLGVLDVS HNQLTGNLNV LTDLQNLVSL 650
    NISYNDFSGD LPNTPFFRRL PLSDLASNRG LYISNAISTR PDPTTRNSSV 700
    VRLTILILVV VTAVLVLMAV YTLVRARAAG KQLLGEEIDS WEVTLYQKLD 750
    FSIDDIVKNL TSANVIGTGS SGVVYRITIP SGESLAVKKM WSKEESGAFN 800
    SEIKTLGSIR HRNIVRLLGW CSNRNLKLLF YDYLPNGSLS SRLHGAGKGG 850
    CVDWEARYDV VLGVAHALAY LHHDCLPTII HGDVKAMNVL LGPHFEPYLA 900
    DFGLARTISG YPNTGIDLAK PTNRPPMAGS YGYMAPEHAS MQRITEKSDV 950
    YSYGVVLLEV LTGKHPLDPD LPGGAHLVKW VRDHLAEKKD PSRLLDPRLD 1000
    GRTDSIMHEM LQTLAVAFLC VSNKANERPL MKDVVAMLTE IRHIDVGRSE 1050
    TEKIKAGGCG SKEPQQFMSN EKIINSHGSS NCSFAFSDDS V 1091
    Length:1,091
    Mass (Da):119,529
    Last modified:May 5, 2009 - v1
    Checksum:i061EFB0EDF281988
    GO

    Sequence cautioni

    The sequence AAL32011.1 differs from that shown. Reason: Frameshift at position 1084.
    The sequence CAA18216.1 differs from that shown. Reason: Frameshift at position 931.
    The sequence CAB79509.1 differs from that shown. Reason: Frameshift at position 931.
    The sequence CAA18216.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79509.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2211L → P in AAL32011. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022223 Genomic DNA. Translation: CAA18216.1. Sequence problems.
    AL161565 Genomic DNA. Translation: CAB79509.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85216.1.
    AF436829 mRNA. Translation: AAL32011.1. Frameshift.
    FJ708754 mRNA. Translation: ACN59348.1.
    PIRiT05050.
    RefSeqiNP_567748.5. NM_118787.5.
    UniGeneiAt.20959.

    Genome annotation databases

    EnsemblPlantsiAT4G26540.1; AT4G26540.1; AT4G26540.
    GeneIDi828760.
    KEGGiath:AT4G26540.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022223 Genomic DNA. Translation: CAA18216.1 . Sequence problems.
    AL161565 Genomic DNA. Translation: CAB79509.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85216.1 .
    AF436829 mRNA. Translation: AAL32011.1 . Frameshift.
    FJ708754 mRNA. Translation: ACN59348.1 .
    PIRi T05050.
    RefSeqi NP_567748.5. NM_118787.5.
    UniGenei At.20959.

    3D structure databases

    ProteinModelPortali C0LGR3.
    SMRi C0LGR3. Positions 24-1042.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi C0LGR3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G26540.1 ; AT4G26540.1 ; AT4G26540 .
    GeneIDi 828760.
    KEGGi ath:AT4G26540.

    Organism-specific databases

    GeneFarmi 624. 55.
    TAIRi AT4G26540.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116551.
    InParanoidi Q8W556.
    OMAi DSIMHEM.
    PhylomeDBi C0LGR3.

    Enzyme and pathway databases

    BioCyci ARA:AT4G26540-MONOMER.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 2 hits.
    PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiY4265_ARATH
    AccessioniPrimary (citable) accession number: C0LGR3
    Secondary accession number(s): O65580, Q8W556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3