Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C0JPT7

- C0JPT7_RAT

UniProt

C0JPT7 - C0JPT7_RAT

Protein
Submitted name:

Filamin alpha

Gene

Flna

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. mu-type opioid receptor binding Source: RGD
    2. protein binding Source: RGD
    3. signal transducer activity Source: Ensembl
    4. SMAD binding Source: RGD

    GO - Biological processi

    1. actin crosslink formation Source: RGD
    2. actin cytoskeleton reorganization Source: Ensembl
    3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
    4. cilium assembly Source: Ensembl
    5. cytoplasmic sequestering of protein Source: Ensembl
    6. early endosome to late endosome transport Source: Ensembl
    7. epithelial to mesenchymal transition Source: Ensembl
    8. establishment of protein localization Source: Ensembl
    9. mRNA transcription from RNA polymerase II promoter Source: RGD
    10. negative regulation of protein catabolic process Source: Ensembl
    11. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    13. positive regulation of transcription factor import into nucleus Source: Ensembl
    14. protein localization to cell surface Source: Ensembl
    15. protein stabilization Source: Ensembl
    16. receptor clustering Source: Ensembl
    17. spindle assembly involved in mitosis Source: Ensembl

    Keywords - Ligandi

    Actin-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Filamin alphaImported
    Submitted name:
    Filamin, alpha (Predicted), isoform CRA_aImported
    Submitted name:
    Protein FlnaImported
    Gene namesi
    Name:FlnaImported
    Synonyms:Flna_predictedImported
    ORF Names:rCG_43821Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1560614. Flna.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: RGD
    2. actin filament Source: RGD
    3. apical dendrite Source: RGD
    4. cortical cytoskeleton Source: RGD
    5. cytosol Source: RGD
    6. dendritic shaft Source: RGD
    7. extracellular vesicular exosome Source: Ensembl
    8. Myb complex Source: Ensembl
    9. neuronal cell body Source: RGD
    10. nucleus Source: RGD
    11. perinuclear region of cytoplasm Source: RGD
    12. plasma membrane Source: Ensembl
    13. protein complex Source: RGD
    14. trans-Golgi network Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriC0JPT7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008910.

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    eggNOGiCOG5069.
    GeneTreeiENSGT00660000095431.
    HOGENOMiHOG000044235.
    KOiK04437.
    OMAiVQVQDNE.
    OrthoDBiEOG76T9QC.

