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C0JPT7

- C0JPT7_RAT

UniProt

C0JPT7 - C0JPT7_RAT

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Protein
Submitted name: Filamin alpha
Gene
Flna, Flna_predicted, rCG_43821
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. SMAD binding Source: RGD
  2. mu-type opioid receptor binding Source: RGD
  3. protein binding Source: RGD
  4. signal transducer activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. actin crosslink formation Source: RGD
  2. actin cytoskeleton reorganization Source: Ensembl
  3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  4. cilium assembly Source: Ensembl
  5. cytoplasmic sequestering of protein Source: Ensembl
  6. early endosome to late endosome transport Source: Ensembl
  7. epithelial to mesenchymal transition Source: Ensembl
  8. establishment of protein localization Source: Ensembl
  9. mRNA transcription from RNA polymerase II promoter Source: RGD
  10. negative regulation of protein catabolic process Source: Ensembl
  11. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  13. positive regulation of transcription factor import into nucleus Source: Ensembl
  14. protein localization to cell surface Source: Ensembl
  15. protein stabilization Source: Ensembl
  16. receptor clustering Source: Ensembl
  17. spindle assembly involved in mitosis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Filamin alphaImported
Submitted name:
Filamin, alpha (Predicted), isoform CRA_aImported
Submitted name:
Protein FlnaImported
Gene namesi
Name:FlnaImported
Synonyms:Flna_predictedImported
ORF Names:rCG_43821Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1560614. Flna.

Subcellular locationi

GO - Cellular componenti

  1. Myb complex Source: Ensembl
  2. actin cytoskeleton Source: RGD
  3. actin filament Source: RGD
  4. apical dendrite Source: RGD
  5. cortical cytoskeleton Source: RGD
  6. cytosol Source: RGD
  7. dendritic shaft Source: RGD
  8. extracellular vesicular exosome Source: Ensembl
  9. neuronal cell body Source: RGD
  10. nucleus Source: RGD
  11. perinuclear region of cytoplasm Source: RGD
  12. plasma membrane Source: Ensembl
  13. protein complex Source: RGD
  14. trans-Golgi network Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriC0JPT7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008910.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotations

Phylogenomic databases

eggNOGiCOG5069.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
KOiK04437.
OMAiVQVQDNE.
OrthoDBiEOG76T9QC.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0JPT7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSHSRSGQ SAAGASPAGG IDTRDAEMPA TEKDLAEDAP WKKIQQNTFT     50
RWCNEHLKCV SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR 100
QMQLENVSVA LEFLDRESIK LVSIDSKAIV DGNLKLILGL IWTLILHYSI 150
SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL PQLPITNFSR DWQSGRALGA 200
LVDSCAPGLC PDWDSWDASK PVNNAREAMQ QADDWLGIPQ VITPEEIVDP 250
NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK 300
RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV 350
TGTHKVTVLF AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK 400
TTYFEIFTAG AGIGEVEVVI QDPTGQKGTV EPQLEARGDS TYRCSYQPTM 450
EGVHTVHVTF AGVPIPRSPY TVTVGQACNP TACRAVGRGL QPKGVRVKET 500
ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF EYYPTIPGTY 550
TVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGI VGKSADFVVE 600
AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN 650
SEDIRLSPFM ADIREAPQDF HPDRVKARGP GLEKTGVAIN KPAEFTVDAK 700
HAGKAPLRVQ VQDNEGHSVE TTVKDNGNGT YSCSYVPRKP VKHTAMVSWG 750
GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA KTGLKAHEPT YFTVDCTEAG 800
QGDVSIGIKC APGVVGPTEA DIDFDIIRND NDTFTVKYTP CGAGSYTIMV 850
LFADQATPTS PIRVKVEPSH DASKVKAEGP GLNRTGVELG KPTHFTVNAK 900
TAGKGKLDVQ FSGLAKGDAV RDVDIIDHHD NTYTVKYTPV QQGPVGVSVT 950
YGGDHIPKSP FSVGVSPSLD LSKIKVSGLV DKVDVGKDQE FTVKSKGAGG 1000
QGKVASKIVS PSGAAVPCKV EPGLGADNSV VRFVPREEGP YEVEVTYDGV 1050
PVPGSPFPVE AVAPTKPSKV KAFGPGLQGG NAGSPARFTI DTKGAGTGGL 1100
GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF ADTHIPGSPF 1150
KAHVVPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE 1200
AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE 1250
PAVDTSGVQC YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP 1300
SGNLTDTYVQ DCGDGTYKVE YTPYEEGVHS VDVTYDGSPV PSSPFQVPVT 1350
EGCDPSRVRV HGPGIQSGTT NKPNKFTVET RGAGTGGLGL AVEGPSEAKM 1400
SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV PVHDVTDASK 1450
VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV 1500
DNADGTQTVN YVPSREGSYS ISVLYGEEEV PRSPFKVKVL PTHDASKVKA 1550
SGPGLNTTGV PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH 1600
DGTYTVAYVP DVTGRYTILI KYGGDEIPFS PYRVRAVPTG DASKCTVTGA 1650
GIGPTIQIGE ETVITVDTKA AGKGKVTCTV CTPDGSEVDV DVVENEDGTF 1700
DIFYTAPQPG KYVICVRFGG EHVPNSPFQV TALAGDQPTV QTPLRPQQLP 1750
SQYTYPQGSQ QTWIPERPMV GVNGLDVTSL RPFDLVIPFT IKKGEITGEV 1800
RMPSGKVAQP SITDNKDGTV TVRYSPSEAG LHEMDIRYDN MHIPGSPLQF 1850
YVDYVNCGHI TAYGPGLTHG VVNKPATFTV NTKDAGEGGL SLAIEGPSKA 1900
EISCTDNQDG TCSVSYLPVL PGDYSILVKY NDQHIPGSPF TARVTGDDSM 1950
RMSHLKVGSA ADIPINISET DLSLLTATVV PPSGREEPCL LKRLRNGHVG 2000
ISFVPKETGE HLVHVKKNGQ HVASSPIPVV ISQSEIGDAS RVRVSGQGLH 2050
EGHTFEPAEF IIDTRDAGYG GLSLSIEGPS KVDINTEDLE DGTCRVTYCP 2100
TEPGNYIINI KFADQHVPGS PFSVKVTGEG RVKESITRRR RAPSVANVGS 2150
HCDLSLKIPE ISIQDMTAQV TSPSGKTHEA EIVEGENHTY CIRFVPAEMG 2200
MHTVSVKYKG QHVPGSPFQF TVGPLGEGGA HKVRAGGPGL ERAEAGVPAE 2250
FGIWTREAGA GGLAIAVEGP SKAEISFEDR KDGSCGVAYV VQEPGDYEVS 2300
VKFNEEHIPD SPFVVPVASP SGDARRLTVS SLQESGLKVN QPASFAVSLN 2350
GAKGAIDAKV HSPSGALEEC YVTEIDQDKY AVRFIPRENG VYLIDVKFNG 2400
THIPGSPFKI RVGEPGHGGD PGLVSAYGAG LEGGVTGSPA EFIVNTSNAG 2450
AGALSVTIDG PSKVKMDCQE CPEGYRVTYT PMAPGSYLIS IKYGGPYHIG 2500
GSPFKAKVTG PRLVSNHSLH ETSSVFVDSL TKVATVPQHA TSGPGPADVS 2550
KVVAKGLGLS KAYVGQKSNF TVDCSKAGNN MLLVGVHGPR TPCEEILVKH 2600
MGSRLYSVSY LLKDKGEYTL VVKWGDEHIP GSPYRIMVP 2639
Length:2,639
Mass (Da):280,495
Last modified:May 5, 2009 - v1
Checksum:i8A5466979F8179A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06006956 Genomic DNA. No translation available.
FJ416060 mRNA. Translation: ACN49086.1.
CH474099 Genomic DNA. Translation: EDL84989.1.
RefSeqiNP_001128071.1. NM_001134599.1.
XP_006229632.1. XM_006229570.1.
UniGeneiRn.4213.

Genome annotation databases

EnsembliENSRNOT00000068489; ENSRNOP00000062690; ENSRNOG00000037239.
GeneIDi293860.
KEGGirno:293860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06006956 Genomic DNA. No translation available.
FJ416060 mRNA. Translation: ACN49086.1 .
CH474099 Genomic DNA. Translation: EDL84989.1 .
RefSeqi NP_001128071.1. NM_001134599.1.
XP_006229632.1. XM_006229570.1.
UniGenei Rn.4213.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068489 ; ENSRNOP00000062690 ; ENSRNOG00000037239 .
GeneIDi 293860.
KEGGi rno:293860.

Organism-specific databases

CTDi 2316.
RGDi 1560614. Flna.

Phylogenomic databases

eggNOGi COG5069.
GeneTreei ENSGT00660000095431.
HOGENOMi HOG000044235.
KOi K04437.
OMAi VQVQDNE.
OrthoDBi EOG76T9QC.

Miscellaneous databases

NextBioi 637159.

Gene expression databases

Genevestigatori C0JPT7.

Family and domain databases

Gene3Di 1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR11915:SF173. PTHR11915:SF173. 1 hit.
Pfami PF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view ]
SMARTi SM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiC0JPT7_RAT
AccessioniPrimary (citable) accession number: C0JPT7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi