Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C0HB46

- UBP12_SALSA

UniProt

C0HB46 - UBP12_SALSA

Protein

Ubiquitin carboxyl-terminal hydrolase 12

Gene

usp12

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481NucleophilePROSITE-ProRule annotation
    Active sitei319 – 3191Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. protein deubiquitination Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 12 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 12
    Ubiquitin thioesterase 12
    Ubiquitin-specific-processing protease 12
    Gene namesi
    Name:usp12
    OrganismiSalmo salar (Atlantic salmon)
    Taxonomic identifieri8030 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Ubiquitin carboxyl-terminal hydrolase 12PRO_0000378992Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 371333USPAdd
    BLAST

    Sequence similaritiesi

    Contains 1 USP domain.Curated

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0HB46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEILMTVSKF ASFCTMGANA SALEKEIGSE QFPVNEHYFG LVNFGNTCYC    50
    NSVLQALYFC RPFREKILAY RSQPRRKENL LTCLADLFHS IANQKRKVGV 100
    IPPKKFITRL RKENELFDNY MQQDAHEFLN YLLNTIADLL QEERKQDKTN 150
    GRLANGSLDS QNHNSNAPPP STWVHEIFQG TLTNETRCLT CETISSKDED 200
    FLDLSVDVEQ NTSITHCLRG FSNTETLCSE YKYYCEECRS KQEAHKRMRV 250
    KKLPMILALH LKRFKYMEQL QRYTKLSYRV VFPLELRLFN TSGDATNPER 300
    LYDLVAVVVH CGSGPNRGHY IAIVKSHDFW LLFDDDIVEK IDAQAIEEFY 350
    GLTSEISKNS ESGYILFYQS RD 372
    Length:372
    Mass (Da):43,117
    Last modified:May 5, 2009 - v1
    Checksum:i0C3294DF7CEC4C18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631H → N in ACI33173. (PubMed:20433749)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT044911 mRNA. Translation: ACI33173.1.
    BT059552 mRNA. Translation: ACN11265.1.
    RefSeqiNP_001133405.1. NM_001139933.1.
    UniGeneiSsa.17383.

    Genome annotation databases

    GeneIDi100194904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT044911 mRNA. Translation: ACI33173.1 .
    BT059552 mRNA. Translation: ACN11265.1 .
    RefSeqi NP_001133405.1. NM_001139933.1.
    UniGenei Ssa.17383.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100194904.

    Organism-specific databases

    CTDi 100194904.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome."
      Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M., Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S., Koop B.F.
      BMC Genomics 11:279-279(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiUBP12_SALSA
    AccessioniPrimary (citable) accession number: C0HB46
    Secondary accession number(s): B5X1J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3