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C0LGE4 (Y1124_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g12460

EC=2.7.11.1
Gene names
Ordered Locus Names:At1g12460
ORF Names:F5O11.21, T12C24.1
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length882 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 16 LRR (leucine-rich) repeats.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAF79640.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAF88073.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 882861Probable LRR receptor-like serine/threonine-protein kinase At1g12460
PRO_0000387524

Regions

Topological domain22 – 515494Extracellular Potential
Transmembrane516 – 53621Helical; Potential
Topological domain537 – 882346Cytoplasmic Potential
Repeat92 – 11322LRR 1
Repeat116 – 13823LRR 2
Repeat140 – 16223LRR 3
Repeat165 – 18723LRR 4
Repeat189 – 21022LRR 5
Repeat213 – 23523LRR 6
Repeat237 – 25822LRR 7
Repeat261 – 28323LRR 8
Repeat285 – 30824LRR 9
Repeat309 – 33123LRR 10
Repeat333 – 35523LRR 11
Repeat357 – 37923LRR 12
Repeat381 – 40424LRR 13
Repeat405 – 42723LRR 14
Repeat429 – 45123LRR 15
Repeat453 – 47523LRR 16
Domain593 – 876284Protein kinase
Nucleotide binding599 – 6079ATP By similarity

Sites

Binding site6211ATP By similarity

Amino acid modifications

Modified residue5891Phosphothreonine By similarity
Glycosylation761N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3411N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential
Glycosylation4581N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict821T → A in AAO22764. Ref.3

Sequences

Sequence LengthMass (Da)Tools
C0LGE4 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 228F33D8A05028C4

FASTA88297,022
        10         20         30         40         50         60 
MRKVHLFLVL VHFIYISTSR SDSISERDIL LQFKGSISDD PYNSLASWVS DGDLCNSFNG 

        70         80         90        100        110        120 
ITCNPQGFVD KIVLWNTSLA GTLAPGLSNL KFIRVLNLFG NRFTGNLPLD YFKLQTLWTI 

       130        140        150        160        170        180 
NVSSNALSGP IPEFISELSS LRFLDLSKNG FTGEIPVSLF KFCDKTKFVS LAHNNIFGSI 

       190        200        210        220        230        240 
PASIVNCNNL VGFDFSYNNL KGVLPPRICD IPVLEYISVR NNLLSGDVSE EIQKCQRLIL 

       250        260        270        280        290        300 
VDLGSNLFHG LAPFAVLTFK NITYFNVSWN RFGGEIGEIV DCSESLEFLD ASSNELTGRI 

       310        320        330        340        350        360 
PTGVMGCKSL KLLDLESNKL NGSIPGSIGK MESLSVIRLG NNSIDGVIPR DIGSLEFLQV 

       370        380        390        400        410        420 
LNLHNLNLIG EVPEDISNCR VLLELDVSGN DLEGKISKKL LNLTNIKILD LHRNRLNGSI 

       430        440        450        460        470        480 
PPELGNLSKV QFLDLSQNSL SGPIPSSLGS LNTLTHFNVS YNNLSGVIPP VPMIQAFGSS 

       490        500        510        520        530        540 
AFSNNPFLCG DPLVTPCNSR GAAAKSRNSD ALSISVIIVI IAAAVILFGV CIVLALNLRA 

       550        560        570        580        590        600 
RKRRKDEEIL TVETTPLASS IDSSGVIIGK LVLFSKNLPS KYEDWEAGTK ALLDKENIIG 

       610        620        630        640        650        660 
MGSIGSVYRA SFEGGVSIAV KKLETLGRIR NQEEFEQEIG RLGGLQHPNL SSFQGYYFSS 

       670        680        690        700        710        720 
TMQLILSEFV PNGSLYDNLH LRIFPGTSSS YGNTDLNWHR RFQIALGTAK ALSFLHNDCK 

       730        740        750        760        770        780 
PAILHLNVKS TNILLDERYE AKLSDYGLEK FLPVMDSFGL TKKFHNAVGY IAPELAQQSL 

       790        800        810        820        830        840 
RASEKCDVYS YGVVLLELVT GRKPVESPSE NQVLILRDYV RDLLETGSAS DCFDRRLREF 

       850        860        870        880 
EENELIQVMK LGLLCTSENP LKRPSMAEVV QVLESIRNGF GS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-882.
Strain: cv. Columbia.
Tissue: Flower and Silique.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC025416 Genomic DNA. Translation: AAF79640.1. Sequence problems.
AC025417 Genomic DNA. Translation: AAF88073.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28886.1.
BT002951 mRNA. Translation: AAO22764.1.
FJ708633 mRNA. Translation: ACN59229.1.
AK317750 mRNA. Translation: BAH20406.1.
RefSeqNP_172708.1. NM_101118.3.
UniGeneAt.42074.
At.67669.

3D structure databases

ProteinModelPortalC0LGE4.
SMRC0LGE4. Positions 25-497, 596-874.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbC0LGE4.
PRIDEC0LGE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G12460.1; AT1G12460.1; AT1G12460.
GeneID837803.
KEGGath:AT1G12460.

Organism-specific databases

GeneFarm2352. 51.
TAIRAT1G12460.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000116551.
InParanoidQ84WP1.
OMAPPRICDI.
PhylomeDBC0LGE4.
ProtClustDBCLSN2682269.

Enzyme and pathway databases

BioCycARA:AT1G12460-MONOMER.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF00560. LRR_1. 3 hits.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY1124_ARATH
AccessionPrimary (citable) accession number: C0LGE4
Secondary accession number(s): B9DI39 expand/collapse secondary AC list , Q84WP1, Q9LN92, Q9LN98
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names