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C0LGD7

- Y1684_ARATH

UniProt

C0LGD7 - Y1684_ARATH

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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g06840

Gene
At1g06840, F4H5.8
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATP By similarity
Active sitei749 – 7491Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi631 – 6399ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G06840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g06840 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g06840
ORF Names:F4H5.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G06840.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 563535Extracellular Reviewed predictionAdd
BLAST
Transmembranei564 – 58421Helical; Reviewed predictionAdd
BLAST
Topological domaini585 – 953369Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 953925Probable LRR receptor-like serine/threonine-protein kinase At1g06840PRO_0000387540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi411 – 4111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi502 – 5021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi508 – 5081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi537 – 5371N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiC0LGD7.
PRIDEiC0LGD7.

Interactioni

Protein-protein interaction databases

BioGridi22437. 1 interaction.
STRINGi3702.AT1G06840.1-P.

Structurei

3D structure databases

ProteinModelPortaliC0LGD7.
SMRiC0LGD7. Positions 36-555, 600-895.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati85 – 10622LRR 1Add
BLAST
Repeati107 – 13024LRR 2Add
BLAST
Repeati132 – 15524LRR 3Add
BLAST
Repeati156 – 17722LRR 4Add
BLAST
Repeati180 – 20324LRR 5Add
BLAST
Repeati204 – 22623LRR 6Add
BLAST
Repeati228 – 25124LRR 7Add
BLAST
Repeati253 – 27523LRR 8Add
BLAST
Repeati276 – 29823LRR 9Add
BLAST
Repeati299 – 32224LRR 10Add
BLAST
Repeati323 – 34523LRR 11Add
BLAST
Repeati352 – 37322LRR 12Add
BLAST
Repeati374 – 39522LRR 13Add
BLAST
Domaini625 – 897273Protein kinaseAdd
BLAST
Repeati845 – 86824LRR 14Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116556.
OMAiFMWNKIT.
PhylomeDBiC0LGD7.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: C0LGD7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND    50
PVHRLRNWKH GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS 100
PELGRLSRLT ILSFMWNKIT GSIPKEIGNI KSLELLLLNG NLLNGNLPEE 150
LGFLPNLDRI QIDENRISGP LPKSFANLNK TKHFHMNNNS ISGQIPPELG 200
SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD GTTIPQSYGN 250
MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI 300
TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS 350
TESIIVDLRN NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE 400
EDINQGSTNS NTTICSDCPP PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS 450
DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ WQKGPRLRMY LKFFPVFGSN 500
ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL LDVYRDVFPS 550
ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS 600
SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV 650
AIKRAQEGSL QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY 700
MENGTLRDNI SVKLKEPLDF AMRLRIALGS AKGILYLHTE ANPPIFHRDI 750
KASNILLDSR FTAKVADFGL SRLAPVPDME GISPQHVSTV VKGTPGYLDP 800
EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE INIAYESGSI 850
LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL 900
MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV 950
APR 953

Note: Derived from EST data. No experimental confirmation available.

Length:953
Mass (Da):105,625
Last modified:November 3, 2009 - v2
Checksum:iC2EF7F0F4100FDCC
GO
Isoform 2 (identifier: C0LGD7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     695-700: MLVYEY → RADAGL
     701-953: Missing.

Show »
Length:700
Mass (Da):77,571
Checksum:iEF4AB3DE4381885A
GO

Sequence cautioni

The sequence AAF63151.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei695 – 7006MLVYEY → RADAGL in isoform 2. VSP_038290
Alternative sequencei701 – 953253Missing in isoform 2. VSP_038291Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011001 Genomic DNA. Translation: AAF63151.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1.
FJ708626 mRNA. Translation: ACN59222.1.
PIRiC86203.
RefSeqiNP_172169.2. NM_100561.3. [C0LGD7-1]
UniGeneiAt.42324.

Genome annotation databases

EnsemblPlantsiAT1G06840.1; AT1G06840.1; AT1G06840. [C0LGD7-1]
GeneIDi837196.
KEGGiath:AT1G06840.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011001 Genomic DNA. Translation: AAF63151.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1 .
FJ708626 mRNA. Translation: ACN59222.1 .
PIRi C86203.
RefSeqi NP_172169.2. NM_100561.3. [C0LGD7-1 ]
UniGenei At.42324.

3D structure databases

ProteinModelPortali C0LGD7.
SMRi C0LGD7. Positions 36-555, 600-895.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 22437. 1 interaction.
STRINGi 3702.AT1G06840.1-P.

Proteomic databases

PaxDbi C0LGD7.
PRIDEi C0LGD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G06840.1 ; AT1G06840.1 ; AT1G06840 . [C0LGD7-1 ]
GeneIDi 837196.
KEGGi ath:AT1G06840.

Organism-specific databases

GeneFarmi 2390. 52.
TAIRi AT1G06840.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000116556.
OMAi FMWNKIT.
PhylomeDBi C0LGD7.

Enzyme and pathway databases

BioCyci ARA:AT1G06840-MONOMER.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiY1684_ARATH
AccessioniPrimary (citable) accession number: C0LGD7
Secondary accession number(s): Q9M9Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 11, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi