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C0LGE4

- Y1124_ARATH

UniProt

C0LGE4 - Y1124_ARATH

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Protein
Probable LRR receptor-like serine/threonine-protein kinase At1g12460
Gene
At1g12460, F5O11.21, T12C24.1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi599 – 6079ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G12460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g12460 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g12460
ORF Names:F5O11.21, T12C24.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G12460.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 515494Extracellular Reviewed prediction
Add
BLAST
Transmembranei516 – 53621Helical; Reviewed prediction
Add
BLAST
Topological domaini537 – 882346Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 882861Probable LRR receptor-like serine/threonine-protein kinase At1g12460
PRO_0000387524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi463 – 4631N-linked (GlcNAc...) Reviewed prediction
Modified residuei589 – 5891Phosphothreonine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGE4.
PRIDEiC0LGE4.

Structurei

3D structure databases

ProteinModelPortaliC0LGE4.
SMRiC0LGE4. Positions 26-484, 596-877.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 11322LRR 1
Add
BLAST
Repeati116 – 13823LRR 2
Add
BLAST
Repeati140 – 16223LRR 3
Add
BLAST
Repeati165 – 18723LRR 4
Add
BLAST
Repeati189 – 21022LRR 5
Add
BLAST
Repeati213 – 23523LRR 6
Add
BLAST
Repeati237 – 25822LRR 7
Add
BLAST
Repeati261 – 28323LRR 8
Add
BLAST
Repeati285 – 30824LRR 9
Add
BLAST
Repeati309 – 33123LRR 10
Add
BLAST
Repeati333 – 35523LRR 11
Add
BLAST
Repeati357 – 37923LRR 12
Add
BLAST
Repeati381 – 40424LRR 13
Add
BLAST
Repeati405 – 42723LRR 14
Add
BLAST
Repeati429 – 45123LRR 15
Add
BLAST
Repeati453 – 47523LRR 16
Add
BLAST
Domaini593 – 876284Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000116551.
InParanoidiQ84WP1.
OMAiPPRICDI.
PhylomeDBiC0LGE4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGE4-1 [UniParc]FASTAAdd to Basket

« Hide

MRKVHLFLVL VHFIYISTSR SDSISERDIL LQFKGSISDD PYNSLASWVS    50
DGDLCNSFNG ITCNPQGFVD KIVLWNTSLA GTLAPGLSNL KFIRVLNLFG 100
NRFTGNLPLD YFKLQTLWTI NVSSNALSGP IPEFISELSS LRFLDLSKNG 150
FTGEIPVSLF KFCDKTKFVS LAHNNIFGSI PASIVNCNNL VGFDFSYNNL 200
KGVLPPRICD IPVLEYISVR NNLLSGDVSE EIQKCQRLIL VDLGSNLFHG 250
LAPFAVLTFK NITYFNVSWN RFGGEIGEIV DCSESLEFLD ASSNELTGRI 300
PTGVMGCKSL KLLDLESNKL NGSIPGSIGK MESLSVIRLG NNSIDGVIPR 350
DIGSLEFLQV LNLHNLNLIG EVPEDISNCR VLLELDVSGN DLEGKISKKL 400
LNLTNIKILD LHRNRLNGSI PPELGNLSKV QFLDLSQNSL SGPIPSSLGS 450
LNTLTHFNVS YNNLSGVIPP VPMIQAFGSS AFSNNPFLCG DPLVTPCNSR 500
GAAAKSRNSD ALSISVIIVI IAAAVILFGV CIVLALNLRA RKRRKDEEIL 550
TVETTPLASS IDSSGVIIGK LVLFSKNLPS KYEDWEAGTK ALLDKENIIG 600
MGSIGSVYRA SFEGGVSIAV KKLETLGRIR NQEEFEQEIG RLGGLQHPNL 650
SSFQGYYFSS TMQLILSEFV PNGSLYDNLH LRIFPGTSSS YGNTDLNWHR 700
RFQIALGTAK ALSFLHNDCK PAILHLNVKS TNILLDERYE AKLSDYGLEK 750
FLPVMDSFGL TKKFHNAVGY IAPELAQQSL RASEKCDVYS YGVVLLELVT 800
GRKPVESPSE NQVLILRDYV RDLLETGSAS DCFDRRLREF EENELIQVMK 850
LGLLCTSENP LKRPSMAEVV QVLESIRNGF GS 882
Length:882
Mass (Da):97,022
Last modified:May 5, 2009 - v1
Checksum:i228F33D8A05028C4
GO

Sequence cautioni

The sequence AAF79640.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AAF88073.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821T → A in AAO22764. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC025416 Genomic DNA. Translation: AAF79640.1. Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1.
BT002951 mRNA. Translation: AAO22764.1.
FJ708633 mRNA. Translation: ACN59229.1.
AK317750 mRNA. Translation: BAH20406.1.
RefSeqiNP_172708.1. NM_101118.3.
UniGeneiAt.42074.
At.67669.

Genome annotation databases

EnsemblPlantsiAT1G12460.1; AT1G12460.1; AT1G12460.
GeneIDi837803.
KEGGiath:AT1G12460.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC025416 Genomic DNA. Translation: AAF79640.1 . Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1 .
BT002951 mRNA. Translation: AAO22764.1 .
FJ708633 mRNA. Translation: ACN59229.1 .
AK317750 mRNA. Translation: BAH20406.1 .
RefSeqi NP_172708.1. NM_101118.3.
UniGenei At.42074.
At.67669.

3D structure databases

ProteinModelPortali C0LGE4.
SMRi C0LGE4. Positions 26-484, 596-877.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi C0LGE4.
PRIDEi C0LGE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G12460.1 ; AT1G12460.1 ; AT1G12460 .
GeneIDi 837803.
KEGGi ath:AT1G12460.

Organism-specific databases

GeneFarmi 2352. 51.
TAIRi AT1G12460.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000116551.
InParanoidi Q84WP1.
OMAi PPRICDI.
PhylomeDBi C0LGE4.

Enzyme and pathway databases

BioCyci ARA:AT1G12460-MONOMER.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-882.
    Strain: cv. Columbia.
    Tissue: Flower and Silique.

Entry informationi

Entry nameiY1124_ARATH
AccessioniPrimary (citable) accession number: C0LGE4
Secondary accession number(s): B9DI39
, Q84WP1, Q9LN92, Q9LN98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi