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Protein

DNA polymerase I

Gene

polA

Organism
Borreliella spielmanii A14S
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, DNA-directed DNA polymeraseUniRule annotation, Hydrolase, NucleaseSAAS annotation, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repairUniRule annotation, DNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:polAUniRule annotationImported
ORF Names:BSPA14S_0557Imported
OrganismiBorreliella spielmanii A14SImported
Taxonomic identifieri498742 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000003481 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi498742.BSPA14S_0557.

Structurei

3D structure databases

ProteinModelPortaliB9X8G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 25953EXOcInterPro annotationAdd BLAST259
Domaini321 – 5003'-5' exonucleaseInterPro annotationAdd BLAST180
Domaini666 – 872POLAcInterPro annotationAdd BLAST207

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
OrthoDBiPOG091H00PR.

Family and domain databases

CDDicd09898. H3TH_53EXO. 1 hit.
Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR036279. 5-3_exonuclease_C_sf.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR020045. DNA_polI_H3TH.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN-like_dom_sf.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PANTHERiPTHR10133. PTHR10133. 1 hit.
PfamiView protein in Pfam
PF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
PF01612. DNA_pol_A_exo1. 1 hit.
PRINTSiPR00868. DNAPOLI.
SMARTiView protein in SMART
SM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiView protein in PROSITE
PS00447. DNA_POLYMERASE_A. 1 hit.

Sequencei

Sequence statusi: Complete.

B9X8G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELYLIDAL NIIFRNYHVM KNYPLLNTQG ENVNAFVGFF KTLFFIIKEK
60 70 80 90 100
NPKHLIITFD SEIPTFRKQK YPNYKATRDA PPDDLIPQIG WIKKGLLKAK
110 120 130 140 150
IPIFEIEGYE ADDLLASFAK KATQNNYLTY IISPDKDLLQ IMSEHIKILK
160 170 180 190 200
IENNRFVEMD NEYVIKKFGI NSFQIKDYLA IVGDRSDNIP GIKGIGPKGA
210 220 230 240 250
ANLLREFKTL KGIYSNLELI TKKHQEILIK EKENAFLSYD LVSLEENLKI
260 270 280 290 300
PEIENFALKN FSEEIISLFE KHSAITLIKT YKRDILKQEE ENLAQKSLFK
310 320 330 340 350
QESTTKSIDT LNTIDTENVK YHSITTKKEL DNLIESLKKA KYISIDTETS
360 370 380 390 400
SLDIYTARLI GISISFKEFE GYYIPIEARG KIYIEKHYII QKFNNFFESN
410 420 430 440 450
PKIIGQNYKF DYKILKNNGF NPIPPYFDTM IAAYLIDTNS KVSLDFLAEK
460 470 480 490 500
YLMHKNIKYE DVIQKNDNFA GISLEMATSY SSEDADITFR LFNVFSKKLK
510 520 530 540 550
EDSLDKLMHE IEMPFNNVII EMEENGIYLD REYLKEYGKE LGKELELIET
560 570 580 590 600
EIIKSIGIDF NLNSPKQMHE ILFEKLNLKL PEKMKKDSTD IKVLESLRGQ
610 620 630 640 650
HESIENLIKH RQIAKLKSTY TDNLIELINY KTNRLHTNFI QTKTATGRVT
660 670 680 690 700
SINPNLQNIP IKDEKGRKIR KAFKPENGNI FISADYSQIE LAILAHLSQD
710 720 730 740 750
EVLIKAFENN KDIHTETASK LFKIEEKEIT PNLRRIAKSI NFGIIYRMSD
760 770 780 790 800
FRLAKELGIT KEEAKGFIDS YFDSYPKIKE FIINQINFVR NTGYSETILK
810 820 830 840 850
RRRYIKEINS NNYLERSAAE RISINSIIQG SAADIMKIAM VKVFNEFKSK
860 870 880 890 900
KMESKILLQV HDEMLIESPI KEENEVKKIL KIMMETAYTL TPPLRANIET

GKSWGEIH
Length:908
Mass (Da):105,580
Last modified:April 14, 2009 - v1
Checksum:iDE5F5BF1EBE89882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABKB02000009 Genomic DNA. Translation: EEF84232.1.
RefSeqiWP_006433865.1. NZ_ABKB02000009.1.

Genome annotation databases

EnsemblBacteriaiEEF84232; EEF84232; BSPA14S_0557.

Similar proteinsi

Entry informationi

Entry nameiB9X8G2_9SPIR
AccessioniPrimary (citable) accession number: B9X8G2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 14, 2009
Last sequence update: April 14, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported