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C0LGH8

- Y1634_ARATH

UniProt

C0LGH8 - Y1634_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g63430

Gene

At1g63430

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G63430-MONOMER.
    ARA:GQT-2270-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At1g63430 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At1g63430
    ORF Names:F2K11.19
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G63430.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 664642Probable LRR receptor-like serine/threonine-protein kinase At1g63430PRO_0000387538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiC0LGH8.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G63430.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGH8.
    SMRiC0LGH8. Positions 27-230, 345-650.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 288266ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 664355CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati94 – 11623LRR 1Add
    BLAST
    Repeati118 – 14023LRR 2Add
    BLAST
    Repeati142 – 16524LRR 3Add
    BLAST
    Repeati166 – 17813LRR 4Add
    BLAST
    Domaini360 – 642283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 4 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305556.
    HOGENOMiHOG000240929.
    InParanoidiQ8GY10.
    PhylomeDBiC0LGH8.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: C0LGH8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSKYFCSLA LVLGLFFVSC DGFASNEVQA LRRFKEAIYE DPLLVMSNWN    50
    DPNSDPCDWT GIYCSPSKDH VIKINISASS IKGFLAPELG QITYLQELIL 100
    HGNILIGTIP KEIGNLKNLK ILDLGNNHLM GPIPAEIGSL SGIMIINLQS 150
    NGLTGKLPAE LGNLKYLREL HIDRNRLQGS LLVAGASGYQ SKVYSSNSSA 200
    NIAGLCKSLK VADFSYNFFV GNIPKCLENL PRTSFQGNCM QNKDLKHRSS 250
    SQCANAQLVK THGSPSAAPK HQSAQMVAKH HRASKPKWLL ALEIVTGSMV 300
    GLLLLVALFS AVHRWNNRST LIIPWKKSSS EKEKFTVYVD SEMLKDVSRL 350
    TRQELEVACE DFSNIIGLSA DSQIYKGTLK GGSEIAVISL CVKEEDWTGY 400
    LELYFQREVA DLARLNHENT AKLLGYCKEI SPFTRMLVFE YASNGTLYEH 450
    LHYGEAALVS WARRMKIVIG IARGLKYLHM ELDPPFTISE LSSNAIYLTE 500
    DFTPKLVDFE CWKTILARSE KNLRNISSQG SICVLPNGME SRYLDVSGNI 550
    YAFGILLLEI VSGRPPYCKD KGFLIEWAKE FLEAPEAMSG LVDPELKHFN 600
    QEDLETVCEV ASQCLNRDPT NNNNNHNKPS VQELCETLES RISLSISAEL 650
    RSSSLAWAEL ALDS 664
    Length:664
    Mass (Da):73,910
    Last modified:May 5, 2009 - v1
    Checksum:i8520F165DA7CB366
    GO

    Sequence cautioni

    The sequence AAF19706.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501N → D in BAC42570. (PubMed:11910074)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008047 Genomic DNA. Translation: AAF19706.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE34098.1.
    AK117932 mRNA. Translation: BAC42570.1.
    FJ708668 mRNA. Translation: ACN59263.1.
    RefSeqiNP_176532.2. NM_105022.2. [C0LGH8-1]
    UniGeneiAt.14999.

    Genome annotation databases

    EnsemblPlantsiAT1G63430.1; AT1G63430.1; AT1G63430. [C0LGH8-1]
    GeneIDi842649.
    KEGGiath:AT1G63430.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008047 Genomic DNA. Translation: AAF19706.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE34098.1 .
    AK117932 mRNA. Translation: BAC42570.1 .
    FJ708668 mRNA. Translation: ACN59263.1 .
    RefSeqi NP_176532.2. NM_105022.2. [C0LGH8-1 ]
    UniGenei At.14999.

    3D structure databases

    ProteinModelPortali C0LGH8.
    SMRi C0LGH8. Positions 27-230, 345-650.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G63430.1-P.

    Proteomic databases

    PRIDEi C0LGH8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G63430.1 ; AT1G63430.1 ; AT1G63430 . [C0LGH8-1 ]
    GeneIDi 842649.
    KEGGi ath:AT1G63430.

    Organism-specific databases

    GeneFarmi 693. 50.
    TAIRi AT1G63430.

    Phylogenomic databases

    eggNOGi NOG305556.
    HOGENOMi HOG000240929.
    InParanoidi Q8GY10.
    PhylomeDBi C0LGH8.

    Enzyme and pathway databases

    BioCyci ARA:AT1G63430-MONOMER.
    ARA:GQT-2270-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiY1634_ARATH
    AccessioniPrimary (citable) accession number: C0LGH8
    Secondary accession number(s): Q8GY10, Q9SH29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3