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C0LGE4

- Y1124_ARATH

UniProt

C0LGE4 - Y1124_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g12460

Gene

At1g12460

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi599 – 6079ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G12460-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At1g12460 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At1g12460
    ORF Names:F5O11.21, T12C24.1
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G12460.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 882861Probable LRR receptor-like serine/threonine-protein kinase At1g12460PRO_0000387524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Modified residuei589 – 5891PhosphothreonineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiC0LGE4.
    PRIDEiC0LGE4.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGE4.
    SMRiC0LGE4. Positions 26-484, 596-877.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 515494ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini537 – 882346CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei516 – 53621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati92 – 11322LRR 1Add
    BLAST
    Repeati116 – 13823LRR 2Add
    BLAST
    Repeati140 – 16223LRR 3Add
    BLAST
    Repeati165 – 18723LRR 4Add
    BLAST
    Repeati189 – 21022LRR 5Add
    BLAST
    Repeati213 – 23523LRR 6Add
    BLAST
    Repeati237 – 25822LRR 7Add
    BLAST
    Repeati261 – 28323LRR 8Add
    BLAST
    Repeati285 – 30824LRR 9Add
    BLAST
    Repeati309 – 33123LRR 10Add
    BLAST
    Repeati333 – 35523LRR 11Add
    BLAST
    Repeati357 – 37923LRR 12Add
    BLAST
    Repeati381 – 40424LRR 13Add
    BLAST
    Repeati405 – 42723LRR 14Add
    BLAST
    Repeati429 – 45123LRR 15Add
    BLAST
    Repeati453 – 47523LRR 16Add
    BLAST
    Domaini593 – 876284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 16 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116551.
    InParanoidiQ84WP1.
    OMAiPPRICDI.
    PhylomeDBiC0LGE4.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00560. LRR_1. 3 hits.
    PF13855. LRR_8. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C0LGE4-1 [UniParc]FASTAAdd to Basket

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    MRKVHLFLVL VHFIYISTSR SDSISERDIL LQFKGSISDD PYNSLASWVS    50
    DGDLCNSFNG ITCNPQGFVD KIVLWNTSLA GTLAPGLSNL KFIRVLNLFG 100
    NRFTGNLPLD YFKLQTLWTI NVSSNALSGP IPEFISELSS LRFLDLSKNG 150
    FTGEIPVSLF KFCDKTKFVS LAHNNIFGSI PASIVNCNNL VGFDFSYNNL 200
    KGVLPPRICD IPVLEYISVR NNLLSGDVSE EIQKCQRLIL VDLGSNLFHG 250
    LAPFAVLTFK NITYFNVSWN RFGGEIGEIV DCSESLEFLD ASSNELTGRI 300
    PTGVMGCKSL KLLDLESNKL NGSIPGSIGK MESLSVIRLG NNSIDGVIPR 350
    DIGSLEFLQV LNLHNLNLIG EVPEDISNCR VLLELDVSGN DLEGKISKKL 400
    LNLTNIKILD LHRNRLNGSI PPELGNLSKV QFLDLSQNSL SGPIPSSLGS 450
    LNTLTHFNVS YNNLSGVIPP VPMIQAFGSS AFSNNPFLCG DPLVTPCNSR 500
    GAAAKSRNSD ALSISVIIVI IAAAVILFGV CIVLALNLRA RKRRKDEEIL 550
    TVETTPLASS IDSSGVIIGK LVLFSKNLPS KYEDWEAGTK ALLDKENIIG 600
    MGSIGSVYRA SFEGGVSIAV KKLETLGRIR NQEEFEQEIG RLGGLQHPNL 650
    SSFQGYYFSS TMQLILSEFV PNGSLYDNLH LRIFPGTSSS YGNTDLNWHR 700
    RFQIALGTAK ALSFLHNDCK PAILHLNVKS TNILLDERYE AKLSDYGLEK 750
    FLPVMDSFGL TKKFHNAVGY IAPELAQQSL RASEKCDVYS YGVVLLELVT 800
    GRKPVESPSE NQVLILRDYV RDLLETGSAS DCFDRRLREF EENELIQVMK 850
    LGLLCTSENP LKRPSMAEVV QVLESIRNGF GS 882
    Length:882
    Mass (Da):97,022
    Last modified:May 5, 2009 - v1
    Checksum:i228F33D8A05028C4
    GO

    Sequence cautioni

    The sequence AAF79640.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAF88073.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821T → A in AAO22764. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC025416 Genomic DNA. Translation: AAF79640.1. Sequence problems.
    AC025417 Genomic DNA. Translation: AAF88073.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28886.1.
    BT002951 mRNA. Translation: AAO22764.1.
    FJ708633 mRNA. Translation: ACN59229.1.
    AK317750 mRNA. Translation: BAH20406.1.
    RefSeqiNP_172708.1. NM_101118.3.
    UniGeneiAt.42074.
    At.67669.

    Genome annotation databases

    EnsemblPlantsiAT1G12460.1; AT1G12460.1; AT1G12460.
    GeneIDi837803.
    KEGGiath:AT1G12460.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC025416 Genomic DNA. Translation: AAF79640.1 . Sequence problems.
    AC025417 Genomic DNA. Translation: AAF88073.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28886.1 .
    BT002951 mRNA. Translation: AAO22764.1 .
    FJ708633 mRNA. Translation: ACN59229.1 .
    AK317750 mRNA. Translation: BAH20406.1 .
    RefSeqi NP_172708.1. NM_101118.3.
    UniGenei At.42074.
    At.67669.

    3D structure databases

    ProteinModelPortali C0LGE4.
    SMRi C0LGE4. Positions 26-484, 596-877.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi C0LGE4.
    PRIDEi C0LGE4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G12460.1 ; AT1G12460.1 ; AT1G12460 .
    GeneIDi 837803.
    KEGGi ath:AT1G12460.

    Organism-specific databases

    GeneFarmi 2352. 51.
    TAIRi AT1G12460.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116551.
    InParanoidi Q84WP1.
    OMAi PPRICDI.
    PhylomeDBi C0LGE4.

    Enzyme and pathway databases

    BioCyci ARA:AT1G12460-MONOMER.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00560. LRR_1. 3 hits.
    PF13855. LRR_8. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
      Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
      DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-882.
      Strain: cv. Columbia.
      Tissue: Flower and Silique.

    Entry informationi

    Entry nameiY1124_ARATH
    AccessioniPrimary (citable) accession number: C0LGE4
    Secondary accession number(s): B9DI39
    , Q84WP1, Q9LN92, Q9LN98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3