C0AL79 (C0AL79_BORBU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
S-ribosylhomocysteine lyase HAMAP MF_00091
EC=4.4.1.21 HAMAP MF_00091

Alternative name(s):
AI-2 synthesis protein HAMAP MF_00091
Autoinducer-2 production protein LuxS HAMAP MF_00091

Gene names

Name:	luxS HAMAP MF_00091 EMBL EEG99850.1
ORF Names:	BBU94A_0379 EMBL EEG99850.1

Organism

Borrelia burgdorferi 94a EMBL EEG99850.1

Taxonomic identifier

476212 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP MF_00091 SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091 SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. HAMAP MF_00091 SAAS SAAS003815
Subunit structure	Homodimer By similarity. HAMAP MF_00091 SAAS SAAS003815
Sequence similarities	Belongs to the LuxS family. HAMAP MF_00091

Ontologies

Keywords
Biological process	Autoinducer synthesis HAMAP MF_00091 SAAS SAAS003815 Quorum sensing HAMAP MF_00091 SAAS SAAS003815
Ligand	Iron HAMAP MF_00091 SAAS SAAS003815 Metal-binding HAMAP MF_00091 SAAS SAAS003815
Molecular function	Lyase HAMAP MF_00091 SAAS SAAS003815
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: HAMAP
Molecular function	S-ribosylhomocysteine lyase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	53	1	Iron By similarity HAMAP MF_00091
	Metal binding	57	1	Iron By similarity HAMAP MF_00091
	Metal binding	124	1	Iron By similarity HAMAP MF_00091

Sequences

	Sequence		Length	Mass (Da)
	C0AL79 [UniParc]. Last modified May 5, 2009. Version 1. Checksum: 89C3844C37BB7504	FASTA	157	18,098
	10 20 30 40 50 60 MKKITSFTID HTKLNPGIYV SRKDTFENVI FTTIDIRIKA PNIEPIIENA AIHTIEHIGA 70 80 90 100 110 120 TLLRNNEVWT EKIVYFGPMG CRTGFYLIIF GDYESKDLVD LVSWLFSEIV NFSEPIPGAS 130 140 150 DKECGNYKEH NLDMAKYESS KYLQILNNIK EENLKYP

References

[1]	Fraser-Liggett C.M., Mongodin E.F., Casjens B., Dunn J., Luft B., Qiu W., Schutzer S., Sebastian Y. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 94a EMBL EEG99850.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABGK02000005 Genomic DNA. Translation: EEG99850.1.
3D structure databases
ProteinModelPortal	C0AL79.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	29196462. VBIBorBur118286_1036.
Phylogenomic databases
OMA	TTFDIRM.
Family and domain databases
HAMAP	MF_00091. LuxS. [Tree]
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C0AL79_BORBU

Accession

Primary (citable) accession number: C0AL79

Entry history

Integrated into UniProtKB/TrEMBL:	May 5, 2009
Last sequence update:	May 5, 2009
Last modified:	December 14, 2011
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)