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Protein

Probable ATP-dependent helicase PF08_0048

Gene

PF08_0048

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a chromatin remodeling complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi687 – 694ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: GeneDB
  • ATP-dependent helicase activity Source: GeneDB
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent helicase PF08_0048 (EC:3.6.4.-)
Gene namesi
ORF Names:PF08_0048
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0820000.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Biotechnological usei

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003887521 – 2082Probable ATP-dependent helicase PF08_0048Add BLAST2082

Proteomic databases

PRIDEiC0H4W3.

Expressioni

Keywords - Developmental stagei

Merozoite

Interactioni

Subunit structurei

Component of a chromatin-remodeling complex.By similarity

Protein-protein interaction databases

BioGridi1210343. 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliC0H4W3.
SMRiC0H4W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 138HSAPROSITE-ProRule annotationAdd BLAST73
Domaini674 – 839Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1772 – 1922Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili476 – 531Sequence analysisAdd BLAST56
Coiled coili1972 – 2060Sequence analysisAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi790 – 793DEAH boxSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 187Lys-richSequence analysisAdd BLAST152
Compositional biasi1025 – 1366Asn-richSequence analysisAdd BLAST342

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiC0H4W3.
OMAiELYDNNH.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.

Sequencei

Sequence statusi: Complete.

C0H4W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEIKSESLL QTRPFKLGIE DIQNLGSSYF IENNEKLKKY NNEISSLKKE
60 70 80 90 100
LDILNEKMGK CTTTTKIVEP AKTPEFTFWY YELKEMKGFQ DLVMYEVKKK
110 120 130 140 150
KKHFKVLSHS CLKYLSNREK MKIKKQEEEE KRLKLYSKNI SSYMDVFWKK
160 170 180 190 200
IEKLVWEEKK RELQQTLNKK KEMRFKKFVK EAIKKIKDAR HNNAHELFEN
210 220 230 240 250
KYVSMSSNNN SEIVNNNASS VDNGDKELKE DDLTDQEEED YLLDEQMSST
260 270 280 290 300
DESENKEEEI NMLDDEANLP IEELLKRMYG FKSGEDYINF MENEDDANEE
310 320 330 340 350
NVIETSHNDE KSGDNSIGED DNNNDEKGGD NNIDEDDNNN DEKSGDNSIG
360 370 380 390 400
EDDNNNDHKS GDNNIDEDDN NNDHKSEDNS IGEDDNNNDE KGGDNNIDEN
410 420 430 440 450
DNNSDHKSED NNIDENDNNS DHQSDQEQFN HETKDDIIKN SSYEHIDNKN
460 470 480 490 500
YYNKTGEDYK SDKENYSPTR FHNKLKKEKY DEYDTKLKIE KREEENKNYE
510 520 530 540 550
KDEHEYESDN YDKEKINKKK ELILLKNDIE NDSDETSEHI KRDSRSSCQK
560 570 580 590 600
QNCEKKRRII KDEYNLRRTK IAKSKPSSDN NNSENDNNND NNNDNNNDNN
610 620 630 640 650
DDNNDDNNDD NNDDNNDDNN DDNNDDNNNE HKNDSDDNDD ILTCNMDEKH
