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Protein

Trypsin delta

Gene

deltaTry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Charge relay systemPROSITE-ProRule annotation1
Active sitei116Charge relay systemPROSITE-ProRule annotation1
Active sitei210Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin deltaImported (EC:3.4.21.4PROSITE-ProRule annotation)
Gene namesi
Name:deltaTryImported
ORF Names:CG12351Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010358. deltaTry.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22CuratedAdd BLAST22
PropeptideiPRO_000002826923 – 30Activation peptide8
ChainiPRO_000002827031 – 253Trypsin deltaSequence analysisAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
Disulfide bondi180 ↔ 197PROSITE-ProRule annotation
Disulfide bondi206 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Expressioni

Gene expression databases

BgeeiFBgn0010358.
ExpressionAtlasiC0HKA2. differential.

Structurei

3D structure databases

SMRiC0HKA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 253Peptidase S1PROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01312.
OMAiYSNNIIV.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0HKA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFVILLSA VACALGGTVP EGLLPQLDGR IVGGSATTIS SFPWQISLQR
60 70 80 90 100
SGSHSCGGSI YSSNVIVTAA HCLQSVSASV LQIRAGSSYW SSGGVTFSVS
110 120 130 140 150
SFKNHEGYNA NTMVNDIAII KINGALTFSS TIKAIGLASS NPANGAAASV
160 170 180 190 200
SGWGTLSYGS SSIPSQLQYV NVNIVSQSQC ASSTYGYGSQ IRSTMICAAA
210 220 230 240 250
SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA DVAALRSWVI

SNA
Length:253
Mass (Da):25,680
Last modified:February 15, 2017 - v1
Checksum:iF77D47E0CCC78F92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118A → V in AAA17449 (PubMed:10486967).Curated1
Sequence conflicti148A → G in AAA17449 (PubMed:10486967).Curated1
Sequence conflicti240A → S in AAA17449 (PubMed:10486967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA. Translation: AAA17449.1.
AE013599 Genomic DNA. Translation: AAF58657.2.
BT132779 mRNA. Translation: AET62584.1.
RefSeqiNP_523694.2. NM_078970.4.
NP_725034.1. NM_165823.3.
NP_725035.1. NM_165824.3.
UniGeneiDm.14041.
Dm.21711.
Dm.30904.

Genome annotation databases

EnsemblMetazoaiFBtr0088123; FBpp0087224; FBgn0050031.
FBtr0088124; FBpp0087225; FBgn0010358.
FBtr0088159; FBpp0087255; FBgn0010359.
GeneIDi246404.
36221.
48343.
KEGGidme:Dmel_CG12351.
dme:Dmel_CG30028.
dme:Dmel_CG30031.

Similar proteinsi

Entry informationi

Entry nameiTRYDT_DROME
AccessioniPrimary (citable) accession number: C0HKA2
Secondary accession number(s): G7H855
, P42276, P42277, Q8SXZ4, Q9V5Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: February 15, 2017
Last modified: September 27, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families