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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g06840

Gene

At1g06840

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPPROSITE-ProRule annotation1
Active sitei749Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi631 – 639ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g06840 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g06840
ORF Names:F4H5.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G06840.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 563ExtracellularSequence analysisAdd BLAST535
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 953CytoplasmicSequence analysisAdd BLAST369

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000038754029 – 953Probable LRR receptor-like serine/threonine-protein kinase At1g06840Add BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi411N-linked (GlcNAc...)Sequence analysis1
Glycosylationi502N-linked (GlcNAc...)Sequence analysis1
Glycosylationi508N-linked (GlcNAc...)Sequence analysis1
Glycosylationi537N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiC0LGD7.

PTM databases

iPTMnetiC0LGD7.

Expressioni

Gene expression databases

GenevisibleiC0LGD7. AT.

Interactioni

Protein-protein interaction databases

BioGridi22437. 1 interactor.
STRINGi3702.AT1G06840.1.

Structurei

3D structure databases

ProteinModelPortaliC0LGD7.
SMRiC0LGD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 106LRR 1Add BLAST22
Repeati107 – 130LRR 2Add BLAST24
Repeati132 – 155LRR 3Add BLAST24
Repeati156 – 177LRR 4Add BLAST22
Repeati180 – 203LRR 5Add BLAST24
Repeati204 – 226LRR 6Add BLAST23
Repeati228 – 251LRR 7Add BLAST24
Repeati253 – 275LRR 8Add BLAST23
Repeati276 – 298LRR 9Add BLAST23
Repeati299 – 322LRR 10Add BLAST24
Repeati323 – 345LRR 11Add BLAST23
Repeati352 – 373LRR 12Add BLAST22
Repeati374 – 395LRR 13Add BLAST22
Domaini625 – 897Protein kinasePROSITE-ProRule annotationAdd BLAST273
Repeati845 – 868LRR 14Add BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 14 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPD. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116556.
InParanoidiC0LGD7.
OMAiWELMPES.
OrthoDBiEOG093601AR.
PhylomeDBiC0LGD7.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: C0LGD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND
60 70 80 90 100
PVHRLRNWKH GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS
110 120 130 140 150
PELGRLSRLT ILSFMWNKIT GSIPKEIGNI KSLELLLLNG NLLNGNLPEE
160 170 180 190 200
LGFLPNLDRI QIDENRISGP LPKSFANLNK TKHFHMNNNS ISGQIPPELG
210 220 230 240 250
SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD GTTIPQSYGN
260 270 280 290 300
MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI
310 320 330 340 350
TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS
360 370 380 390 400
TESIIVDLRN NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE
410 420 430 440 450
EDINQGSTNS NTTICSDCPP PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS
460 470 480 490 500
DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ WQKGPRLRMY LKFFPVFGSN
510 520 530 540 550
ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL LDVYRDVFPS
560 570 580 590 600
ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS
610 620 630 640 650
SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV
660 670 680 690 700
AIKRAQEGSL QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY
710 720 730 740 750
MENGTLRDNI SVKLKEPLDF AMRLRIALGS AKGILYLHTE ANPPIFHRDI
760 770 780 790 800
KASNILLDSR FTAKVADFGL SRLAPVPDME GISPQHVSTV VKGTPGYLDP
810 820 830 840 850
EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE INIAYESGSI
860 870 880 890 900
LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL
910 920 930 940 950
MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV

APR
Note: Derived from EST data. No experimental confirmation available.
Length:953
Mass (Da):105,625
Last modified:November 3, 2009 - v2
Checksum:iC2EF7F0F4100FDCC
GO
Isoform 2 (identifier: C0LGD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     695-700: MLVYEY → RADAGL
     701-953: Missing.

Show »
Length:700
Mass (Da):77,571
Checksum:iEF4AB3DE4381885A
GO

Sequence cautioni

The sequence AAF63151 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038290695 – 700MLVYEY → RADAGL in isoform 2. 1 Publication6
Alternative sequenceiVSP_038291701 – 953Missing in isoform 2. 1 PublicationAdd BLAST253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA. Translation: AAF63151.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1.
FJ708626 mRNA. Translation: ACN59222.1.
PIRiC86203.
RefSeqiNP_172169.2. NM_100561.4. [C0LGD7-1]
UniGeneiAt.42324.

Genome annotation databases

EnsemblPlantsiAT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
GeneIDi837196.
GrameneiAT1G06840.1; AT1G06840.1; AT1G06840.
KEGGiath:AT1G06840.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA. Translation: AAF63151.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1.
FJ708626 mRNA. Translation: ACN59222.1.
PIRiC86203.
RefSeqiNP_172169.2. NM_100561.4. [C0LGD7-1]
UniGeneiAt.42324.

3D structure databases

ProteinModelPortaliC0LGD7.
SMRiC0LGD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22437. 1 interactor.
STRINGi3702.AT1G06840.1.

PTM databases

iPTMnetiC0LGD7.

Proteomic databases

PaxDbiC0LGD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
GeneIDi837196.
GrameneiAT1G06840.1; AT1G06840.1; AT1G06840.
KEGGiath:AT1G06840.

Organism-specific databases

TAIRiAT1G06840.

Phylogenomic databases

eggNOGiENOG410IFPD. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116556.
InParanoidiC0LGD7.
OMAiWELMPES.
OrthoDBiEOG093601AR.
PhylomeDBiC0LGD7.

Miscellaneous databases

PROiC0LGD7.

Gene expression databases

GenevisibleiC0LGD7. AT.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY1684_ARATH
AccessioniPrimary (citable) accession number: C0LGD7
Secondary accession number(s): Q9M9Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 30, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.