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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g12460

Gene

At1g12460

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei621ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi599 – 607ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g12460 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g12460
ORF Names:F5O11.21, T12C24.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G12460.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 515ExtracellularSequence analysisAdd BLAST494
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 882CytoplasmicSequence analysisAdd BLAST346

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038752422 – 882Probable LRR receptor-like serine/threonine-protein kinase At1g12460Add BLAST861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Modified residuei589PhosphothreonineBy similarity1
Modified residuei770PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGE4.
PRIDEiC0LGE4.

PTM databases

iPTMnetiC0LGE4.

Expressioni

Gene expression databases

GenevisibleiC0LGE4. AT.

Interactioni

Protein-protein interaction databases

BioGridi23043. 1 interactor.
STRINGi3702.AT1G12460.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGE4.
SMRiC0LGE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 138LRR 2Add BLAST23
Repeati140 – 162LRR 3Add BLAST23
Repeati165 – 187LRR 4Add BLAST23
Repeati189 – 210LRR 5Add BLAST22
Repeati213 – 235LRR 6Add BLAST23
Repeati237 – 258LRR 7Add BLAST22
Repeati261 – 283LRR 8Add BLAST23
Repeati285 – 308LRR 9Add BLAST24
Repeati309 – 331LRR 10Add BLAST23
Repeati333 – 355LRR 11Add BLAST23
Repeati357 – 379LRR 12Add BLAST23
Repeati381 – 404LRR 13Add BLAST24
Repeati405 – 427LRR 14Add BLAST23
Repeati429 – 451LRR 15Add BLAST23
Repeati453 – 475LRR 16Add BLAST23
Domaini593 – 876Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHDY. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiC0LGE4.
OMAiDQLCAPP.
OrthoDBiEOG093601U1.
PhylomeDBiC0LGE4.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVHLFLVL VHFIYISTSR SDSISERDIL LQFKGSISDD PYNSLASWVS
60 70 80 90 100
DGDLCNSFNG ITCNPQGFVD KIVLWNTSLA GTLAPGLSNL KFIRVLNLFG
110 120 130 140 150
NRFTGNLPLD YFKLQTLWTI NVSSNALSGP IPEFISELSS LRFLDLSKNG
160 170 180 190 200
FTGEIPVSLF KFCDKTKFVS LAHNNIFGSI PASIVNCNNL VGFDFSYNNL
210 220 230 240 250
KGVLPPRICD IPVLEYISVR NNLLSGDVSE EIQKCQRLIL VDLGSNLFHG
260 270 280 290 300
LAPFAVLTFK NITYFNVSWN RFGGEIGEIV DCSESLEFLD ASSNELTGRI
310 320 330 340 350
PTGVMGCKSL KLLDLESNKL NGSIPGSIGK MESLSVIRLG NNSIDGVIPR
360 370 380 390 400
DIGSLEFLQV LNLHNLNLIG EVPEDISNCR VLLELDVSGN DLEGKISKKL
410 420 430 440 450
LNLTNIKILD LHRNRLNGSI PPELGNLSKV QFLDLSQNSL SGPIPSSLGS
460 470 480 490 500
LNTLTHFNVS YNNLSGVIPP VPMIQAFGSS AFSNNPFLCG DPLVTPCNSR
510 520 530 540 550
GAAAKSRNSD ALSISVIIVI IAAAVILFGV CIVLALNLRA RKRRKDEEIL
560 570 580 590 600
TVETTPLASS IDSSGVIIGK LVLFSKNLPS KYEDWEAGTK ALLDKENIIG
610 620 630 640 650
MGSIGSVYRA SFEGGVSIAV KKLETLGRIR NQEEFEQEIG RLGGLQHPNL
660 670 680 690 700
SSFQGYYFSS TMQLILSEFV PNGSLYDNLH LRIFPGTSSS YGNTDLNWHR
710 720 730 740 750
RFQIALGTAK ALSFLHNDCK PAILHLNVKS TNILLDERYE AKLSDYGLEK
760 770 780 790 800
FLPVMDSFGL TKKFHNAVGY IAPELAQQSL RASEKCDVYS YGVVLLELVT
810 820 830 840 850
GRKPVESPSE NQVLILRDYV RDLLETGSAS DCFDRRLREF EENELIQVMK
860 870 880
LGLLCTSENP LKRPSMAEVV QVLESIRNGF GS
Length:882
Mass (Da):97,022
Last modified:May 5, 2009 - v1
Checksum:i228F33D8A05028C4
GO

Sequence cautioni

The sequence AAF79640 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF88073 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82T → A in AAO22764 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025416 Genomic DNA. Translation: AAF79640.1. Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1.
BT002951 mRNA. Translation: AAO22764.1.
FJ708633 mRNA. Translation: ACN59229.1.
AK317750 mRNA. Translation: BAH20406.1.
RefSeqiNP_172708.1. NM_101118.4.
UniGeneiAt.42074.
At.67669.

Genome annotation databases

EnsemblPlantsiAT1G12460.1; AT1G12460.1; AT1G12460.
GeneIDi837803.
GrameneiAT1G12460.1; AT1G12460.1; AT1G12460.
KEGGiath:AT1G12460.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025416 Genomic DNA. Translation: AAF79640.1. Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1.
BT002951 mRNA. Translation: AAO22764.1.
FJ708633 mRNA. Translation: ACN59229.1.
AK317750 mRNA. Translation: BAH20406.1.
RefSeqiNP_172708.1. NM_101118.4.
UniGeneiAt.42074.
At.67669.

3D structure databases

ProteinModelPortaliC0LGE4.
SMRiC0LGE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23043. 1 interactor.
STRINGi3702.AT1G12460.1.

PTM databases

iPTMnetiC0LGE4.

Proteomic databases

PaxDbiC0LGE4.
PRIDEiC0LGE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G12460.1; AT1G12460.1; AT1G12460.
GeneIDi837803.
GrameneiAT1G12460.1; AT1G12460.1; AT1G12460.
KEGGiath:AT1G12460.

Organism-specific databases

TAIRiAT1G12460.

Phylogenomic databases

eggNOGiENOG410IHDY. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiC0LGE4.
OMAiDQLCAPP.
OrthoDBiEOG093601U1.
PhylomeDBiC0LGE4.

Miscellaneous databases

PROiC0LGE4.

Gene expression databases

GenevisibleiC0LGE4. AT.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY1124_ARATH
AccessioniPrimary (citable) accession number: C0LGE4
Secondary accession number(s): B9DI39
, Q84WP1, Q9LN92, Q9LN98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.