660 670 680 690 700
LTKIPPIIKA TLRDYQHAGL HWLLYLYKNN INGILADEMG LGKTLQCISL
710 720 730 740 750
LSYLAYYFNI WGPHLVIVPT SILINWEIEL KRFCPCFKIL SYYGNQNERY
760 770 780 790 800
KKRVGWFNKD SFHICISSYS TVVKDHLVFK RKRWKYIILD EAHNIKNFNT
810 820 830 840 850
KRWNIILSLK RDNCLLITGT PLQNSLEELW SLLHFLMPNI FTSHLDFKEW
860 870 880 890 900
FSDPLNLAIE KSKIHHSKEL IDRLHTVIRP YILRRLKKNV EKEMPNKYEH
910 920 930 940 950
IIKCKLTRRQ QILYDEFINN KNVQNTLNTG NYIGLMNILI QLRKVCNHCD
960 970 980 990 1000
LFTNKYIQTP YYYMLSIRYF VPRFFILFEK NYYADFYLIL FLHNEFTSLG
1010 1020 1030 1040 1050
GRDVTKETSP SSKSFDLAHI LTKHNTNELY DNNHISELYD NNHISELYDN
1060 1070 1080 1090 1100
NHISELYDNN HISELYDNPM SHKNYKHNSN GYTYPNDPIN NMNNNPSGFT
1110 1120 1130 1140 1150
KTSEQFGQIV SHERDNNYHM MDHNNMNNLL SKEMVNSLRN DDNSNNNFYK
1160 1170 1180 1190 1200
YSLTSNNNDS QTSIHDNKQC DYNKLCADTF NNINSIGNEE KRSLNVLNEQ
1210 1220 1230 1240 1250
NNNNSKDNNN NIDNNNNIDN NNNIDNNNNI DNNNNIDNNN NNIDNNNNID
1260 1270 1280 1290 1300
NHHNNNQHCN YNDNWPSDYP TNIINHRNAF LSILKLLNQS NPLNNDNNNN
1310 1320 1330 1340 1350
NNNNNGNNNI YNMNRYNSRN SRNSSLSNIF SSNTSKMNSF QLDFLYTNSF
1360 1370 1380 1390 1400
INQDALCKNS FFVNINIEDV HSYIYNSIYK EYIPKNILSF SDEFLTELNN
1410 1420 1430 1440 1450
NYDILSLYID PYNRYKSYNE YLYKMKEEGT LTNQQSLGDI NNKHIYHKST
1460 1470 1480 1490 1500
SNENTHMKNR KTFIYKYNNM FKVINNDTQY QNIFTDDTNN SYYNSLEHNL
1510 1520 1530 1540 1550
WIKRNQIDER KKEEEEEQNK YYNVCMNNLY ILRNERIPIF GKNFLDLIKK
1560 1570 1580 1590 1600
EFTKDKNIVY NYTNNVPIDY YSSVKEVWVE DICEKDNKKR KCKREKRWYK
1610 1620 1630 1640 1650
KIKKTNNPPE DSEVYRENSS DVEKYNCDVE KDNCDDEEKD NCDDEDMNSN
1660 1670 1680 1690 1700
LSSNVYGCID ISSQNFIHSR YHNPMMNMSY IIEFLFPNME QFLKRHEKMI
1710 1720 1730 1740 1750
HNFTLINNPS VICKSHDIRI NNNLLNYSND KMNPIILQIK NATRVYHDAF
1760 1770 1780 1790 1800
LKQSIIFPLN KDISLGSGKL CALEKLLSKC KREGNKCLLF TQFIKMLDIL
1810 1820 1830 1840 1850
EIFLNHLNYS FIRLDGSTKV EQRQKIVTKF NNDKSIFIFI SSTRSGSIGI
1860 1870 1880 1890 1900
NLTAANVVIF YDTDWNPSID KQAMDRCHRI GQTKDVHVFR FVCEYTVEEN
1910 1920 1930 1940 1950
IWKKQLQKRK LDNICINMGN FNNSNTHSKI TDTDPTHNKD WFTNVDTIKE
1960 1970 1980 1990 2000
VFINKKNNDD DDDMYKDRLL HEQVENKDKM NVRFEKTLEH VEDKDDIRAL
2010 2020 2030 2040 2050
NETKKETQNE ISQNMQEFTT RNDFQDSYNL TSYCFNFLNE NLTDSLKQQI
2060 2070 2080
DEMRMKIEIE MMNTGDENMS LSDLSNKSHN SE
Length:2,082
Mass (Da):246,748
Last modified:May 5, 2009 - v1
Checksum:i253B2FB6DDCFD602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA. Translation: CAX64141.1.
RefSeqiXP_002808863.1. XM_002808817.1.

Genome annotation databases

EnsemblProtistsiCAX64141; CAX64141; PF3D7_0820000.
GeneDBiPF3D7_0820000.1:pep.
GeneIDi2655499.
KEGGipfa:PF08_0048.

Similar proteinsi

Entry informationi

Entry nameiHEPF1_PLAF7
AccessioniPrimary (citable) accession number: C0H4W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families