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C0LGD7

- Y1684_ARATH

UniProt

C0LGD7 - Y1684_ARATH

Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g06840

Gene

At1g06840

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei653 – 6531ATPPROSITE-ProRule annotation
    Active sitei749 – 7491Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi631 – 6399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G06840-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable LRR receptor-like serine/threonine-protein kinase At1g06840 (EC:2.7.11.1)
    Gene namesi
    Ordered Locus Names:At1g06840
    ORF Names:F4H5.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G06840.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 953925Probable LRR receptor-like serine/threonine-protein kinase At1g06840PRO_0000387540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi411 – 4111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiC0LGD7.
    PRIDEiC0LGD7.

    Interactioni

    Protein-protein interaction databases

    BioGridi22437. 1 interaction.
    STRINGi3702.AT1G06840.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliC0LGD7.
    SMRiC0LGD7. Positions 36-555, 600-895.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 563535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini585 – 953369CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei564 – 58421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati85 – 10622LRR 1Add
    BLAST
    Repeati107 – 13024LRR 2Add
    BLAST
    Repeati132 – 15524LRR 3Add
    BLAST
    Repeati156 – 17722LRR 4Add
    BLAST
    Repeati180 – 20324LRR 5Add
    BLAST
    Repeati204 – 22623LRR 6Add
    BLAST
    Repeati228 – 25124LRR 7Add
    BLAST
    Repeati253 – 27523LRR 8Add
    BLAST
    Repeati276 – 29823LRR 9Add
    BLAST
    Repeati299 – 32224LRR 10Add
    BLAST
    Repeati323 – 34523LRR 11Add
    BLAST
    Repeati352 – 37322LRR 12Add
    BLAST
    Repeati374 – 39522LRR 13Add
    BLAST
    Domaini625 – 897273Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Repeati845 – 86824LRR 14Add
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 14 LRR (leucine-rich) repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116556.
    OMAiFMWNKIT.
    PhylomeDBiC0LGD7.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF13855. LRR_8. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: C0LGD7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND    50
    PVHRLRNWKH GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS 100
    PELGRLSRLT ILSFMWNKIT GSIPKEIGNI KSLELLLLNG NLLNGNLPEE 150
    LGFLPNLDRI QIDENRISGP LPKSFANLNK TKHFHMNNNS ISGQIPPELG 200
    SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD GTTIPQSYGN 250
    MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI 300
    TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS 350
    TESIIVDLRN NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE 400
    EDINQGSTNS NTTICSDCPP PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS 450
    DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ WQKGPRLRMY LKFFPVFGSN 500
    ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL LDVYRDVFPS 550
    ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS 600
    SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV 650
    AIKRAQEGSL QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY 700
    MENGTLRDNI SVKLKEPLDF AMRLRIALGS AKGILYLHTE ANPPIFHRDI 750
    KASNILLDSR FTAKVADFGL SRLAPVPDME GISPQHVSTV VKGTPGYLDP 800
    EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE INIAYESGSI 850
    LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL 900
    MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV 950
    APR 953

    Note: Derived from EST data. No experimental confirmation available.

    Length:953
    Mass (Da):105,625
    Last modified:November 3, 2009 - v2
    Checksum:iC2EF7F0F4100FDCC
    GO
    Isoform 2 (identifier: C0LGD7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         695-700: MLVYEY → RADAGL
         701-953: Missing.

    Show »
    Length:700
    Mass (Da):77,571
    Checksum:iEF4AB3DE4381885A
    GO

    Sequence cautioni

    The sequence AAF63151.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei695 – 7006MLVYEY → RADAGL in isoform 2. 1 PublicationVSP_038290
    Alternative sequencei701 – 953253Missing in isoform 2. 1 PublicationVSP_038291Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011001 Genomic DNA. Translation: AAF63151.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28044.1.
    FJ708626 mRNA. Translation: ACN59222.1.
    PIRiC86203.
    RefSeqiNP_172169.2. NM_100561.3. [C0LGD7-1]
    UniGeneiAt.42324.

    Genome annotation databases

    EnsemblPlantsiAT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
    GeneIDi837196.
    KEGGiath:AT1G06840.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011001 Genomic DNA. Translation: AAF63151.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28044.1 .
    FJ708626 mRNA. Translation: ACN59222.1 .
    PIRi C86203.
    RefSeqi NP_172169.2. NM_100561.3. [C0LGD7-1 ]
    UniGenei At.42324.

    3D structure databases

    ProteinModelPortali C0LGD7.
    SMRi C0LGD7. Positions 36-555, 600-895.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 22437. 1 interaction.
    STRINGi 3702.AT1G06840.1-P.

    Proteomic databases

    PaxDbi C0LGD7.
    PRIDEi C0LGD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G06840.1 ; AT1G06840.1 ; AT1G06840 . [C0LGD7-1 ]
    GeneIDi 837196.
    KEGGi ath:AT1G06840.

    Organism-specific databases

    GeneFarmi 2390. 52.
    TAIRi AT1G06840.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116556.
    OMAi FMWNKIT.
    PhylomeDBi C0LGD7.

    Enzyme and pathway databases

    BioCyci ARA:AT1G06840-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR013210. LRR-contain_N2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF13855. LRR_8. 1 hit.
    PF08263. LRRNT_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
      Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
      BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    4. Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiY1684_ARATH
    AccessioniPrimary (citable) accession number: C0LGD7
    Secondary accession number(s): Q9M9Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3