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C0LGH8

- Y1634_ARATH

UniProt

C0LGH8 - Y1634_ARATH

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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g63430

Gene
At1g63430, F2K11.19
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G63430-MONOMER.
ARA:GQT-2270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g63430 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g63430
ORF Names:F2K11.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G63430.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 288266Extracellular Reviewed predictionAdd
BLAST
Transmembranei289 – 30921Helical; Reviewed predictionAdd
BLAST
Topological domaini310 – 664355Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 664642Probable LRR receptor-like serine/threonine-protein kinase At1g63430PRO_0000387538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiC0LGH8.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G63430.1-P.

Structurei

3D structure databases

ProteinModelPortaliC0LGH8.
SMRiC0LGH8. Positions 27-230, 345-650.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati94 – 11623LRR 1Add
BLAST
Repeati118 – 14023LRR 2Add
BLAST
Repeati142 – 16524LRR 3Add
BLAST
Repeati166 – 17813LRR 4Add
BLAST
Domaini360 – 642283Protein kinaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305556.
HOGENOMiHOG000240929.
InParanoidiQ8GY10.
PhylomeDBiC0LGH8.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: C0LGH8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRSKYFCSLA LVLGLFFVSC DGFASNEVQA LRRFKEAIYE DPLLVMSNWN    50
DPNSDPCDWT GIYCSPSKDH VIKINISASS IKGFLAPELG QITYLQELIL 100
HGNILIGTIP KEIGNLKNLK ILDLGNNHLM GPIPAEIGSL SGIMIINLQS 150
NGLTGKLPAE LGNLKYLREL HIDRNRLQGS LLVAGASGYQ SKVYSSNSSA 200
NIAGLCKSLK VADFSYNFFV GNIPKCLENL PRTSFQGNCM QNKDLKHRSS 250
SQCANAQLVK THGSPSAAPK HQSAQMVAKH HRASKPKWLL ALEIVTGSMV 300
GLLLLVALFS AVHRWNNRST LIIPWKKSSS EKEKFTVYVD SEMLKDVSRL 350
TRQELEVACE DFSNIIGLSA DSQIYKGTLK GGSEIAVISL CVKEEDWTGY 400
LELYFQREVA DLARLNHENT AKLLGYCKEI SPFTRMLVFE YASNGTLYEH 450
LHYGEAALVS WARRMKIVIG IARGLKYLHM ELDPPFTISE LSSNAIYLTE 500
DFTPKLVDFE CWKTILARSE KNLRNISSQG SICVLPNGME SRYLDVSGNI 550
YAFGILLLEI VSGRPPYCKD KGFLIEWAKE FLEAPEAMSG LVDPELKHFN 600
QEDLETVCEV ASQCLNRDPT NNNNNHNKPS VQELCETLES RISLSISAEL 650
RSSSLAWAEL ALDS 664
Length:664
Mass (Da):73,910
Last modified:May 5, 2009 - v1
Checksum:i8520F165DA7CB366
GO

Sequence cautioni

The sequence AAF19706.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501N → D in BAC42570. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008047 Genomic DNA. Translation: AAF19706.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE34098.1.
AK117932 mRNA. Translation: BAC42570.1.
FJ708668 mRNA. Translation: ACN59263.1.
RefSeqiNP_176532.2. NM_105022.2. [C0LGH8-1]
UniGeneiAt.14999.

Genome annotation databases

EnsemblPlantsiAT1G63430.1; AT1G63430.1; AT1G63430. [C0LGH8-1]
GeneIDi842649.
KEGGiath:AT1G63430.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008047 Genomic DNA. Translation: AAF19706.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE34098.1 .
AK117932 mRNA. Translation: BAC42570.1 .
FJ708668 mRNA. Translation: ACN59263.1 .
RefSeqi NP_176532.2. NM_105022.2. [C0LGH8-1 ]
UniGenei At.14999.

3D structure databases

ProteinModelPortali C0LGH8.
SMRi C0LGH8. Positions 27-230, 345-650.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G63430.1-P.

Proteomic databases

PRIDEi C0LGH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G63430.1 ; AT1G63430.1 ; AT1G63430 . [C0LGH8-1 ]
GeneIDi 842649.
KEGGi ath:AT1G63430.

Organism-specific databases

GeneFarmi 693. 50.
TAIRi AT1G63430.

Phylogenomic databases

eggNOGi NOG305556.
HOGENOMi HOG000240929.
InParanoidi Q8GY10.
PhylomeDBi C0LGH8.

Enzyme and pathway databases

BioCyci ARA:AT1G63430-MONOMER.
ARA:GQT-2270-MONOMER.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiY1634_ARATH
AccessioniPrimary (citable) accession number: C0LGH8
Secondary accession number(s): Q8GY10, Q9SH29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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