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Protein

Alpha-conotoxin-like RgIB

Gene
N/A
Organism
Conus regius (Crown cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Is a specific blocker of the alpha-3/beta-4 nAChR and may also block alpha-3/beta-4/alpha-5 channels. Causes hyperactivity and behavioral disorders in mice following intracranial injection.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like RgIB1 Publication
Short name:
Alpha-RGIB1 Publication
OrganismiConus regius (Crown cone)
Taxonomic identifieri101314 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004218541 – 23Alpha-conotoxin-like RgIB1 PublicationAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 11By similarity
Disulfide bondi6 ↔ 19By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Sequence analysis

Sequencei

Sequence statusi: Complete.

C0HJA8-1 [UniParc]FASTAAdd to basket

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        10         20 
TWEECCKNPG CRNNHVDRCR GQV
Length:23
Mass (Da):2,705
Last modified:April 3, 2013 - v1
Checksum:i955CA7844CC863A8
GO

Mass spectrometryi

Molecular mass is 2703.86±1 Da from positions 1 - 23. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiCAL1B_CONRE
AccessioniPrimary (citable) accession number: C0HJA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: April 3, 2013
Last modified: November 22, 2017
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families