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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

DealDRAFT_2355

Organism
Dethiobacter alkaliphilus AHT 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (DealDRAFT_2355)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (DealDRAFT_2355)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotationImported, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

BioCyciDALK555088:G10TA-2383-MONOMER.
UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
ORF Names:DealDRAFT_2355Imported
OrganismiDethiobacter alkaliphilus AHT 1Imported
Taxonomic identifieri555088 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeDethiobacter
Proteomesi
  • UP000006443 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi555088.DealDRAFT_2355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 175FlavoproteinInterPro annotationAdd BLAST171
Domaini186 – 365DFPInterPro annotationAdd BLAST180

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
OrthoDBiPOG091H021V.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR035929. CoaB-like_sf.
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR036551. Flavin_trans-like.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

C0GIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDKTIILG VTGGIAAYKA AELCRLFVKA GANVRVVMTD SAKQFVTPLT
60 70 80 90 100
FQTVSGNRVY DDLFTASQLY SVEHVGLAQN ADLFVIAPAT ANCIGKAAAG
110 120 130 140 150
IADDLLTTTV LAATCPVIFA PAMNTQMYEN TITQQNIAKL IEAGYHFAEP
160 170 180 190 200
EAGELACGDS GRGRMASPAA IFNQACALLG PKNKYQGLHM VVTAGPTQEP
210 220 230 240 250
LDPVRYFTNH SSGKMGFAIA RAAAEQGADV TLVSGPVNLT PPPGVELIRV
260 270 280 290 300
TTAEEMYRAV MDAYPKADLV IKAAAVADYR PATVHGQKMK KGGEMAIPLV
310 320 330 340 350
RNPDILAELG KKKENQILVG FAAETENLQE NATGKLDRKN LDMIVANDLT
360 370 380 390
MAGAGFKADT NIVRLYFRDG TEKELPLMTK DEVARQILHE ATQLLTKQ
Length:398
Mass (Da):42,562
Last modified:May 5, 2009 - v1
Checksum:iB01C24A01014FBD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACJM01000013 Genomic DNA. Translation: EEG76710.1.
RefSeqiWP_008517661.1. NZ_ACJM01000013.1.

Genome annotation databases

EnsemblBacteriaiEEG76710; EEG76710; DealDRAFT_2355.

Similar proteinsi

Entry informationi

Entry nameiC0GIP6_9FIRM
AccessioniPrimary (citable) accession number: C0GIP6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 25, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported