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C0JPT7 (C0JPT7_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Filamin, alpha (Predicted), isoform CRA_a EMBL EDL84989.1

Protein Flna Ensembl ENSRNOP00000062690
Gene names
Name:Flna RGD 1560614 Ensembl ENSRNOP00000062690 EMBL ACN49086.1
Synonyms:Flna_predicted EMBL EDL84989.1
ORF Names:rCG_43821 EMBL EDL84989.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length2639 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   DomainRepeat SAAS SAAS001589
   LigandActin-binding SAAS SAAS001589
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin crosslink formation

Inferred from mutant phenotype PubMed 22872576. Source: RGD

actin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

adenylate cyclase-inhibiting dopamine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

cilium assembly

Inferred from electronic annotation. Source: Ensembl

cytoplasmic sequestering of protein

Inferred from electronic annotation. Source: Ensembl

early endosome to late endosome transport

Inferred from electronic annotation. Source: Ensembl

epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

establishment of protein localization

Inferred from electronic annotation. Source: Ensembl

mRNA transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20167606. Source: RGD

negative regulation of protein catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription factor import into nucleus

Inferred from electronic annotation. Source: Ensembl

protein localization to cell surface

Inferred from electronic annotation. Source: Ensembl

protein stabilization

Inferred from electronic annotation. Source: Ensembl

receptor clustering

Inferred from electronic annotation. Source: Ensembl

spindle assembly involved in mitosis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentMyb complex

Inferred from electronic annotation. Source: Ensembl

actin cytoskeleton

Inferred from direct assay PubMed 20167606. Source: RGD

actin filament

Inferred from direct assay PubMed 15661894. Source: RGD

apical dendrite

Inferred from direct assay PubMed 22434607. Source: RGD

cortical cytoskeleton

Inferred from direct assay PubMed 15661894. Source: RGD

cytosol

Inferred from direct assay PubMed 15661894. Source: RGD

dendritic shaft

Inferred from direct assay PubMed 22434607. Source: RGD

extracellular vesicular exosome

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from direct assay PubMed 22434607. Source: RGD

nucleus

Inferred from direct assay PubMed 20167606. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 20167606. Source: RGD

plasma membrane

Inferred from electronic annotation. Source: Ensembl

protein complex

Inferred from mutant phenotype PubMed 22872576. Source: RGD

trans-Golgi network

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionSMAD binding

Inferred from physical interaction PubMed 20167606. Source: RGD

mu-type opioid receptor binding

Inferred from mutant phenotype PubMed 19172190. Source: RGD

signal transducer activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C0JPT7 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: 8A5466979F8179A3

FASTA2,639280,495
        10         20         30         40         50         60 
MSSSHSRSGQ SAAGASPAGG IDTRDAEMPA TEKDLAEDAP WKKIQQNTFT RWCNEHLKCV 

        70         80         90        100        110        120 
SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR QMQLENVSVA LEFLDRESIK 

       130        140        150        160        170        180 
LVSIDSKAIV DGNLKLILGL IWTLILHYSI SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL 

       190        200        210        220        230        240 
PQLPITNFSR DWQSGRALGA LVDSCAPGLC PDWDSWDASK PVNNAREAMQ QADDWLGIPQ 

       250        260        270        280        290        300 
VITPEEIVDP NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK 

       310        320        330        340        350        360 
RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV TGTHKVTVLF 

       370        380        390        400        410        420 
AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK TTYFEIFTAG AGIGEVEVVI 

       430        440        450        460        470        480 
QDPTGQKGTV EPQLEARGDS TYRCSYQPTM EGVHTVHVTF AGVPIPRSPY TVTVGQACNP 

       490        500        510        520        530        540 
TACRAVGRGL QPKGVRVKET ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF 

       550        560        570        580        590        600 
EYYPTIPGTY TVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGI VGKSADFVVE 

       610        620        630        640        650        660 
AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN SEDIRLSPFM 

       670        680        690        700        710        720 
ADIREAPQDF HPDRVKARGP GLEKTGVAIN KPAEFTVDAK HAGKAPLRVQ VQDNEGHSVE 

       730        740        750        760        770        780 
TTVKDNGNGT YSCSYVPRKP VKHTAMVSWG GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA 

       790        800        810        820        830        840 
KTGLKAHEPT YFTVDCTEAG QGDVSIGIKC APGVVGPTEA DIDFDIIRND NDTFTVKYTP 

       850        860        870        880        890        900 
CGAGSYTIMV LFADQATPTS PIRVKVEPSH DASKVKAEGP GLNRTGVELG KPTHFTVNAK 

       910        920        930        940        950        960 
TAGKGKLDVQ FSGLAKGDAV RDVDIIDHHD NTYTVKYTPV QQGPVGVSVT YGGDHIPKSP 

       970        980        990       1000       1010       1020 
FSVGVSPSLD LSKIKVSGLV DKVDVGKDQE FTVKSKGAGG QGKVASKIVS PSGAAVPCKV 

      1030       1040       1050       1060       1070       1080 
EPGLGADNSV VRFVPREEGP YEVEVTYDGV PVPGSPFPVE AVAPTKPSKV KAFGPGLQGG 

      1090       1100       1110       1120       1130       1140 
NAGSPARFTI DTKGAGTGGL GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF 

      1150       1160       1170       1180       1190       1200 
ADTHIPGSPF KAHVVPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE 

      1210       1220       1230       1240       1250       1260 
AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE PAVDTSGVQC 

      1270       1280       1290       1300       1310       1320 
YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP SGNLTDTYVQ DCGDGTYKVE 

