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C0LGP9

- IMK3_ARATH

UniProt

C0LGP9 - IMK3_ARATH

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Protein

Probable leucine-rich repeat receptor-like protein kinase IMK3

Gene

IMK3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Can phosphorylate AGL24.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei516 – 5161ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi494 – 5029ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine-rich repeat receptor-like protein kinase IMK3 (EC:2.7.11.1)
Alternative name(s):
Protein INFLORESCENCE MERISTEM RECEPTOR-LIKE KINASE 3
Protein MERISTEMATIC RECEPTOR-LIKE KINASE
Gene namesi
Name:IMK3
Synonyms:MRLK
Ordered Locus Names:At3g56100
ORF Names:F18O21.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G56100.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini49 – 409361ExtracellularSequence AnalysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Topological domaini431 – 784354CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848Sequence AnalysisAdd
BLAST
Chaini49 – 784736Probable leucine-rich repeat receptor-like protein kinase IMK3PRO_0000389458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiC0LGP9.

Expressioni

Tissue specificityi

Expressed in meristems, including roots, vegetative, inflorescence and floral meristems, and in embryos.2 Publications

Interactioni

Subunit structurei

Interacts with AGL24.1 Publication

Protein-protein interaction databases

BioGridi10092. 3 interactions.
STRINGi3702.AT3G56100.1-P.

Structurei

3D structure databases

ProteinModelPortaliC0LGP9.
SMRiC0LGP9. Positions 59-374, 458-760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 14823LRR 1Add
BLAST
Repeati150 – 17223LRR 2Add
BLAST
Repeati174 – 19724LRR 3Add
BLAST
Repeati198 – 22023LRR 4Add
BLAST
Repeati222 – 24221LRR 5Add
BLAST
Repeati247 – 26822LRR 6Add
BLAST
Repeati271 – 29424LRR 7Add
BLAST
Repeati295 – 31723LRR 8Add
BLAST
Repeati319 – 34224LRR 9Add
BLAST
Repeati343 – 36523LRR 10Add
BLAST
Domaini488 – 773286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive. Lacks the conserved Asp active site at position 612, which is replaced by an Asn residue. However, according to , the kinase activity is conserved.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiC0LGP9.
PhylomeDBiC0LGP9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFITQNQAI TSLSMINTDI DQPKASLRSR FLLHLIICLL FFVPPCSSQA
60 70 80 90 100
WDGVVITQAD YQGLQAVKQE LIDPRGFLRS WNGSGFSACS GGWAGIKCAQ
110 120 130 140 150
GQVIVIQLPW KSLGGRISEK IGQLQALRKL SLHDNNLGGS IPMSLGLIPN
160 170 180 190 200
LRGVQLFNNR LTGSIPASLG VSHFLQTLDL SNNLLSEIIP PNLADSSKLL
210 220 230 240 250
RLNLSFNSLS GQIPVSLSRS SSLQFLALDH NNLSGPILDT WGSKSLNLRV
260 270 280 290 300
LSLDHNSLSG PFPFSLCNLT QLQDFSFSHN RIRGTLPSEL SKLTKLRKMD
310 320 330 340 350
ISGNSVSGHI PETLGNISSL IHLDLSQNKL TGEIPISISD LESLNFFNVS
360 370 380 390 400
YNNLSGPVPT LLSQKFNSSS FVGNSLLCGY SVSTPCPTLP SPSPEKERKP
410 420 430 440 450
SHRNLSTKDI ILIASGALLI VMLILVCVLC CLLRKKANET KAKGGEAGPG
460 470 480 490 500
AVAAKTEKGG EAEAGGETGG KLVHFDGPMA FTADDLLCAT AEIMGKSTYG
510 520 530 540 550
TVYKATLEDG SQVAVKRLRE KITKSQKEFE NEINVLGRIR HPNLLALRAY
560 570 580 590 600
YLGPKGEKLV VFDYMSRGSL ATFLHARGPD VHINWPTRMS LIKGMARGLF
610 620 630 640 650
YLHTHANIIH GNLTSSNVLL DENITAKISD YGLSRLMTAA AGSSVIATAG
660 670 680 690 700
ALGYRAPELS KLKKANTKTD VYSLGVIILE LLTGKSPSEA LNGVDLPQWV
710 720 730 740 750
ATAVKEEWTN EVFDLELLND VNTMGDEILN TLKLALHCVD ATPSTRPEAQ
760 770 780
QVMTQLGEIR PEETTATTSE PLIDVPEASA STSQ
Length:784
Mass (Da):84,687
Last modified:May 5, 2009 - v1
Checksum:i6F9B3F69661F2CFF
GO

