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C0LGD7 (Y1684_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g06840
EC=2.7.11.1
Gene names
Ordered Locus Names:At1g06840
ORF Names:F4H5.8
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length953 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 14 LRR (leucine-rich) repeats.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAF63151.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: C0LGD7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Derived from EST data. No experimental confirmation available.
Isoform 2 (identifier: C0LGD7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     695-700: MLVYEY → RADAGL
     701-953: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 953925Probable LRR receptor-like serine/threonine-protein kinase At1g06840
PRO_0000387540

Regions

Topological domain29 – 563535Extracellular Potential
Transmembrane564 – 58421Helical; Potential
Topological domain585 – 953369Cytoplasmic Potential
Repeat85 – 10622LRR 1
Repeat107 – 13024LRR 2
Repeat132 – 15524LRR 3
Repeat156 – 17722LRR 4
Repeat180 – 20324LRR 5
Repeat204 – 22623LRR 6
Repeat228 – 25124LRR 7
Repeat253 – 27523LRR 8
Repeat276 – 29823LRR 9
Repeat299 – 32224LRR 10
Repeat323 – 34523LRR 11
Repeat352 – 37322LRR 12
Repeat374 – 39522LRR 13
Domain625 – 897273Protein kinase
Repeat845 – 86824LRR 14
Nucleotide binding631 – 6399ATP By similarity

Sites

Active site7491Proton acceptor By similarity
Binding site6531ATP By similarity

Amino acid modifications

Modified residue7831Phosphoserine Ref.5
Modified residue9091Phosphothreonine Ref.5
Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation2881N-linked (GlcNAc...) Potential
Glycosylation3071N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation4111N-linked (GlcNAc...) Potential
Glycosylation5021N-linked (GlcNAc...) Potential
Glycosylation5081N-linked (GlcNAc...) Potential
Glycosylation5371N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence695 – 7006MLVYEY → RADAGL in isoform 2.
VSP_038290
Alternative sequence701 – 953253Missing in isoform 2.
VSP_038291

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 3, 2009. Version 2.
Checksum: C2EF7F0F4100FDCC

FASTA953105,625
        10         20         30         40         50         60 
MFSTHHVSRL LIPLLFFFLF CCFSSTFAQD DITNPVEVRA LRVIKESLND PVHRLRNWKH 

        70         80         90        100        110        120 
GDPCNSNWTG VVCFNSTLDD GYLHVSELQL FSMNLSGNLS PELGRLSRLT ILSFMWNKIT 

       130        140        150        160        170        180 
GSIPKEIGNI KSLELLLLNG NLLNGNLPEE LGFLPNLDRI QIDENRISGP LPKSFANLNK 

       190        200        210        220        230        240 
TKHFHMNNNS ISGQIPPELG SLPSIVHILL DNNNLSGYLP PELSNMPRLL ILQLDNNHFD 

       250        260        270        280        290        300 
GTTIPQSYGN MSKLLKMSLR NCSLQGPVPD LSSIPNLGYL DLSQNQLNGS IPAGKLSDSI 

       310        320        330        340        350        360 
TTIDLSNNSL TGTIPTNFSG LPRLQKLSLA NNALSGSIPS RIWQERELNS TESIIVDLRN 

       370        380        390        400        410        420 
NGFSNISGRS DLRPNVTVWL QGNPLCSDGN LLRLCGPITE EDINQGSTNS NTTICSDCPP 

       430        440        450        460        470        480 
PYEFSPEPLR RCFCAAPLLV GYRLKSPGFS DFVPYRSEFE QYITSGLSLN LYQLRLDSFQ 

       490        500        510        520        530        540 
WQKGPRLRMY LKFFPVFGSN ANNSFIFNRS EVRRIRGMFT GWNIRDEDLF GPYELMNFTL 

       550        560        570        580        590        600 
LDVYRDVFPS ASPSGLSNGA VAGIVLGSVA AAVTLTAIIA LIIMRKRMRG YSAVARRKRS 

       610        620        630        640        650        660 
SKASLKIEGV KSFTYAELAL ATDNFNSSTQ IGQGGYGKVY KGTLGSGTVV AIKRAQEGSL 

       670        680        690        700        710        720 
QGEKEFLTEI ELLSRLHHRN LVSLLGFCDE EGEQMLVYEY MENGTLRDNI SVKLKEPLDF 

       730        740        750        760        770        780 
AMRLRIALGS AKGILYLHTE ANPPIFHRDI KASNILLDSR FTAKVADFGL SRLAPVPDME 

       790        800        810        820        830        840 
GISPQHVSTV VKGTPGYLDP EYFLTHQLTD KSDVYSLGVV LLELFTGMQP ITHGKNIVRE 

       850        860        870        880        890        900 
INIAYESGSI LSTVDKRMSS VPDECLEKFA TLALRCCREE TDARPSMAEV VRELEIIWEL 

       910        920        930        940        950 
MPESHVAKTA DLSETMTHPS SSSNSSIMKH HYTSMDVSGS DLVSGVAPSV APR

« Hide

Isoform 2 [UniParc].

Checksum: EF4AB3DE4381885A
Show »

FASTA70077,571

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: cv. Columbia.
[4]"Mapping the Arabidopsis organelle proteome."
Dunkley T.P.J., Hester S., Shadforth I.P., Runions J., Weimar T., Hanton S.L., Griffin J.L., Bessant C., Brandizzi F., Hawes C., Watson R.B., Dupree P., Lilley K.S.
Proc. Natl. Acad. Sci. U.S.A. 103:6518-6523(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
[5]"Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis."
Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M., Menke F.L.H.
Mol. Cell. Proteomics 6:1198-1214(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-783 AND THR-909, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
Strain: cv. Columbia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC011001 Genomic DNA. Translation: AAF63151.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28044.1.
FJ708626 mRNA. Translation: ACN59222.1.
IPIIPI00540049.
IPI00953805.
PIRC86203.
RefSeqNP_172169.2. NM_100561.3.
UniGeneAt.42324.

3D structure databases

ProteinModelPortalC0LGD7.
SMRC0LGD7. Positions 31-385, 571-923.
ModBaseSearch...

Protein-protein interaction databases

STRING3702.AT1G06840.1-P.

Proteomic databases

PaxDbC0LGD7.
PRIDEC0LGD7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G06840.1; AT1G06840.1; AT1G06840.
GeneID837196.
KEGGath:AT1G06840.

Organism-specific databases

GeneFarm2390. 52.
TAIRAt1g06840.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000116556.
OMAGFLPNLD.
PhylomeDBC0LGD7.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR013320. ConA-like_subgrp.
IPR011009. Kinase-like_dom.
IPR013210. LRR-contain_N2.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY1684_ARATH
AccessionPrimary (citable) accession number: C0LGD7
Secondary accession number(s): Q9M9Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 1, 2013
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents