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C0LGE4

- Y1124_ARATH

UniProt

C0LGE4 - Y1124_ARATH

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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g12460

Gene

At1g12460

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi599 – 6079ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G12460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g12460 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g12460
ORF Names:F5O11.21, T12C24.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G12460.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 515494ExtracellularSequence AnalysisAdd
BLAST
Transmembranei516 – 53621HelicalSequence AnalysisAdd
BLAST
Topological domaini537 – 882346CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 882861Probable LRR receptor-like serine/threonine-protein kinase At1g12460PRO_0000387524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Modified residuei589 – 5891PhosphothreonineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGE4.
PRIDEiC0LGE4.

Structurei

3D structure databases

ProteinModelPortaliC0LGE4.
SMRiC0LGE4. Positions 26-499, 596-877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 11322LRR 1Add
BLAST
Repeati116 – 13823LRR 2Add
BLAST
Repeati140 – 16223LRR 3Add
BLAST
Repeati165 – 18723LRR 4Add
BLAST
Repeati189 – 21022LRR 5Add
BLAST
Repeati213 – 23523LRR 6Add
BLAST
Repeati237 – 25822LRR 7Add
BLAST
Repeati261 – 28323LRR 8Add
BLAST
Repeati285 – 30824LRR 9Add
BLAST
Repeati309 – 33123LRR 10Add
BLAST
Repeati333 – 35523LRR 11Add
BLAST
Repeati357 – 37923LRR 12Add
BLAST
Repeati381 – 40424LRR 13Add
BLAST
Repeati405 – 42723LRR 14Add
BLAST
Repeati429 – 45123LRR 15Add
BLAST
Repeati453 – 47523LRR 16Add
BLAST
Domaini593 – 876284Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000116551.
InParanoidiC0LGE4.
OMAiPPRICDI.
PhylomeDBiC0LGE4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKVHLFLVL VHFIYISTSR SDSISERDIL LQFKGSISDD PYNSLASWVS
60 70 80 90 100
DGDLCNSFNG ITCNPQGFVD KIVLWNTSLA GTLAPGLSNL KFIRVLNLFG
110 120 130 140 150
NRFTGNLPLD YFKLQTLWTI NVSSNALSGP IPEFISELSS LRFLDLSKNG
160 170 180 190 200
FTGEIPVSLF KFCDKTKFVS LAHNNIFGSI PASIVNCNNL VGFDFSYNNL
210 220 230 240 250
KGVLPPRICD IPVLEYISVR NNLLSGDVSE EIQKCQRLIL VDLGSNLFHG
260 270 280 290 300
LAPFAVLTFK NITYFNVSWN RFGGEIGEIV DCSESLEFLD ASSNELTGRI
310 320 330 340 350
PTGVMGCKSL KLLDLESNKL NGSIPGSIGK MESLSVIRLG NNSIDGVIPR
360 370 380 390 400
DIGSLEFLQV LNLHNLNLIG EVPEDISNCR VLLELDVSGN DLEGKISKKL
410 420 430 440 450
LNLTNIKILD LHRNRLNGSI PPELGNLSKV QFLDLSQNSL SGPIPSSLGS
460 470 480 490 500
LNTLTHFNVS YNNLSGVIPP VPMIQAFGSS AFSNNPFLCG DPLVTPCNSR
510 520 530 540 550
GAAAKSRNSD ALSISVIIVI IAAAVILFGV CIVLALNLRA RKRRKDEEIL
560 570 580 590 600
TVETTPLASS IDSSGVIIGK LVLFSKNLPS KYEDWEAGTK ALLDKENIIG
610 620 630 640 650
MGSIGSVYRA SFEGGVSIAV KKLETLGRIR NQEEFEQEIG RLGGLQHPNL
660 670 680 690 700
SSFQGYYFSS TMQLILSEFV PNGSLYDNLH LRIFPGTSSS YGNTDLNWHR
710 720 730 740 750
RFQIALGTAK ALSFLHNDCK PAILHLNVKS TNILLDERYE AKLSDYGLEK
760 770 780 790 800
FLPVMDSFGL TKKFHNAVGY IAPELAQQSL RASEKCDVYS YGVVLLELVT
810 820 830 840 850
GRKPVESPSE NQVLILRDYV RDLLETGSAS DCFDRRLREF EENELIQVMK
860 870 880
LGLLCTSENP LKRPSMAEVV QVLESIRNGF GS
Length:882
Mass (Da):97,022
Last modified:May 5, 2009 - v1
Checksum:i228F33D8A05028C4
GO

Sequence cautioni

The sequence AAF79640.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAF88073.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821T → A in AAO22764. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025416 Genomic DNA. Translation: AAF79640.1. Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1.
BT002951 mRNA. Translation: AAO22764.1.
FJ708633 mRNA. Translation: ACN59229.1.
AK317750 mRNA. Translation: BAH20406.1.
RefSeqiNP_172708.1. NM_101118.3.
UniGeneiAt.42074.
At.67669.

Genome annotation databases

EnsemblPlantsiAT1G12460.1; AT1G12460.1; AT1G12460.
GeneIDi837803.
KEGGiath:AT1G12460.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025416 Genomic DNA. Translation: AAF79640.1 . Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1 .
BT002951 mRNA. Translation: AAO22764.1 .
FJ708633 mRNA. Translation: ACN59229.1 .
AK317750 mRNA. Translation: BAH20406.1 .
RefSeqi NP_172708.1. NM_101118.3.
UniGenei At.42074.
At.67669.

3D structure databases

ProteinModelPortali C0LGE4.
SMRi C0LGE4. Positions 26-499, 596-877.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi C0LGE4.
PRIDEi C0LGE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G12460.1 ; AT1G12460.1 ; AT1G12460 .
GeneIDi 837803.
KEGGi ath:AT1G12460.

Organism-specific databases

GeneFarmi 2352. 51.
TAIRi AT1G12460.

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000116551.
InParanoidi C0LGE4.
OMAi PPRICDI.
PhylomeDBi C0LGE4.

Enzyme and pathway databases

BioCyci ARA:AT1G12460-MONOMER.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-882.
    Strain: cv. Columbia.
    Tissue: Flower and Silique.

Entry informationi

Entry nameiY1124_ARATH
AccessioniPrimary (citable) accession number: C0LGE4
Secondary accession number(s): B9DI39
, Q84WP1, Q9LN92, Q9LN98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3