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Protein

Trans-2-enoyl-CoA reductase [NADH]

Gene

fabV

Organism
Blautia hydrogenotrophica DSM 10507
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).UniRule annotation

Catalytic activityi

Acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei74Plays an important role in discriminating NADH against NADPHUniRule annotation1
Binding sitei222SubstrateUniRule annotation1
Active sitei232Proton donorUniRule annotation1
Binding sitei241NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 52NADUniRule annotation6
Nucleotide bindingi73 – 74NADUniRule annotation2
Nucleotide bindingi110 – 111NADUniRule annotation2
Nucleotide bindingi138 – 139NADUniRule annotation2
Nucleotide bindingi268 – 270NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2-enoyl-CoA reductase [NADH]UniRule annotation (EC:1.3.1.44UniRule annotation)
Short name:
TERUniRule annotation
Gene namesi
Name:fabVUniRule annotation
ORF Names:RUMHYD_00930Imported
OrganismiBlautia hydrogenotrophica DSM 10507Imported
Taxonomic identifieri476272 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeBlautia
Proteomesi
  • UP000003100 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Monomer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi476272.RUMHYD_00930.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 311Enoyl_reductaseInterPro annotationAdd BLAST231
Domaini318 – 381Eno-Rase_FAD_bdInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the TER reductase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105RKW. Bacteria.
COG3007. LUCA.
OrthoDBiPOG091H03HI.

Family and domain databases

HAMAPiMF_01838. FabV_reductase. 1 hit.
InterProiView protein in InterPro
IPR024906. Eno_Rdtase_FAD-bd_dom.
IPR024910. Enoyl-CoA_Rdtase_cat_dom.
IPR010758. Trans-2-enoyl-CoA_reductase.
PfamiView protein in Pfam
PF07055. Eno-Rase_FAD_bd. 1 hit.
PF12242. Eno-Rase_NADH_b. 1 hit.
PF12241. Enoyl_reductase. 1 hit.

Sequencei

Sequence statusi: Complete.

C0CJB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVEPKVREY ICTTAHPAGC EENVREQIAY VKAQGPKAGP KKVLVIGAST
60 70 80 90 100
GYGLASRITA AFGCQAATLG IMFERPASGK RTATAGWYNT AAFEKFATQD
110 120 130 140 150
GLYAKSINGD AFSAEVKKQA IDIIRRDLGQ VDLVVYSLAA PRRSADGVTY
160 170 180 190 200
SSTLKTVGSP FTEKSIDLRT NEIVTKSVEP ATDKEIEGTI KVMGGEDWED
210 220 230 240 250
WIKVLQKAGV LAENAKTVAY SYIGPELTYP IYTHGTIGQA KNHLQKTAEK
260 270 280 290 300
MNQELNGVTA VVSVNKALVT QASSAIPIVP LYLSILYKIM KEQGSHEDCI
310 320 330 340 350
RQMDRLFRTK LLENPMPVDQ EGRIRMDDWE LDEKVQAEVM KVWAMMSTEN
360 370 380 390
LKEVSDIDGY WEDFYKMFGF RFEQVDYSQD VDVDVRIPSL EEN
Length:393
Mass (Da):43,700
Last modified:May 5, 2009 - v1
Checksum:iD21D51EEF96039A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACBZ01000040 Genomic DNA. Translation: EEG50160.1.
RefSeqiWP_005946544.1. NZ_GG657679.1.

Genome annotation databases

EnsemblBacteriaiEEG50160; EEG50160; RUMHYD_00930.
PATRICifig|476272.21.peg.3941.

Similar proteinsi

Entry informationi

Entry nameiC0CJB2_9FIRM
AccessioniPrimary (citable) accession number: C0CJB2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 7, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported