Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Laccase

Gene
N/A
Organism
Phellinus igniarius (Willow bracket) (Boletus igniarius)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products. Has highest activity for ABTS but can also act on guaiacol, catechol and hydroquinone with decreasing activity.1 Publication

Miscellaneous

Inhibits cell proliferation of HepG2 hepatoma cell line with an IC50 of 2.6 µM and L1210 mouse leukemia cell line with an IC50=3.2 µM respectively.1 Publication

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.1 Publication

Kineticsi

  1. KM=1.31 mM for ABTS1 Publication

    pH dependencei

    Optimum pH is 2.4.1 Publication

    Temperature dependencei

    Optimum temperature is 20 degrees Celsius.1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionOxidoreductase
    Biological processLignin degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase1 Publication (EC:1.10.3.21 Publication)
    OrganismiPhellinus igniarius (Willow bracket) (Boletus igniarius)
    Taxonomic identifieri40472 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesHymenochaetalesHymenochaetaceaePhellinus

    Subcellular locationi

    • Secretedextracellular space 1 Publication

    GO - Cellular componenti

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00004221261 – ›8Laccase›8

    Sequencei

    Sequence statusi: Fragment.

    Length:8
    Mass (Da):799
    Last modified:May 1, 2013 - v1
    Checksum:i87CB1AB2D768705D
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Non-terminal residuei81 Publication1

    Cross-referencesi

    3D structure databases

    ModBaseiSearch...
    MobiDBiSearch...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Family and domain databases

    ProtoNetiSearch...

    Entry informationi

    Entry nameiLAC_PHEIG
    AccessioniPrimary (citable) accession number: C0HJB2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
    Last sequence update: May 1, 2013
    Last modified: January 7, 2015
    This is version 6 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing