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C0JPT7

- C0JPT7_RAT

UniProt

C0JPT7 - C0JPT7_RAT

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Protein
Submitted name:

Filamin alpha

Gene

Flna

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. mu-type opioid receptor binding Source: RGD
  2. poly(A) RNA binding Source: Ensembl
  3. signal transducer activity Source: Ensembl
  4. SMAD binding Source: RGD

GO - Biological processi

  1. actin crosslink formation Source: RGD
  2. actin cytoskeleton reorganization Source: Ensembl
  3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  4. cilium assembly Source: Ensembl
  5. cytoplasmic sequestering of protein Source: Ensembl
  6. early endosome to late endosome transport Source: Ensembl
  7. epithelial to mesenchymal transition Source: Ensembl
  8. establishment of protein localization Source: Ensembl
  9. mRNA transcription from RNA polymerase II promoter Source: RGD
  10. negative regulation of protein catabolic process Source: Ensembl
  11. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  13. positive regulation of transcription factor import into nucleus Source: Ensembl
  14. protein localization to cell surface Source: Ensembl
  15. protein stabilization Source: Ensembl
  16. receptor clustering Source: Ensembl
  17. spindle assembly involved in mitosis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Filamin alphaImported
Submitted name:
Filamin, alpha (Predicted), isoform CRA_aImported
Submitted name:
Protein FlnaImported
Gene namesi
Name:FlnaImported
Synonyms:Flna_predictedImported
ORF Names:rCG_43821Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1560614. Flna.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: RGD
  2. actin filament Source: RGD
  3. apical dendrite Source: RGD
  4. cortical cytoskeleton Source: RGD
  5. cytosol Source: RGD
  6. dendritic shaft Source: RGD
  7. extracellular vesicular exosome Source: Ensembl
  8. Myb complex Source: Ensembl
  9. neuronal cell body Source: RGD
  10. nucleus Source: RGD
  11. perinuclear region of cytoplasm Source: RGD
  12. plasma membrane Source: Ensembl
  13. protein complex Source: RGD
  14. trans-Golgi network Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriC0JPT7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008910.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiCOG5069.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
KOiK04437.
OMAiVQVQDNE.
OrthoDBiEOG76T9QC.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A/C.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0JPT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSHSRSGQ SAAGASPAGG IDTRDAEMPA TEKDLAEDAP WKKIQQNTFT
60 70 80 90 100
RWCNEHLKCV SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR
110 120 130 140 150
QMQLENVSVA LEFLDRESIK LVSIDSKAIV DGNLKLILGL IWTLILHYSI
160 170 180 190 200
SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL PQLPITNFSR DWQSGRALGA
210 220 230 240 250
LVDSCAPGLC PDWDSWDASK PVNNAREAMQ QADDWLGIPQ VITPEEIVDP
260 270 280 290 300
NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK
310 320 330 340 350
RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV
360 370 380 390 400
TGTHKVTVLF AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK
410 420 430 440 450
TTYFEIFTAG AGIGEVEVVI QDPTGQKGTV EPQLEARGDS TYRCSYQPTM
460 470 480 490 500
EGVHTVHVTF AGVPIPRSPY TVTVGQACNP TACRAVGRGL QPKGVRVKET
510 520 530 540 550
ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF EYYPTIPGTY
560 570 580 590 600
TVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGI VGKSADFVVE
610 620 630 640 650
AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN
660 670 680 690 700
SEDIRLSPFM ADIREAPQDF HPDRVKARGP GLEKTGVAIN KPAEFTVDAK
710 720 730 740 750
HAGKAPLRVQ VQDNEGHSVE TTVKDNGNGT YSCSYVPRKP VKHTAMVSWG
760 770 780 790 800
GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA KTGLKAHEPT YFTVDCTEAG
810 820 830 840 850
QGDVSIGIKC APGVVGPTEA DIDFDIIRND NDTFTVKYTP CGAGSYTIMV
860 870 880 890 900
LFADQATPTS PIRVKVEPSH DASKVKAEGP GLNRTGVELG KPTHFTVNAK
910 920 930 940 950
TAGKGKLDVQ FSGLAKGDAV RDVDIIDHHD NTYTVKYTPV QQGPVGVSVT
960 970 980 990 1000
YGGDHIPKSP FSVGVSPSLD LSKIKVSGLV DKVDVGKDQE FTVKSKGAGG
1010 1020 1030 1040 1050
QGKVASKIVS PSGAAVPCKV EPGLGADNSV VRFVPREEGP YEVEVTYDGV
1060 1070 1080 1090 1100
PVPGSPFPVE AVAPTKPSKV KAFGPGLQGG NAGSPARFTI DTKGAGTGGL
1110 1120 1130 1140 1150
GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF ADTHIPGSPF
1160 1170 1180 1190 1200
KAHVVPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE
1210 1220 1230 1240 1250
AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE
1260 1270 1280 1290 1300
PAVDTSGVQC YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP
1310 1320 1330 1340 1350
SGNLTDTYVQ DCGDGTYKVE YTPYEEGVHS VDVTYDGSPV PSSPFQVPVT
1360 1370 1380 1390 1400
EGCDPSRVRV HGPGIQSGTT NKPNKFTVET RGAGTGGLGL AVEGPSEAKM
1410 1420 1430 1440 1450
SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV PVHDVTDASK
1460 1470 1480 1490 1500
VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV
1510 1520 1530 1540 1550
DNADGTQTVN YVPSREGSYS ISVLYGEEEV PRSPFKVKVL PTHDASKVKA
1560 1570 1580 1590 1600
SGPGLNTTGV PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH
1610 1620 1630 1640 1650
DGTYTVAYVP DVTGRYTILI KYGGDEIPFS PYRVRAVPTG DASKCTVTGA
1660 1670 1680 1690 1700
GIGPTIQIGE ETVITVDTKA AGKGKVTCTV CTPDGSEVDV DVVENEDGTF
1710 1720 1730 1740 1750
DIFYTAPQPG KYVICVRFGG EHVPNSPFQV TALAGDQPTV QTPLRPQQLP
1760 1770 1780 1790 1800
SQYTYPQGSQ QTWIPERPMV GVNGLDVTSL RPFDLVIPFT IKKGEITGEV
1810 1820 1830 1840 1850
RMPSGKVAQP SITDNKDGTV TVRYSPSEAG LHEMDIRYDN MHIPGSPLQF
1860 1870 1880 1890 1900
YVDYVNCGHI TAYGPGLTHG VVNKPATFTV NTKDAGEGGL SLAIEGPSKA
1910 1920 1930 1940 1950
EISCTDNQDG TCSVSYLPVL PGDYSILVKY NDQHIPGSPF TARVTGDDSM
1960 1970 1980 1990 2000
RMSHLKVGSA ADIPINISET DLSLLTATVV PPSGREEPCL LKRLRNGHVG
2010 2020 2030 2040 2050
ISFVPKETGE HLVHVKKNGQ HVASSPIPVV ISQSEIGDAS RVRVSGQGLH
2060 2070 2080 2090 2100
EGHTFEPAEF IIDTRDAGYG GLSLSIEGPS KVDINTEDLE DGTCRVTYCP
2110 2120 2130 2140 2150
TEPGNYIINI KFADQHVPGS PFSVKVTGEG RVKESITRRR RAPSVANVGS
2160 2170 2180 2190 2200
HCDLSLKIPE ISIQDMTAQV TSPSGKTHEA EIVEGENHTY CIRFVPAEMG
2210 2220 2230 2240 2250
MHTVSVKYKG QHVPGSPFQF TVGPLGEGGA HKVRAGGPGL ERAEAGVPAE
2260 2270 2280 2290 2300
FGIWTREAGA GGLAIAVEGP SKAEISFEDR KDGSCGVAYV VQEPGDYEVS
2310 2320 2330 2340 2350
VKFNEEHIPD SPFVVPVASP SGDARRLTVS SLQESGLKVN QPASFAVSLN
2360 2370 2380 2390 2400
GAKGAIDAKV HSPSGALEEC YVTEIDQDKY AVRFIPRENG VYLIDVKFNG
2410 2420 2430 2440 2450
THIPGSPFKI RVGEPGHGGD PGLVSAYGAG LEGGVTGSPA EFIVNTSNAG
2460 2470 2480 2490 2500
AGALSVTIDG PSKVKMDCQE CPEGYRVTYT PMAPGSYLIS IKYGGPYHIG
2510 2520 2530 2540 2550
GSPFKAKVTG PRLVSNHSLH ETSSVFVDSL TKVATVPQHA TSGPGPADVS
2560 2570 2580 2590 2600
KVVAKGLGLS KAYVGQKSNF TVDCSKAGNN MLLVGVHGPR TPCEEILVKH
2610 2620 2630
MGSRLYSVSY LLKDKGEYTL VVKWGDEHIP GSPYRIMVP
Length:2,639
Mass (Da):280,495
Last modified:May 5, 2009 - v1
Checksum:i8A5466979F8179A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06006956 Genomic DNA. No translation available.
FJ416060 mRNA. Translation: ACN49086.1.
CH474099 Genomic DNA. Translation: EDL84989.1.
RefSeqiNP_001128071.1. NM_001134599.1.
XP_006229632.1. XM_006229570.2.
UniGeneiRn.4213.

