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Protein

Protein MALE DISCOVERER 2

Gene

MDIS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the pollen tube perception of the female signal by binding an unidentified female attractant (PubMed:26863186). May be involved in the regulation of root hairs development (PubMed:16367956).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

GO - Molecular functioni

GO - Biological processi

  • root hair cell differentiation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G18640-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MALE DISCOVERER 2
Short name:
AtMDIS2
Alternative name(s):
Probable LRR receptor-like serine/threonine-protein kinase MRH11 Publication (EC:2.7.11.1Curated)
Protein MORPHOGENESIS OF ROOT HAIR 11 Publication
Gene namesi
Name:MDIS2
Synonyms:MRH11 Publication
Ordered Locus Names:At4g18640
ORF Names:F28A21.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G18640.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 323298ExtracellularSequence analysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence analysisAdd
BLAST
Topological domaini345 – 678334CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endomembrane system Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
  • pollen tube Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Short straight root hairs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 678653Protein MALE DISCOVERER 2PRO_0000387516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiC0LGQ4.
PRIDEiC0LGQ4.

PTM databases

iPTMnetiC0LGQ4.

Expressioni

Tissue specificityi

Expressed in pollen tubes and seedlings.1 Publication

Gene expression databases

GenevisibleiC0LGQ4. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G18640.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGQ4.
SMRiC0LGQ4. Positions 26-197, 373-654.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati71 – 9424LRR 1Sequence analysisAdd
BLAST
Repeati95 – 11723LRR 2Sequence analysisAdd
BLAST
Repeati119 – 14123LRR 3Sequence analysisAdd
BLAST
Repeati143 – 16422LRR 4Sequence analysisAdd
BLAST
Domaini346 – 651306Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHG1. Eukaryota.
ENOG410ZQU1. LUCA.
HOGENOMiHOG000240929.
InParanoidiC0LGQ4.
OMAiMWKMVDA.
OrthoDBiEOG0936050E.
PhylomeDBiC0LGQ4.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGCGFHFPW FFFLIIGLQA PLSLSLTSQG SALLKFRARV NSDPHGTLAN
60 70 80 90 100
WNVSGINDLC YWSGVTCVDG KVQILDLSGY SLEGTLAPEL SQLSDLRSLI
110 120 130 140 150
LSRNHFSGGI PKEYGSFENL EVLDLRENDL SGQIPPELSN GLSLKHLLLS
160 170 180 190 200
GNKFSDDMRI KIVRLQSSYE VRLKKSPKLS PLAVLGCINR KLGHCVSRNR
210 220 230 240 250
IIQVKKVEAI VFRIKATSRR FLKAFPSFLE ETDIYKRREL LEETSNLAAE
260 270 280 290 300
PAPSAPSPSP GIITEASPRS SGSFPAVTNA KKRRPPLVPP VPSPDKGSTS
310 320 330 340 350
PDISKNQPQD NKQSKGSKHV WLYVVIAVAS FVGLLIIVAV IFFCRKRAVK
360 370 380 390 400
SIGPWKTGLS GQLQKAFVTG VPKLNRSELE TACEDFSNII ETFDGYTVYK
410 420 430 440 450
GTLSSGVEIA VASTAIAESK EWTRAMEMAY RRKIDTLSRI NHKNFVNLIG
460 470 480 490 500
YCEEDDPFNR MMVFEYAPNG TLFEHLHDKE TEHLDWSARM RIIMGTAYCL
510 520 530 540 550
QHMHGMNPPM AHTDFNSSEI YLTDDYAAKV SEIPFNLEAR LNPKKHVSGD
560 570 580 590 600
LEQTSLLLPP EPEANVHSFG VLMLEIISGK LSFSDEYGSI EQWASKYLEK
610 620 630 640 650
DDLGEMIDPS LKTFKEEELE VICDVIRECL KTEQRQRPSM KDVAEQLKQV
660 670
INITPEKATP RSSPLWWAEL EILSSEAT
Length:678
Mass (Da):75,820
Last modified:May 5, 2009 - v1
Checksum:i4D792304B01F4C13
GO

Sequence cautioni

The sequence CAB37449 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB78866 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035526 Genomic DNA. Translation: CAB37449.1. Sequence problems.
AL161549 Genomic DNA. Translation: CAB78866.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE84071.1.
FJ708745 mRNA. Translation: ACN59339.1.
PIRiT04856.
RefSeqiNP_193599.3. NM_117980.4.
UniGeneiAt.32880.

Genome annotation databases

EnsemblPlantsiAT4G18640.1; AT4G18640.1; AT4G18640.
GeneIDi827598.
GrameneiAT4G18640.1; AT4G18640.1; AT4G18640.
KEGGiath:AT4G18640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035526 Genomic DNA. Translation: CAB37449.1. Sequence problems.
AL161549 Genomic DNA. Translation: CAB78866.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE84071.1.
FJ708745 mRNA. Translation: ACN59339.1.
PIRiT04856.
RefSeqiNP_193599.3. NM_117980.4.
UniGeneiAt.32880.

3D structure databases

ProteinModelPortaliC0LGQ4.
SMRiC0LGQ4. Positions 26-197, 373-654.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G18640.1.

PTM databases

iPTMnetiC0LGQ4.

Proteomic databases

PaxDbiC0LGQ4.
PRIDEiC0LGQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G18640.1; AT4G18640.1; AT4G18640.
GeneIDi827598.
GrameneiAT4G18640.1; AT4G18640.1; AT4G18640.
KEGGiath:AT4G18640.

Organism-specific databases

TAIRiAT4G18640.

Phylogenomic databases

eggNOGiENOG410IHG1. Eukaryota.
ENOG410ZQU1. LUCA.
HOGENOMiHOG000240929.
InParanoidiC0LGQ4.
OMAiMWKMVDA.
OrthoDBiEOG0936050E.
PhylomeDBiC0LGQ4.

Enzyme and pathway databases

BioCyciARA:AT4G18640-MONOMER.

Miscellaneous databases

PROiC0LGQ4.

Gene expression databases

GenevisibleiC0LGQ4. AT.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDIS2_ARATH
AccessioniPrimary (citable) accession number: C0LGQ4
Secondary accession number(s): Q9M0L9, Q9SN49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.