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C0LGD7

- Y1684_ARATH

UniProt

C0LGD7 - Y1684_ARATH

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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g06840

Gene

At1g06840

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATPPROSITE-ProRule annotation
Active sitei749 – 7491Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi631 – 6399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G06840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g06840 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g06840
ORF Names:F4H5.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G06840.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 563535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei564 – 58421HelicalSequence AnalysisAdd
BLAST
Topological domaini585 – 953369CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 953925Probable LRR receptor-like serine/threonine-protein kinase At1g06840PRO_0000387540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi411 – 4111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiC0LGD7.
PRIDEiC0LGD7.

Interactioni

Protein-protein interaction databases

BioGridi22437. 1 interaction.
STRINGi3702.AT1G06840.1-P.

Structurei

3D structure databases

ProteinModelPortaliC0LGD7.
SMRiC0LGD7. Positions 36-399, 571-905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati85 – 10622LRR 1Add
BLAST
Repeati107 – 13024LRR 2Add
BLAST
Repeati132 – 15524LRR 3Add
BLAST
Repeati156 – 17722LRR 4Add
BLAST
Repeati180 – 20324LRR 5Add
BLAST
Repeati204 – 22623LRR 6Add
BLAST
Repeati228 – 25124LRR 7Add
BLAST
Repeati253 – 27523LRR 8Add
BLAST
Repeati276 – 29823LRR 9Add
BLAST
Repeati299 – 32224LRR 10Add
BLAST
Repeati323 – 34523LRR 11Add
BLAST
Repeati352 – 37322LRR 12Add
BLAST
Repeati374 – 39522LRR 13Add
BLAST
Domaini625 – 897273Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati845 – 86824LRR 14Add
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 14 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116556.
InParanoidiC0LGD7.
OMAiFMWNKIT.
PhylomeDBiC0LGD7.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: C0LGD7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND
60 70 80 90 100
PVHRLRNWKH GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS
110 120 130 140 150
PELGRLSRLT ILSFMWNKIT GSIPKEIGNI KSLELLLLNG NLLNGNLPEE
160 170 180 190 200
LGFLPNLDRI QIDENRISGP LPKSFANLNK TKHFHMNNNS ISGQIPPELG
210 220 230 240 250
SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD GTTIPQSYGN
260 270 280 290 300
MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI
310 320 330 340 350
TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS
360 370 380 390 400
TESIIVDLRN NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE
410 420 430 440 450
EDINQGSTNS NTTICSDCPP PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS
460 470 480 490 500
DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ WQKGPRLRMY LKFFPVFGSN
510 520 530 540 550
ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL LDVYRDVFPS
560 570 580 590 600
ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS
610 620 630 640 650
SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV
660 670 680 690 700
AIKRAQEGSL QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY
710 720 730 740 750
MENGTLRDNI SVKLKEPLDF AMRLRIALGS AKGILYLHTE ANPPIFHRDI
760 770 780 790 800
KASNILLDSR FTAKVADFGL SRLAPVPDME GISPQHVSTV VKGTPGYLDP
810 820 830 840 850
EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE INIAYESGSI
860 870 880 890 900
LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL
910 920 930 940 950
MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV

APR

Note: Derived from EST data. No experimental confirmation available.

Length:953
Mass (Da):105,625
Last modified:November 3, 2009 - v2
Checksum:iC2EF7F0F4100FDCC
GO
Isoform 2 (identifier: C0LGD7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     695-700: MLVYEY → RADAGL
     701-953: Missing.

Show »
Length:700
Mass (Da):77,571
Checksum:iEF4AB3DE4381885A
GO

Sequence cautioni

The sequence AAF63151.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei695 – 7006MLVYEY → RADAGL in isoform 2. 1 PublicationVSP_038290
Alternative sequencei701 – 953253Missing in isoform 2. 1 PublicationVSP_038291Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA. Translation: AAF63151.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1.
FJ708626 mRNA. Translation: ACN59222.1.
PIRiC86203.
RefSeqiNP_172169.2. NM_100561.3. [C0LGD7-1]
UniGeneiAt.42324.

Genome annotation databases

EnsemblPlantsiAT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
GeneIDi837196.
KEGGiath:AT1G06840.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA. Translation: AAF63151.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1 .
FJ708626 mRNA. Translation: ACN59222.1 .
PIRi C86203.
RefSeqi NP_172169.2. NM_100561.3. [C0LGD7-1 ]
UniGenei At.42324.

3D structure databases

ProteinModelPortali C0LGD7.
SMRi C0LGD7. Positions 36-399, 571-905.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 22437. 1 interaction.
STRINGi 3702.AT1G06840.1-P.

Proteomic databases

PaxDbi C0LGD7.
PRIDEi C0LGD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G06840.1 ; AT1G06840.1 ; AT1G06840 . [C0LGD7-1 ]
GeneIDi 837196.
KEGGi ath:AT1G06840.

Organism-specific databases

GeneFarmi 2390. 52.
TAIRi AT1G06840.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000116556.
InParanoidi C0LGD7.
OMAi FMWNKIT.
PhylomeDBi C0LGD7.

Enzyme and pathway databases

BioCyci ARA:AT1G06840-MONOMER.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiY1684_ARATH
AccessioniPrimary (citable) accession number: C0LGD7
Secondary accession number(s): Q9M9Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3