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Protein

LRR receptor-like serine/threonine-protein kinase

Gene

RGI3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT) (PubMed:27229312, PubMed:27229311). Links RGF1 signal with its downstream components (PubMed:27229311).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei788ATPPROSITE-ProRule annotation1
Active sitei883Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi766 – 774ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
LRR receptor-like serine/threonine-protein kinaseCurated (EC:2.7.11.1Curated)
Alternative name(s):
LRR receptor-like serine/threonine-protein kinase At4g26540Curated
Protein RECEPTOR OF RGF11 Publication
Protein RGF1 INSENSITIVE 31 Publication
Gene namesi
Name:RGI31 Publication
Synonyms:RGFR11 Publication
Ordered Locus Names:At4g26540
ORF Names:M3E9.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G26540.
TAIRilocus:2131518. AT4G26540.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 703ExtracellularSequence analysisAdd BLAST679
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Topological domaini725 – 1091CytoplasmicSequence analysisAdd BLAST367

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000038755325 – 1091LRR receptor-like serine/threonine-protein kinaseAdd BLAST1067

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei831PhosphotyrosineBy similarity1
Modified residuei870PhosphotyrosineBy similarity1
Modified residuei933PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGR3.

PTM databases

iPTMnetiC0LGR3.

Expressioni

Gene expression databases

GenevisibleiC0LGR3. AT.

Interactioni

Protein-protein interaction databases

BioGridi14047. 1 interactor.
STRINGi3702.AT4G26540.1.

Structurei

Secondary structure

11091
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi59 – 64Combined sources6
Beta strandi68 – 77Combined sources10
Beta strandi97 – 103Combined sources7
Helixi111 – 115Combined sources5
Beta strandi121 – 123Combined sources3
Helixi135 – 139Combined sources5
Beta strandi144 – 147Combined sources4
Helixi159 – 163Combined sources5
Beta strandi169 – 171Combined sources3
Beta strandi178 – 180Combined sources3
Helixi183 – 187Combined sources5
Beta strandi193 – 195Combined sources3
Beta strandi201 – 205Combined sources5
Helixi208 – 212Combined sources5
Beta strandi218 – 220Combined sources3
Beta strandi223 – 228Combined sources6
Helixi232 – 236Combined sources5
Beta strandi242 – 244Combined sources3
Beta strandi247 – 250Combined sources4
Helixi256 – 260Combined sources5
Beta strandi266 – 268Combined sources3
Beta strandi271 – 274Combined sources4
Helixi280 – 284Combined sources5
Beta strandi290 – 292Combined sources3
Beta strandi299 – 301Combined sources3
Helixi304 – 308Combined sources5
Beta strandi314 – 316Combined sources3
Beta strandi323 – 325Combined sources3
Helixi328 – 332Combined sources5
Beta strandi338 – 340Combined sources3
Beta strandi347 – 349Combined sources3
Helixi352 – 356Combined sources5
Beta strandi362 – 364Combined sources3
Helixi376 – 380Combined sources5
Beta strandi386 – 388Combined sources3
Beta strandi391 – 396Combined sources6
Helixi400 – 404Combined sources5
Beta strandi410 – 412Combined sources3
Beta strandi415 – 418Combined sources4
Helixi424 – 428Combined sources5
Beta strandi434 – 436Combined sources3
Beta strandi439 – 444Combined sources6
Helixi448 – 452Combined sources5
Beta strandi458 – 460Combined sources3
Beta strandi463 – 466Combined sources4
Helixi472 – 476Combined sources5
Beta strandi482 – 484Combined sources3
Beta strandi487 – 490Combined sources4
Helixi496 – 500Combined sources5
Beta strandi506 – 508Combined sources3
Helixi520 – 522Combined sources3
Beta strandi529 – 531Combined sources3
Beta strandi534 – 537Combined sources4
Beta strandi538 – 540Combined sources3
Helixi543 – 547Combined sources5
Beta strandi553 – 555Combined sources3
Helixi567 – 571Combined sources5
Beta strandi577 – 579Combined sources3
Beta strandi582 – 585Combined sources4
Beta strandi586 – 588Combined sources3
Helixi591 – 595Combined sources5
Beta strandi601 – 604Combined sources4
Beta strandi611 – 613Combined sources3
Helixi616 – 620Combined sources5
Beta strandi626 – 628Combined sources3
Helixi639 – 641Combined sources3
Beta strandi649 – 651Combined sources3
Beta strandi658 – 661Combined sources4
Helixi665 – 669Combined sources5
Helixi672 – 676Combined sources5
Beta strandi678 – 683Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HYXX-ray2.60B57-689[»]
5HZ0X-ray2.56B57-689[»]
5HZ1X-ray2.59B57-689[»]
5HZ3X-ray2.86B57-689[»]
ProteinModelPortaliC0LGR3.
SMRiC0LGR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 56LRR 1Add BLAST24
Repeati67 – 91LRR 2Add BLAST25
Repeati92 – 115LRR 3Add BLAST24
Repeati116 – 140LRR 4Add BLAST25
Repeati142 – 166LRR 5Add BLAST25
Repeati168 – 188LRR 6Add BLAST21
Repeati190 – 213LRR 7Add BLAST24
Repeati214 – 237LRR 8Add BLAST24
Repeati239 – 261LRR 9Add BLAST23
Repeati262 – 285LRR 10Add BLAST24
Repeati287 – 309LRR 11Add BLAST23
Repeati311 – 332LRR 12Add BLAST22
Repeati333 – 357LRR 13Add BLAST25
Repeati359 – 383LRR 14Add BLAST25
Repeati385 – 405LRR 15Add BLAST21
Repeati406 – 429LRR 16Add BLAST24
Repeati431 – 453LRR 17Add BLAST23
Repeati454 – 477LRR 18Add BLAST24
Repeati478 – 501LRR 19Add BLAST24
Repeati503 – 524LRR 20Add BLAST22
Repeati525 – 548LRR 21Add BLAST24
Repeati549 – 572LRR 22Add BLAST24
Repeati574 – 596LRR 23Add BLAST23
Repeati598 – 620LRR 24Add BLAST23
Repeati621 – 644LRR 25Add BLAST24
Repeati645 – 668LRR 26Add BLAST24
Repeati669 – 690LRR 27Add BLAST22
Domaini760 – 1046Protein kinasePROSITE-ProRule annotationAdd BLAST287

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIZE. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiC0LGR3.
OMAiWVREHVQ.
OrthoDBiEOG0936016M.
PhylomeDBiC0LGR3.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF13855. LRR_8. 3 hits.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 8 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPNIYRLSF FSSLLCFFFI PCFSLDQQGQ ALLSWKSQLN ISGDAFSSWH
60 70 80 90 100
VADTSPCNWV GVKCNRRGEV SEIQLKGMDL QGSLPVTSLR SLKSLTSLTL
110 120 130 140 150
SSLNLTGVIP KEIGDFTELE LLDLSDNSLS GDIPVEIFRL KKLKTLSLNT
160 170 180 190 200
NNLEGHIPME IGNLSGLVEL MLFDNKLSGE IPRSIGELKN LQVLRAGGNK
210 220 230 240 250
NLRGELPWEI GNCENLVMLG LAETSLSGKL PASIGNLKRV QTIAIYTSLL
260 270 280 290 300
SGPIPDEIGY CTELQNLYLY QNSISGSIPT TIGGLKKLQS LLLWQNNLVG
310 320 330 340 350
KIPTELGNCP ELWLIDFSEN LLTGTIPRSF GKLENLQELQ LSVNQISGTI
360 370 380 390 400
PEELTNCTKL THLEIDNNLI TGEIPSLMSN LRSLTMFFAW QNKLTGNIPQ
410 420 430 440 450
SLSQCRELQA IDLSYNSLSG SIPKEIFGLR NLTKLLLLSN DLSGFIPPDI
460 470 480 490 500
GNCTNLYRLR LNGNRLAGSI PSEIGNLKNL NFVDISENRL VGSIPPAISG
510 520 530 540 550
CESLEFLDLH TNSLSGSLLG TTLPKSLKFI DFSDNALSST LPPGIGLLTE
560 570 580 590 600
LTKLNLAKNR LSGEIPREIS TCRSLQLLNL GENDFSGEIP DELGQIPSLA
610 620 630 640 650
ISLNLSCNRF VGEIPSRFSD LKNLGVLDVS HNQLTGNLNV LTDLQNLVSL
660 670 680 690 700
NISYNDFSGD LPNTPFFRRL PLSDLASNRG LYISNAISTR PDPTTRNSSV
710 720 730 740 750
VRLTILILVV VTAVLVLMAV YTLVRARAAG KQLLGEEIDS WEVTLYQKLD
760 770 780 790 800
FSIDDIVKNL TSANVIGTGS SGVVYRITIP SGESLAVKKM WSKEESGAFN
810 820 830 840 850
SEIKTLGSIR HRNIVRLLGW CSNRNLKLLF YDYLPNGSLS SRLHGAGKGG
860 870 880 890 900
CVDWEARYDV VLGVAHALAY LHHDCLPTII HGDVKAMNVL LGPHFEPYLA
910 920 930 940 950
DFGLARTISG YPNTGIDLAK PTNRPPMAGS YGYMAPEHAS MQRITEKSDV
960 970 980 990 1000
YSYGVVLLEV LTGKHPLDPD LPGGAHLVKW VRDHLAEKKD PSRLLDPRLD
1010 1020 1030 1040 1050
GRTDSIMHEM LQTLAVAFLC VSNKANERPL MKDVVAMLTE IRHIDVGRSE
1060 1070 1080 1090
TEKIKAGGCG SKEPQQFMSN EKIINSHGSS NCSFAFSDDS V
Length:1,091
Mass (Da):119,529
Last modified:May 5, 2009 - v1
Checksum:i061EFB0EDF281988
GO

Sequence cautioni

The sequence AAL32011 differs from that shown. Reason: Frameshift at position 1084.Curated
The sequence CAA18216 differs from that shown. Reason: Frameshift at position 931.Curated
The sequence CAA18216 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79509 differs from that shown. Reason: Frameshift at position 931.Curated
The sequence CAB79509 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221L → P in AAL32011 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022223 Genomic DNA. Translation: CAA18216.1. Sequence problems.
AL161565 Genomic DNA. Translation: CAB79509.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE85216.1.
AF436829 mRNA. Translation: AAL32011.1. Frameshift.
FJ708754 mRNA. Translation: ACN59348.1.
PIRiT05050.
RefSeqiNP_567748.5. NM_118787.6.
UniGeneiAt.20959.

Genome annotation databases

EnsemblPlantsiAT4G26540.1; AT4G26540.1; AT4G26540.
GeneIDi828760.
GrameneiAT4G26540.1; AT4G26540.1; AT4G26540.
KEGGiath:AT4G26540.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRGI3_ARATH
AccessioniPrimary (citable) accession number: C0LGR3
Secondary accession number(s): O65580, Q8W556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: July 5, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families