      1330       1340       1350       1360       1370       1380 
YTPYEEGVHS VDVTYDGSPV PSSPFQVPVT EGCDPSRVRV HGPGIQSGTT NKPNKFTVET 

      1390       1400       1410       1420       1430       1440 
RGAGTGGLGL AVEGPSEAKM SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV 

      1450       1460       1470       1480       1490       1500 
PVHDVTDASK VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV 

      1510       1520       1530       1540       1550       1560 
DNADGTQTVN YVPSREGSYS ISVLYGEEEV PRSPFKVKVL PTHDASKVKA SGPGLNTTGV 

      1570       1580       1590       1600       1610       1620 
PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH DGTYTVAYVP DVTGRYTILI 

      1630       1640       1650       1660       1670       1680 
KYGGDEIPFS PYRVRAVPTG DASKCTVTGA GIGPTIQIGE ETVITVDTKA AGKGKVTCTV 

      1690       1700       1710       1720       1730       1740 
CTPDGSEVDV DVVENEDGTF DIFYTAPQPG KYVICVRFGG EHVPNSPFQV TALAGDQPTV 

      1750       1760       1770       1780       1790       1800 
QTPLRPQQLP SQYTYPQGSQ QTWIPERPMV GVNGLDVTSL RPFDLVIPFT IKKGEITGEV 

      1810       1820       1830       1840       1850       1860 
RMPSGKVAQP SITDNKDGTV TVRYSPSEAG LHEMDIRYDN MHIPGSPLQF YVDYVNCGHI 

      1870       1880       1890       1900       1910       1920 
TAYGPGLTHG VVNKPATFTV NTKDAGEGGL SLAIEGPSKA EISCTDNQDG TCSVSYLPVL 

      1930       1940       1950       1960       1970       1980 
PGDYSILVKY NDQHIPGSPF TARVTGDDSM RMSHLKVGSA ADIPINISET DLSLLTATVV 

      1990       2000       2010       2020       2030       2040 
PPSGREEPCL LKRLRNGHVG ISFVPKETGE HLVHVKKNGQ HVASSPIPVV ISQSEIGDAS 

      2050       2060       2070       2080       2090       2100 
RVRVSGQGLH EGHTFEPAEF IIDTRDAGYG GLSLSIEGPS KVDINTEDLE DGTCRVTYCP 

      2110       2120       2130       2140       2150       2160 
TEPGNYIINI KFADQHVPGS PFSVKVTGEG RVKESITRRR RAPSVANVGS HCDLSLKIPE 

      2170       2180       2190       2200       2210       2220 
ISIQDMTAQV TSPSGKTHEA EIVEGENHTY CIRFVPAEMG MHTVSVKYKG QHVPGSPFQF 

      2230       2240       2250       2260       2270       2280 
TVGPLGEGGA HKVRAGGPGL ERAEAGVPAE FGIWTREAGA GGLAIAVEGP SKAEISFEDR 

      2290       2300       2310       2320       2330       2340 
KDGSCGVAYV VQEPGDYEVS VKFNEEHIPD SPFVVPVASP SGDARRLTVS SLQESGLKVN 

      2350       2360       2370       2380       2390       2400 
QPASFAVSLN GAKGAIDAKV HSPSGALEEC YVTEIDQDKY AVRFIPRENG VYLIDVKFNG 

      2410       2420       2430       2440       2450       2460 
THIPGSPFKI RVGEPGHGGD PGLVSAYGAG LEGGVTGSPA EFIVNTSNAG AGALSVTIDG 

      2470       2480       2490       2500       2510       2520 
PSKVKMDCQE CPEGYRVTYT PMAPGSYLIS IKYGGPYHIG GSPFKAKVTG PRLVSNHSLH 

      2530       2540       2550       2560       2570       2580 
ETSSVFVDSL TKVATVPQHA TSGPGPADVS KVVAKGLGLS KAYVGQKSNF TVDCSKAGNN 

      2590       2600       2610       2620       2630 
MLLVGVHGPR TPCEEILVKH MGSRLYSVSY LLKDKGEYTL VVKWGDEHIP GSPYRIMVP 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000062690.
[2]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL84989.1.
[3]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL84989.1.
[4]"A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A."
Carabalona A., Beguin S., Pallesi-Pocachard E., Buhler E., Pellegrino C., Arnaud K., Hubert P., Oualha M., Siffroi J.P., Khantane S., Coupry I., Goizet C., Gelot A.B., Represa A., Cardoso C.
Hum. Mol. Genet. 21:1004-1017(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL ACN49086.1.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000062690.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06006956 Genomic DNA. No translation available.
FJ416060 mRNA. Translation: ACN49086.1.
CH474099 Genomic DNA. Translation: EDL84989.1.
RefSeqNP_001128071.1. NM_001134599.1.
XP_006229632.1. XM_006229570.1.
UniGeneRn.4213.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000068489; ENSRNOP00000062690; ENSRNOG00000037239.
GeneID293860.
KEGGrno:293860.

Organism-specific databases

CTD2316.
RGD1560614. Flna.

Phylogenomic databases

eggNOGCOG5069.
GeneTreeENSGT00660000095431.
HOGENOMHOG000044235.
KOK04437.
OMAPGVAKTG.
OrthoDBEOG76T9QC.

Gene expression databases

GenevestigatorC0JPT7.

Family and domain databases

Gene3D1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio637159.

Entry information

Entry nameC0JPT7_RAT
AccessionPrimary (citable) accession number: C0JPT7
Entry history
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)