    Family and domain databases

    Gene3Di1.10.418.10. 2 hits.
    2.60.40.10. 24 hits.
    InterProiIPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR028559. FLN.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
    PfamiPF00307. CH. 2 hits.
    PF00630. Filamin. 23 hits.
    [Graphical view]
    SMARTiSM00033. CH. 2 hits.
    SM00557. IG_FLMN. 24 hits.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF81296. SSF81296. 24 hits.
    PROSITEiPS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS50194. FILAMIN_REPEAT. 24 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0JPT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSHSRSGQ SAAGASPAGG IDTRDAEMPA TEKDLAEDAP WKKIQQNTFT     50
    RWCNEHLKCV SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR 100
    QMQLENVSVA LEFLDRESIK LVSIDSKAIV DGNLKLILGL IWTLILHYSI 150
    SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL PQLPITNFSR DWQSGRALGA 200
    LVDSCAPGLC PDWDSWDASK PVNNAREAMQ QADDWLGIPQ VITPEEIVDP 250
    NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK 300
    RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV 350
    TGTHKVTVLF AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK 400
    TTYFEIFTAG AGIGEVEVVI QDPTGQKGTV EPQLEARGDS TYRCSYQPTM 450
    EGVHTVHVTF AGVPIPRSPY TVTVGQACNP TACRAVGRGL QPKGVRVKET 500
    ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF EYYPTIPGTY 550
    TVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGI VGKSADFVVE 600
    AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN 650
    SEDIRLSPFM ADIREAPQDF HPDRVKARGP GLEKTGVAIN KPAEFTVDAK 700
    HAGKAPLRVQ VQDNEGHSVE TTVKDNGNGT YSCSYVPRKP VKHTAMVSWG 750
    GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA KTGLKAHEPT YFTVDCTEAG 800
    QGDVSIGIKC APGVVGPTEA DIDFDIIRND NDTFTVKYTP CGAGSYTIMV 850
    LFADQATPTS PIRVKVEPSH DASKVKAEGP GLNRTGVELG KPTHFTVNAK 900
    TAGKGKLDVQ FSGLAKGDAV RDVDIIDHHD NTYTVKYTPV QQGPVGVSVT 950
    YGGDHIPKSP FSVGVSPSLD LSKIKVSGLV DKVDVGKDQE FTVKSKGAGG 1000
    QGKVASKIVS PSGAAVPCKV EPGLGADNSV VRFVPREEGP YEVEVTYDGV 1050
    PVPGSPFPVE AVAPTKPSKV KAFGPGLQGG NAGSPARFTI DTKGAGTGGL 1100
    GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF ADTHIPGSPF 1150
    KAHVVPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE 1200
    AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE 1250
    PAVDTSGVQC YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP 1300
    SGNLTDTYVQ DCGDGTYKVE YTPYEEGVHS VDVTYDGSPV PSSPFQVPVT 1350
    EGCDPSRVRV HGPGIQSGTT NKPNKFTVET RGAGTGGLGL AVEGPSEAKM 1400
    SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV PVHDVTDASK 1450
    VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV 1500
    DNADGTQTVN YVPSREGSYS ISVLYGEEEV PRSPFKVKVL PTHDASKVKA 1550
    SGPGLNTTGV PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH 1600
    DGTYTVAYVP DVTGRYTILI KYGGDEIPFS PYRVRAVPTG DASKCTVTGA 1650
    GIGPTIQIGE ETVITVDTKA AGKGKVTCTV CTPDGSEVDV DVVENEDGTF 1700
    DIFYTAPQPG KYVICVRFGG EHVPNSPFQV TALAGDQPTV QTPLRPQQLP 1750
    SQYTYPQGSQ QTWIPERPMV GVNGLDVTSL RPFDLVIPFT IKKGEITGEV 1800
    RMPSGKVAQP SITDNKDGTV TVRYSPSEAG LHEMDIRYDN MHIPGSPLQF 1850
    YVDYVNCGHI TAYGPGLTHG VVNKPATFTV NTKDAGEGGL SLAIEGPSKA 1900
    EISCTDNQDG TCSVSYLPVL PGDYSILVKY NDQHIPGSPF TARVTGDDSM 1950
    RMSHLKVGSA ADIPINISET DLSLLTATVV PPSGREEPCL LKRLRNGHVG 2000
    ISFVPKETGE HLVHVKKNGQ HVASSPIPVV ISQSEIGDAS RVRVSGQGLH 2050
    EGHTFEPAEF IIDTRDAGYG GLSLSIEGPS KVDINTEDLE DGTCRVTYCP 2100
    TEPGNYIINI KFADQHVPGS PFSVKVTGEG RVKESITRRR RAPSVANVGS 2150
    HCDLSLKIPE ISIQDMTAQV TSPSGKTHEA EIVEGENHTY CIRFVPAEMG 2200
    MHTVSVKYKG QHVPGSPFQF TVGPLGEGGA HKVRAGGPGL ERAEAGVPAE 2250
    FGIWTREAGA GGLAIAVEGP SKAEISFEDR KDGSCGVAYV VQEPGDYEVS 2300
    VKFNEEHIPD SPFVVPVASP SGDARRLTVS SLQESGLKVN QPASFAVSLN 2350
    GAKGAIDAKV HSPSGALEEC YVTEIDQDKY AVRFIPRENG VYLIDVKFNG 2400
    THIPGSPFKI RVGEPGHGGD PGLVSAYGAG LEGGVTGSPA EFIVNTSNAG 2450
    AGALSVTIDG PSKVKMDCQE CPEGYRVTYT PMAPGSYLIS IKYGGPYHIG 2500
    GSPFKAKVTG PRLVSNHSLH ETSSVFVDSL TKVATVPQHA TSGPGPADVS 2550
    KVVAKGLGLS KAYVGQKSNF TVDCSKAGNN MLLVGVHGPR TPCEEILVKH 2600
    MGSRLYSVSY LLKDKGEYTL VVKWGDEHIP GSPYRIMVP 2639
    Length:2,639
    Mass (Da):280,495
    Last modified:May 5, 2009 - v1
    Checksum:i8A5466979F8179A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06006956 Genomic DNA. No translation available.
    FJ416060 mRNA. Translation: ACN49086.1.
    CH474099 Genomic DNA. Translation: EDL84989.1.
    RefSeqiNP_001128071.1. NM_001134599.1.
    XP_006229632.1. XM_006229570.1.
    UniGeneiRn.4213.

    Genome annotation databases

    EnsembliENSRNOT00000068489; ENSRNOP00000062690; ENSRNOG00000037239.
    GeneIDi293860.
    KEGGirno:293860.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06006956 Genomic DNA. No translation available.
    FJ416060 mRNA. Translation: ACN49086.1 .
    CH474099 Genomic DNA. Translation: EDL84989.1 .
    RefSeqi NP_001128071.1. NM_001134599.1.
    XP_006229632.1. XM_006229570.1.
    UniGenei Rn.4213.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068489 ; ENSRNOP00000062690 ; ENSRNOG00000037239 .
    GeneIDi 293860.
    KEGGi rno:293860.

    Organism-specific databases

    CTDi 2316.
    RGDi 1560614. Flna.

    Phylogenomic databases

    eggNOGi COG5069.
    GeneTreei ENSGT00660000095431.
    HOGENOMi HOG000044235.
    KOi K04437.
    OMAi VQVQDNE.
    OrthoDBi EOG76T9QC.

    Miscellaneous databases

    NextBioi 637159.

    Gene expression databases

    Genevestigatori C0JPT7.

    Family and domain databases

    Gene3Di 1.10.418.10. 2 hits.
    2.60.40.10. 24 hits.
    InterProi IPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR028559. FLN.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR11915:SF173. PTHR11915:SF173. 1 hit.
    Pfami PF00307. CH. 2 hits.
    PF00630. Filamin. 23 hits.
    [Graphical view ]
    SMARTi SM00033. CH. 2 hits.
    SM00557. IG_FLMN. 24 hits.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF81296. SSF81296. 24 hits.
    PROSITEi PS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS50194. FILAMIN_REPEAT. 24 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiC0JPT7_RAT
    AccessioniPrimary (citable) accession number: C0JPT7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3