ID   Y1684_ARATH             Reviewed;         953 AA.
AC   C0LGD7; Q9M9Z0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   24-JAN-2024, entry version 102.
DE   RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g06840;
DE            EC=2.7.11.1;
DE   Flags: Precursor;
GN   OrderedLocusNames=At1g06840; ORFNames=F4H5.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA   Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT   "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT   like protein kinase genes in Arabidopsis thaliana.";
RL   BMC Genomics 11:19-19(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- INTERACTION:
CC       C0LGD7-2; Q9M9C5: At1g68400; NbExp=2; IntAct=EBI-20651159, EBI-1238661;
CC       C0LGD7-2; Q9LFS4: NIK1; NbExp=2; IntAct=EBI-20651159, EBI-16146189;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC       membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=C0LGD7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=C0LGD7-2; Sequence=VSP_038290, VSP_038291;
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF63151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC011001; AAF63151.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28044.1; -; Genomic_DNA.
DR   EMBL; FJ708626; ACN59222.1; -; mRNA.
DR   PIR; C86203; C86203.
DR   RefSeq; NP_172169.2; NM_100561.4. [C0LGD7-1]
DR   AlphaFoldDB; C0LGD7; -.
DR   SMR; C0LGD7; -.
DR   BioGRID; 22437; 30.
DR   IntAct; C0LGD7; 30.
DR   STRING; 3702.C0LGD7; -.
DR   iPTMnet; C0LGD7; -.
DR   PaxDb; 3702-AT1G06840-1; -.
DR   ProteomicsDB; 228721; -. [C0LGD7-1]
DR   EnsemblPlants; AT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
DR   GeneID; 837196; -.
DR   Gramene; AT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
DR   KEGG; ath:AT1G06840; -.
DR   Araport; AT1G06840; -.
DR   TAIR; AT1G06840; -.
DR   eggNOG; ENOG502QS0B; Eukaryota.
DR   HOGENOM; CLU_000288_14_3_1; -.
DR   InParanoid; C0LGD7; -.
DR   OMA; CPFPYEY; -.
DR   OrthoDB; 1214803at2759; -.
DR   PhylomeDB; C0LGD7; -.
DR   PRO; PR:C0LGD7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; C0LGD7; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd21699; JMTM_APP_like; 1.
DR   CDD; cd14066; STKc_IRAK; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR013210; LRR_N_plant-typ.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR45974:SF134; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45974; RECEPTOR-LIKE PROTEIN 55; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF08263; LRRNT_2; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   Genevisible; C0LGD7; AT.
PE   1: Evidence at protein level;
KW   Alternative splicing; ATP-binding; Glycoprotein; Kinase;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Receptor;
KW   Reference proteome; Repeat; Serine/threonine-protein kinase; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..953
FT                   /note="Probable LRR receptor-like serine/threonine-protein
FT                   kinase At1g06840"
FT                   /id="PRO_0000387540"
FT   TOPO_DOM        29..563
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        564..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        585..953
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          85..106
FT                   /note="LRR 1"
FT   REPEAT          107..130
FT                   /note="LRR 2"
FT   REPEAT          132..155
FT                   /note="LRR 3"
FT   REPEAT          156..177
FT                   /note="LRR 4"
FT   REPEAT          180..203
FT                   /note="LRR 5"
FT   REPEAT          204..226
FT                   /note="LRR 6"
FT   REPEAT          228..251
FT                   /note="LRR 7"
FT   REPEAT          253..275
FT                   /note="LRR 8"
FT   REPEAT          276..298
FT                   /note="LRR 9"
FT   REPEAT          299..322
FT                   /note="LRR 10"
FT   REPEAT          323..345
FT                   /note="LRR 11"
FT   REPEAT          352..373
FT                   /note="LRR 12"
FT   REPEAT          374..395
FT                   /note="LRR 13"
FT   DOMAIN          625..897
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REPEAT          845..868
FT                   /note="LRR 14"
FT   ACT_SITE        749
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         631..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        214
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        250
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        288
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        307
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        317
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        349
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        365
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        411
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        502
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        508
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        537
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         695..700
FT                   /note="MLVYEY -> RADAGL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:20064227"
FT                   /id="VSP_038290"
FT   VAR_SEQ         701..953
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:20064227"
FT                   /id="VSP_038291"
SQ   SEQUENCE   953 AA;  105625 MW;  C2EF7F0F4100FDCC CRC64;
     MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND PVHRLRNWKH
     GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS PELGRLSRLT ILSFMWNKIT
     GSIPKEIGNI KSLELLLLNG NLLNGNLPEE LGFLPNLDRI QIDENRISGP LPKSFANLNK
     TKHFHMNNNS ISGQIPPELG SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD
     GTTIPQSYGN MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI
     TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS TESIIVDLRN
     NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE EDINQGSTNS NTTICSDCPP
     PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ
     WQKGPRLRMY LKFFPVFGSN ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL
     LDVYRDVFPS ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS
     SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV AIKRAQEGSL
     QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY MENGTLRDNI SVKLKEPLDF
     AMRLRIALGS AKGILYLHTE ANPPIFHRDI KASNILLDSR FTAKVADFGL SRLAPVPDME
     GISPQHVSTV VKGTPGYLDP EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE
     INIAYESGSI LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL
     MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV APR
//