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C0LGQ5

- GSO1_ARATH

UniProt

C0LGQ5 - GSO1_ARATH

Protein

LRR receptor-like serine/threonine-protein kinase GSO1

Gene

GSO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Together with GSO2, receptor-like serine/threonine-kinase required during the development of the epidermal surface in embryos and cotyledons.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei979 – 9791ATPPROSITE-ProRule annotation
    Active sitei1084 – 10841Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi957 – 9659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. epidermis development Source: TAIR

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G20140-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LRR receptor-like serine/threonine-protein kinase GSO1 (EC:2.7.11.1)
    Alternative name(s):
    Protein GASSHO 1
    Gene namesi
    Name:GSO1
    Ordered Locus Names:At4g20140
    ORF Names:F1C12.60
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G20140.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype during embryogenesis and seedling development. Gso1 and gso2 double mutants produce slightly contorted seeds, with abnormally shaped embryos and seedlings; adhesion between cotyledons and the peripheral tissue of the endosperm, short hypocotyl, and concave cotyledons sometimes fused, with compressed epidermal cells, endosperm tissue partially adherent to the surface of the cotyledons, and a rough surface.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 12491231LRR receptor-like serine/threonine-protein kinase GSO1PRO_0000387513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi693 – 6931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi779 – 7791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
    Modified residuei948 – 9481PhosphothreonineBy similarity
    Modified residuei1027 – 10271PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiC0LGQ5.
    PRIDEiC0LGQ5.

    Expressioni

    Tissue specificityi

    Mostly expressed in siliques, seeds, developing embryos and seedlings, detected in flower buds and roots, but not in leaves or stems.1 Publication

    Developmental stagei

    In flower buds, localized in filaments and stigmas. During embryogenesis, uniform expression from the globular embryo to the mature cotyledonary embryo. After germination, detected in whole cotyledons and in the hypocotyl.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT4G20140.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGQ5.
    SMRiC0LGQ5. Positions 23-852, 861-1249.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 876858ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini898 – 1249352CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei877 – 89721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati94 – 11825LRR 1Add
    BLAST
    Repeati119 – 14224LRR 2Add
    BLAST
    Repeati144 – 16623LRR 3Add
    BLAST
    Repeati168 – 19023LRR 4Add
    BLAST
    Repeati191 – 21424LRR 5Add
    BLAST
    Repeati216 – 23823LRR 6Add
    BLAST
    Repeati239 – 26224LRR 7Add
    BLAST
    Repeati264 – 28522LRR 8Add
    BLAST
    Repeati286 – 31025LRR 9Add
    BLAST
    Repeati312 – 33423LRR 10Add
    BLAST
    Repeati336 – 35924LRR 11Add
    BLAST
    Repeati360 – 38324LRR 12Add
    BLAST
    Repeati385 – 40723LRR 13Add
    BLAST
    Repeati408 – 43124LRR 14Add
    BLAST
    Repeati433 – 45523LRR 15Add
    BLAST
    Repeati457 – 47923LRR 16Add
    BLAST
    Repeati480 – 50324LRR 17Add
    BLAST
    Repeati505 – 52723LRR 18Add
    BLAST
    Repeati528 – 55124LRR 19Add
    BLAST
    Repeati553 – 57422LRR 20Add
    BLAST
    Repeati576 – 59823LRR 21Add
    BLAST
    Repeati599 – 62224LRR 22Add
    BLAST
    Repeati623 – 64624LRR 23Add
    BLAST
    Repeati648 – 67023LRR 24Add
    BLAST
    Repeati671 – 69424LRR 25Add
    BLAST
    Repeati696 – 71823LRR 26Add
    BLAST
    Repeati719 – 74224LRR 27Add
    BLAST
    Repeati744 – 76623LRR 28Add
    BLAST
    Repeati767 – 79125LRR 29Add
    BLAST
    Repeati792 – 81524LRR 30Add
    BLAST
    Repeati817 – 83822LRR 31Add
    BLAST
    Domaini951 – 1240290Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 31 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116551.
    InParanoidiQ9SN91.
    OMAiHDKSFAR.
    PhylomeDBiC0LGQ5.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00560. LRR_1. 2 hits.
    PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 4 hits.
    PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C0LGQ5-1 [UniParc]FASTAAdd to Basket