Genome annotation databases

EnsembliENSRNOT00000068489; ENSRNOP00000062690; ENSRNOG00000037239.
GeneIDi293860.
KEGGirno:293860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06006956 Genomic DNA. No translation available.
FJ416060 mRNA. Translation: ACN49086.1 .
CH474099 Genomic DNA. Translation: EDL84989.1 .
RefSeqi NP_001128071.1. NM_001134599.1.
XP_006229632.1. XM_006229570.2.
UniGenei Rn.4213.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068489 ; ENSRNOP00000062690 ; ENSRNOG00000037239 .
GeneIDi 293860.
KEGGi rno:293860.

Organism-specific databases

CTDi 2316.
RGDi 1560614. Flna.

Phylogenomic databases

eggNOGi COG5069.
GeneTreei ENSGT00660000095431.
HOGENOMi HOG000044235.
KOi K04437.
OMAi VQVQDNE.
OrthoDBi EOG76T9QC.

Miscellaneous databases

NextBioi 637159.

Gene expression databases

Genevestigatori C0JPT7.

Family and domain databases

Gene3Di 1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A/C.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR11915:SF173. PTHR11915:SF173. 1 hit.
Pfami PF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view ]
SMARTi SM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiC0JPT7_RAT
AccessioniPrimary (citable) accession number: C0JPT7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3