C0JPT7 (C0JPT7_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Filamin alpha EMBL ACN49086.1

Submitted name:
Filamin, alpha (Predicted), isoform CRA_a EMBL EDL84989.1
Submitted name:
Protein Flna Ensembl ENSRNOP00000062690

Gene names

Name:	Flna RGD 1560614 Ensembl ENSRNOP00000062690 EMBL ACN49086.1
Synonyms:	Flna_predicted EMBL EDL84989.1
ORF Names:	rCG_43821 EMBL EDL84989.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2639 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Repeat SAAS SAAS001715
Ligand	Actin-binding SAAS SAAS001715
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin crosslink formation Inferred from electronic annotation. Source: Compara actin cytoskeleton reorganization Inferred from electronic annotation. Source: Compara adenylate cyclase-inhibiting dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara cilium assembly Inferred from electronic annotation. Source: Compara cytoplasmic sequestering of protein Inferred from electronic annotation. Source: Compara early endosome to late endosome transport Inferred from electronic annotation. Source: Compara epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara establishment of protein localization Inferred from electronic annotation. Source: Compara negative regulation of protein catabolic process Inferred from electronic annotation. Source: Compara negative regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of transcription factor import into nucleus Inferred from electronic annotation. Source: Compara protein localization to cell surface Inferred from electronic annotation. Source: Compara protein stabilization Inferred from electronic annotation. Source: Compara receptor clustering Inferred from electronic annotation. Source: Compara spindle assembly involved in mitosis Inferred from electronic annotation. Source: Compara
Cellular_component	Myb complex Inferred from electronic annotation. Source: Compara actin cytoskeleton Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara trans-Golgi network Inferred from electronic annotation. Source: Compara
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C0JPT7 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 8A5466979F8179A3	FASTA	2,639	280,495
	10 20 30 40 50 60 MSSSHSRSGQ SAAGASPAGG IDTRDAEMPA TEKDLAEDAP WKKIQQNTFT RWCNEHLKCV 70 80 90 100 110 120 SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR QMQLENVSVA LEFLDRESIK 130 140 150 160 170 180 LVSIDSKAIV DGNLKLILGL IWTLILHYSI SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL 190 200 210 220 230 240 PQLPITNFSR DWQSGRALGA LVDSCAPGLC PDWDSWDASK PVNNAREAMQ QADDWLGIPQ 250 260 270 280 290 300 VITPEEIVDP NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK 310 320 330 340 350 360 RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV TGTHKVTVLF 370 380 390 400 410 420 AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK TTYFEIFTAG AGIGEVEVVI 430 440 450 460 470 480 QDPTGQKGTV EPQLEARGDS TYRCSYQPTM EGVHTVHVTF AGVPIPRSPY TVTVGQACNP 490 500 510 520 530 540 TACRAVGRGL QPKGVRVKET ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF 550 560 570 580 590 600 EYYPTIPGTY TVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGI VGKSADFVVE 610 620 630 640 650 660 AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN SEDIRLSPFM 670 680 690 700 710 720 ADIREAPQDF HPDRVKARGP GLEKTGVAIN KPAEFTVDAK HAGKAPLRVQ VQDNEGHSVE 730 740 750 760 770 780 TTVKDNGNGT YSCSYVPRKP VKHTAMVSWG GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA 790 800 810 820 830 840 KTGLKAHEPT YFTVDCTEAG QGDVSIGIKC APGVVGPTEA DIDFDIIRND NDTFTVKYTP 850 860 870 880 890 900 CGAGSYTIMV LFADQATPTS PIRVKVEPSH DASKVKAEGP GLNRTGVELG KPTHFTVNAK 910 920 930 940 950 960 TAGKGKLDVQ FSGLAKGDAV RDVDIIDHHD NTYTVKYTPV QQGPVGVSVT YGGDHIPKSP 970 980 990 1000 1010 1020 FSVGVSPSLD LSKIKVSGLV DKVDVGKDQE FTVKSKGAGG QGKVASKIVS PSGAAVPCKV 1030 1040 1050 1060 1070 1080 EPGLGADNSV VRFVPREEGP YEVEVTYDGV PVPGSPFPVE AVAPTKPSKV KAFGPGLQGG 1090 1100 1110 1120 1130 1140 NAGSPARFTI DTKGAGTGGL GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF 1150 1160 1170 1180 1190 1200 ADTHIPGSPF KAHVVPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE 1210 1220 1230 1240 1250 1260 AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE PAVDTSGVQC 1270 1280 1290 1300 1310 1320 YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP SGNLTDTYVQ DCGDGTYKVE 1330 1340 1350 1360 1370 1380 YTPYEEGVHS VDVTYDGSPV PSSPFQVPVT EGCDPSRVRV HGPGIQSGTT NKPNKFTVET 1390 1400 1410 1420 1430 1440 RGAGTGGLGL AVEGPSEAKM SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV 1450 1460 1470 1480 1490 1500 PVHDVTDASK VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV 1510 1520 1530 1540 1550 1560 DNADGTQTVN YVPSREGSYS ISVLYGEEEV PRSPFKVKVL PTHDASKVKA SGPGLNTTGV 1570 1580 1590 1600 1610 1620 PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH DGTYTVAYVP DVTGRYTILI 1630 1640 1650 1660 1670 1680 KYGGDEIPFS PYRVRAVPTG DASKCTVTGA GIGPTIQIGE ETVITVDTKA AGKGKVTCTV 1690 1700 1710 1720 1730 1740 CTPDGSEVDV DVVENEDGTF DIFYTAPQPG KYVICVRFGG EHVPNSPFQV TALAGDQPTV 1750 1760 1770 1780 1790 1800 QTPLRPQQLP SQYTYPQGSQ QTWIPERPMV GVNGLDVTSL RPFDLVIPFT IKKGEITGEV 1810 1820 1830 1840 1850 1860 RMPSGKVAQP SITDNKDGTV TVRYSPSEAG LHEMDIRYDN MHIPGSPLQF YVDYVNCGHI 1870 1880 1890 1900 1910 1920 TAYGPGLTHG VVNKPATFTV NTKDAGEGGL SLAIEGPSKA EISCTDNQDG TCSVSYLPVL 1930 1940 1950 1960 1970 1980 PGDYSILVKY NDQHIPGSPF TARVTGDDSM RMSHLKVGSA ADIPINISET DLSLLTATVV 1990 2000 2010 2020 2030 2040 PPSGREEPCL LKRLRNGHVG ISFVPKETGE HLVHVKKNGQ HVASSPIPVV ISQSEIGDAS 2050 2060 2070 2080 2090 2100 RVRVSGQGLH EGHTFEPAEF IIDTRDAGYG GLSLSIEGPS KVDINTEDLE DGTCRVTYCP 2110 2120 2130 2140 2150 2160 TEPGNYIINI KFADQHVPGS PFSVKVTGEG RVKESITRRR RAPSVANVGS HCDLSLKIPE 2170 2180 2190 2200 2210 2220 ISIQDMTAQV TSPSGKTHEA EIVEGENHTY CIRFVPAEMG MHTVSVKYKG QHVPGSPFQF 2230 2240 2250 2260 2270 2280 TVGPLGEGGA HKVRAGGPGL ERAEAGVPAE FGIWTREAGA GGLAIAVEGP SKAEISFEDR 2290 2300 2310 2320 2330 2340 KDGSCGVAYV VQEPGDYEVS VKFNEEHIPD SPFVVPVASP SGDARRLTVS SLQESGLKVN 2350 2360 2370 2380 2390 2400 QPASFAVSLN GAKGAIDAKV HSPSGALEEC YVTEIDQDKY AVRFIPRENG VYLIDVKFNG 2410 2420 2430 2440 2450 2460 THIPGSPFKI RVGEPGHGGD PGLVSAYGAG LEGGVTGSPA EFIVNTSNAG AGALSVTIDG 2470 2480 2490 2500 2510 2520 PSKVKMDCQE CPEGYRVTYT PMAPGSYLIS IKYGGPYHIG GSPFKAKVTG PRLVSNHSLH 2530 2540 2550 2560 2570 2580 ETSSVFVDSL TKVATVPQHA TSGPGPADVS KVVAKGLGLS KAYVGQKSNF TVDCSKAGNN 2590 2600 2610 2620 2630 MLLVGVHGPR TPCEEILVKH MGSRLYSVSY LLKDKGEYTL VVKWGDEHIP GSPYRIMVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000062690.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL84989.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL84989.1.
[4]	"A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A." Carabalona A., Beguin S., Pallesi-Pocachard E., Buhler E., Pellegrino C., Arnaud K., Hubert P., Oualha M., Siffroi J.P., Khantane S., Coupry I., Goizet C., Gelot A.B., Represa A., Cardoso C. Hum. Mol. Genet. 21:1004-1017(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL ACN49086.1.
[5]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000062690.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06006956 Genomic DNA. No translation available. FJ416060 mRNA. Translation: ACN49086.1. CH474099 Genomic DNA. Translation: EDL84989.1.
IPI	IPI00951791.
RefSeq	NP_001128071.1. NM_001134599.1.
UniGene	Rn.4213.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	C0JPT7. 1 interaction.
STRING	10116.ENSRNOP00000008910.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000068489; ENSRNOP00000062690; ENSRNOG00000037239.
GeneID	293860.
KEGG	rno:293860.
Organism-specific databases
CTD	2316.
RGD	1560614. Flna.
Phylogenomic databases
eggNOG	COG5069.
GeneTree	ENSGT00660000095431.
HOGENOM	HOG000044235.
KO	K04437.
Gene expression databases
Genevestigator	C0JPT7.
Family and domain databases
Gene3D	1.10.418.10. 2 hits. 2.60.40.10. 24 hits.
InterPro	IPR001589. Actinin_actin-bd_CS. IPR001715. CH-domain. IPR001298. Filamin. IPR017868. Filamin/ABP280_repeat-like. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. [Graphical view]
Pfam	PF00307. CH. 2 hits. PF00630. Filamin. 23 hits. [Graphical view]
SMART	SM00033. CH. 2 hits. SM00557. IG_FLMN. 24 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF81296. Ig_E-set. 24 hits.
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS50194. FILAMIN_REPEAT. 24 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	637159.

Entry information

Entry name

C0JPT7_RAT

Accession

Primary (citable) accession number: C0JPT7

Entry history

Integrated into UniProtKB/TrEMBL:	May 5, 2009
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)