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    MQPLVLLLLF ILCFSGLGQP GIINNDLQTL LEVKKSLVTN PQEDDPLRQW     50
    NSDNINYCSW TGVTCDNTGL FRVIALNLTG LGLTGSISPW FGRFDNLIHL 100
    DLSSNNLVGP IPTALSNLTS LESLFLFSNQ LTGEIPSQLG SLVNIRSLRI 150
    GDNELVGDIP ETLGNLVNLQ MLALASCRLT GPIPSQLGRL VRVQSLILQD 200
    NYLEGPIPAE LGNCSDLTVF TAAENMLNGT IPAELGRLEN LEILNLANNS 250
    LTGEIPSQLG EMSQLQYLSL MANQLQGLIP KSLADLGNLQ TLDLSANNLT 300
    GEIPEEFWNM SQLLDLVLAN NHLSGSLPKS ICSNNTNLEQ LVLSGTQLSG 350
    EIPVELSKCQ SLKQLDLSNN SLAGSIPEAL FELVELTDLY LHNNTLEGTL 400
    SPSISNLTNL QWLVLYHNNL EGKLPKEISA LRKLEVLFLY ENRFSGEIPQ 450
    EIGNCTSLKM IDMFGNHFEG EIPPSIGRLK ELNLLHLRQN ELVGGLPASL 500
    GNCHQLNILD LADNQLSGSI PSSFGFLKGL EQLMLYNNSL QGNLPDSLIS 550
    LRNLTRINLS HNRLNGTIHP LCGSSSYLSF DVTNNGFEDE IPLELGNSQN 600
    LDRLRLGKNQ LTGKIPWTLG KIRELSLLDM SSNALTGTIP LQLVLCKKLT 650
    HIDLNNNFLS GPIPPWLGKL SQLGELKLSS NQFVESLPTE LFNCTKLLVL 700
    SLDGNSLNGS IPQEIGNLGA LNVLNLDKNQ FSGSLPQAMG KLSKLYELRL 750
    SRNSLTGEIP VEIGQLQDLQ SALDLSYNNF TGDIPSTIGT LSKLETLDLS 800
    HNQLTGEVPG SVGDMKSLGY LNVSFNNLGG KLKKQFSRWP ADSFLGNTGL 850
    CGSPLSRCNR VRSNNKQQGL SARSVVIISA ISALTAIGLM ILVIALFFKQ 900
    RHDFFKKVGH GSTAYTSSSS SSQATHKPLF RNGASKSDIR WEDIMEATHN 950
    LSEEFMIGSG GSGKVYKAEL ENGETVAVKK ILWKDDLMSN KSFSREVKTL 1000
    GRIRHRHLVK LMGYCSSKSE GLNLLIYEYM KNGSIWDWLH EDKPVLEKKK 1050
    KLLDWEARLR IAVGLAQGVE YLHHDCVPPI VHRDIKSSNV LLDSNMEAHL 1100
    GDFGLAKVLT ENCDTNTDSN TWFACSYGYI APEYAYSLKA TEKSDVYSMG 1150
    IVLMEIVTGK MPTDSVFGAE MDMVRWVETH LEVAGSARDK LIDPKLKPLL 1200
    PFEEDAACQV LEIALQCTKT SPQERPSSRQ ACDSLLHVYN NRTAGYKKL 1249
    Length:1,249
    Mass (Da):137,288
    Last modified:May 5, 2009 - v1
    Checksum:i9B4C4928C8A10E95
    GO

    Sequence cautioni

    The sequence CAA18239.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79014.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022224 Genomic DNA. Translation: CAA18239.1. Sequence problems.
    AL161552 Genomic DNA. Translation: CAB79014.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE84279.1.
    FJ708746 mRNA. Translation: ACN59340.1.
    PIRiT05322.
    RefSeqiNP_193747.2. NM_118133.2.
    UniGeneiAt.2179.
    At.22288.

    Genome annotation databases

    EnsemblPlantsiAT4G20140.1; AT4G20140.1; AT4G20140.
    GeneIDi827760.
    KEGGiath:AT4G20140.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022224 Genomic DNA. Translation: CAA18239.1 . Sequence problems.
    AL161552 Genomic DNA. Translation: CAB79014.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE84279.1 .
    FJ708746 mRNA. Translation: ACN59340.1 .
    PIRi T05322.
    RefSeqi NP_193747.2. NM_118133.2.
    UniGenei At.2179.
    At.22288.

    3D structure databases

    ProteinModelPortali C0LGQ5.
    SMRi C0LGQ5. Positions 23-852, 861-1249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT4G20140.1-P.

    Proteomic databases

    PaxDbi C0LGQ5.
    PRIDEi C0LGQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G20140.1 ; AT4G20140.1 ; AT4G20140 .
    GeneIDi 827760.
    KEGGi ath:AT4G20140.

    Organism-specific databases

    GeneFarmi 663. 55.
    TAIRi AT4G20140.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116551.
    InParanoidi Q9SN91.
    OMAi HDKSFAR.
    PhylomeDBi C0LGQ5.

    Enzyme and pathway databases

    BioCyci ARA:AT4G20140-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00560. LRR_1. 2 hits.
    PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 4 hits.
    PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "GASSHO1 and GASSHO2 encoding a putative leucine-rich repeat transmembrane-type receptor kinase are essential for the normal development of the epidermal surface in Arabidopsis embryos."
      Tsuwamoto R., Fukuoka H., Takahata Y.
      Plant J. 54:30-42(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGSO1_ARATH
    AccessioniPrimary (citable) accession number: C0LGQ5
    Secondary accession number(s): Q9SN91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3