Sequence cautioni

The sequence AEE79477.1 differs from that shown. Reason: Frameshift at positions 275 and 520. Curated
The sequence AEE79477.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAD94529.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB87409.1 differs from that shown. Reason: Frameshift at positions 275 and 520. Curated
The sequence CAB87409.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163763 Genomic DNA. Translation: CAB87409.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79477.1. Sequence problems.
FJ708740 mRNA. Translation: ACN59334.1.
AK118661 mRNA. Translation: BAC43256.1.
AK221981 mRNA. Translation: BAD94529.1. Different initiation.
BT005241 mRNA. Translation: AAO63305.1.
PIRiT47727.
RefSeqiNP_191169.1. NM_115468.2.
UniGeneiAt.34964.

Genome annotation databases

GeneIDi824776.
KEGGiath:AT3G56100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163763 Genomic DNA. Translation: CAB87409.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE79477.1 . Sequence problems.
FJ708740 mRNA. Translation: ACN59334.1 .
AK118661 mRNA. Translation: BAC43256.1 .
AK221981 mRNA. Translation: BAD94529.1 . Different initiation.
BT005241 mRNA. Translation: AAO63305.1 .
PIRi T47727.
RefSeqi NP_191169.1. NM_115468.2.
UniGenei At.34964.

3D structure databases

ProteinModelPortali C0LGP9.
SMRi C0LGP9. Positions 59-374, 458-760.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10092. 3 interactions.
STRINGi 3702.AT3G56100.1-P.

Proteomic databases

PRIDEi C0LGP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 824776.
KEGGi ath:AT3G56100.

Organism-specific databases

GeneFarmi 2317. 47.
TAIRi AT3G56100.

Phylogenomic databases

InParanoidi C0LGP9.
PhylomeDBi C0LGP9.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 562-784.
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 562-784.
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-784.
    Strain: cv. Columbia.
  7. "Structural and functional analysis of the receptor-like kinase genes expressed at Arabidopsis inflorescence."
    Takemura M., Kohchi T., Kanamoto H., Asai T., Nemoto K., Yokota A.
    (In) Proceedings of the 9th international conference on Arabidopsis research, abstract#501708527, Madison (1998)
    Cited for: TISSUE SPECIFICITY.
  8. "Analysis of the receptor-like kinase gene expressed in the meristems."
    Takemura M., Kanamoto H., Hasegawa M., Yokota A., Kohchi T.
    (In) Proceedings of the 10th international conference on Arabidopsis research, abstract#12-15, Melbourne (1999)
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. "Functional analysis of the receptor-like kinase gene expressed in both shoot and root apical meristems."
    Takemura M., Tani E., Takeda Y., Yokota A., Kohchi T.
    (In) Proceedings of the 11th international conference on Arabidopsis research, abstract#295, Madison (2000)
    Cited for: FUNCTION, AUTOPHOSPHORYLATION, INTERACTION WITH AGL24, ACTIVITY.

Entry informationi

Entry nameiIMK3_ARATH
AccessioniPrimary (citable) accession number: C0LGP9
Secondary accession number(s): F4IY70
, Q56WQ4, Q8GWS6, Q9LYN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3