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B9X0J1 (STBOS_STERE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Baccharis oxide synthase

Short name=StrBOS
EC=5.4.99.51
OrganismStevia rebaudiana (Stevia)
Taxonomic identifier55670 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceEupatorieaeStevia

Protein attributes

Sequence length761 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidosqualene cyclase converting (3S)-2,3-epoxy-2,3-dihydrosqualene to baccharis oxide, a triterpene with a 3,10-oxide bridge in the A-ring. Also mediates conversion of other triterpenoids at a much lower level. Ref.1

Catalytic activity

(3S)-2,3-epoxy-2,3-dihydrosqualene = baccharis oxide. Ref.1

Sequence similarities

Belongs to the terpene cyclase/mutase family.

Contains 2 PFTB repeats.

Ontologies

Keywords
   DomainRepeat
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processmetabolic process

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionoxidosqualene cyclase activity

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 761761Baccharis oxide synthase
PRO_0000418758

Regions

Repeat148 – 18942PFTB 1
Repeat639 – 68042PFTB 2

Sequences

Sequence LengthMass (Da)Tools
B9X0J1 [UniParc].

Last modified April 14, 2009. Version 1.
Checksum: 79354A8BA097B2C2

FASTA76188,050
        10         20         30         40         50         60 
MWRLKIADGN NNPYLYSTNN FVGRQTWEFD PNYGTQEERD EVEQARQHFW NNRHQFKATG 

        70         80         90        100        110        120 
DVLWRMQFIR EKRFKQTIPQ VKIEDGEEIS YDKVTATLRR SVHLLAALQA DDGHWPAENT 

       130        140        150        160        170        180 
GPMFFIQPLV ICLYITGHLD RVFPKEHKKE ILRYLYTQQN EDGGWGLHIE GQSIMFGTIM 

       190        200        210        220        230        240 
SYVCMRLLGE GPDGGLNGAC TKARKWILDH GSVLASPSWG KIYLTILGVH EWEGCNPLPP 

       250        260        270        280        290        300 
EFWILPSIFP MHPAKMWCYC RLIYMPMSYL YGRRFVGPIT PLVLQLREEL YSQSYNDIKW 

       310        320        330        340        350        360 
KSTRHLVVKE DLHYPHPWLQ DLMWDGLYIF TEPLLTRWPF SKLREKALKT TINHIHYEDE 

       370        380        390        400        410        420 
NSRYITIGAV EKSLCMLACW DEDPDGVCFK KHLARIPDYI WVSEDGLKMQ SFGSQLWDAS 

       430        440        450        460        470        480 
LAIQALLATD LNHDIEPILR KGHDFIKASQ VKDNPSGDFK SMYRHITKGS WTFSDQDHGW 

       490        500        510        520        530        540 
QTSDCTTEGL KCCLLLSKMS AEIVGEKMQP EQFYDAVNLI LSLQCKNGGE AGWEPAGESN 

       550        560        570        580        590        600 
WLEFLNPSEL FEDIVLEHDS VECTATGMQA LVIFKKLYPK HRREEIEKFL KDACGYLEKV 

       610        620        630        640        650        660 
QMQDGSWYGE WGICFTYGTC FALGGMEAIG KTYENCEAIR RAVNFLLTTQ RNDGGWGESY 

       670        680        690        700        710        720 
RSSPKKKYVP LEGNRSNLVQ TACALMGLIR SKQEERDPTP LHRAAKLLIN SQMENGDFPQ 

       730        740        750        760 
EETGGVFKKN CLLHYPMYRN IYTLWALGEY RKKVLPQPTK V 

« Hide

References

[1]"Biosynthesis of baccharis oxide, a triterpene with a 3,10-oxide bridge in the A-ring."
Shibuya M., Sagara A., Saitoh A., Kushiro T., Ebizuka Y.
Org. Lett. 10:5071-5074(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY.
Tissue: Root.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB455264 mRNA. Translation: BAH23676.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.50.10.20. 2 hits.
InterProIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 2 hits.
TIGRFAMsTIGR01787. squalene_cyclas. 1 hit.
PROSITEPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTBOS_STERE
AccessionPrimary (citable) accession number: B9X0J1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families