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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g63430

Gene

At1g63430

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G63430-MONOMER.
ARA:GQT-2270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g63430 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g63430
ORF Names:F2K11.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G63430.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 288266ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Topological domaini310 – 664355CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 664642Probable LRR receptor-like serine/threonine-protein kinase At1g63430PRO_0000387538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiC0LGH8.

Expressioni

Gene expression databases

ExpressionAtlasiC0LGH8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G63430.2.

Structurei

3D structure databases

ProteinModelPortaliC0LGH8.
SMRiC0LGH8. Positions 27-230, 345-620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati94 – 11623LRR 1Add
BLAST
Repeati118 – 14023LRR 2Add
BLAST
Repeati142 – 16524LRR 3Add
BLAST
Repeati166 – 17813LRR 4Add
BLAST
Domaini360 – 642283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305556.
HOGENOMiHOG000240929.
InParanoidiC0LGH8.
PhylomeDBiC0LGH8.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: C0LGH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSKYFCSLA LVLGLFFVSC DGFASNEVQA LRRFKEAIYE DPLLVMSNWN
60 70 80 90 100
DPNSDPCDWT GIYCSPSKDH VIKINISASS IKGFLAPELG QITYLQELIL
110 120 130 140 150
HGNILIGTIP KEIGNLKNLK ILDLGNNHLM GPIPAEIGSL SGIMIINLQS
160 170 180 190 200
NGLTGKLPAE LGNLKYLREL HIDRNRLQGS LLVAGASGYQ SKVYSSNSSA
210 220 230 240 250
NIAGLCKSLK VADFSYNFFV GNIPKCLENL PRTSFQGNCM QNKDLKHRSS
260 270 280 290 300
SQCANAQLVK THGSPSAAPK HQSAQMVAKH HRASKPKWLL ALEIVTGSMV
310 320 330 340 350
GLLLLVALFS AVHRWNNRST LIIPWKKSSS EKEKFTVYVD SEMLKDVSRL
360 370 380 390 400
TRQELEVACE DFSNIIGLSA DSQIYKGTLK GGSEIAVISL CVKEEDWTGY
410 420 430 440 450
LELYFQREVA DLARLNHENT AKLLGYCKEI SPFTRMLVFE YASNGTLYEH
460 470 480 490 500
LHYGEAALVS WARRMKIVIG IARGLKYLHM ELDPPFTISE LSSNAIYLTE
510 520 530 540 550
DFTPKLVDFE CWKTILARSE KNLRNISSQG SICVLPNGME SRYLDVSGNI
560 570 580 590 600
YAFGILLLEI VSGRPPYCKD KGFLIEWAKE FLEAPEAMSG LVDPELKHFN
610 620 630 640 650
QEDLETVCEV ASQCLNRDPT NNNNNHNKPS VQELCETLES RISLSISAEL
660
RSSSLAWAEL ALDS
Length:664
Mass (Da):73,910
Last modified:May 5, 2009 - v1
Checksum:i8520F165DA7CB366
GO

Sequence cautioni

The sequence AAF19706.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501N → D in BAC42570 (PubMed:11910074).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008047 Genomic DNA. Translation: AAF19706.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34098.1.
AK117932 mRNA. Translation: BAC42570.1.
FJ708668 mRNA. Translation: ACN59263.1.
RefSeqiNP_176532.2. NM_105022.2. [C0LGH8-1]
UniGeneiAt.14999.

Genome annotation databases

EnsemblPlantsiAT1G63430.1; AT1G63430.1; AT1G63430. [C0LGH8-1]
GeneIDi842649.
KEGGiath:AT1G63430.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008047 Genomic DNA. Translation: AAF19706.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34098.1.
AK117932 mRNA. Translation: BAC42570.1.
FJ708668 mRNA. Translation: ACN59263.1.
RefSeqiNP_176532.2. NM_105022.2. [C0LGH8-1]
UniGeneiAt.14999.

3D structure databases

ProteinModelPortaliC0LGH8.
SMRiC0LGH8. Positions 27-230, 345-620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G63430.2.

Proteomic databases

PRIDEiC0LGH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G63430.1; AT1G63430.1; AT1G63430. [C0LGH8-1]
GeneIDi842649.
KEGGiath:AT1G63430.

Organism-specific databases

GeneFarmi693. 50.
TAIRiAT1G63430.

Phylogenomic databases

eggNOGiNOG305556.
HOGENOMiHOG000240929.
InParanoidiC0LGH8.
PhylomeDBiC0LGH8.

Enzyme and pathway databases

BioCyciARA:AT1G63430-MONOMER.
ARA:GQT-2270-MONOMER.

Miscellaneous databases

PROiC0LGH8.

Gene expression databases

ExpressionAtlasiC0LGH8. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiY1634_ARATH
AccessioniPrimary (citable) accession number: C0LGH8
Secondary accession number(s): Q8GY10, Q9SH29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.