ID   B9WMB5_CANDC            Unreviewed;       468 AA.
AC   B9WMB5;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   OrderedLocusNames=Cd36_32740 {ECO:0000313|CGD:CAL0000165963},
GN   Cd36_33110 {ECO:0000313|CGD:CAL0000166607};
GN   ORFNames=CD36_32740 {ECO:0000313|EMBL:CAX40228.1}, CD36_33110
GN   {ECO:0000313|EMBL:CAX40261.1};
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX40228.1, ECO:0000313|Proteomes:UP000002605};
RN   [1] {ECO:0000313|EMBL:CAX40228.1, ECO:0000313|Proteomes:UP000002605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 {ECO:0000313|EMBL:CAX40228.1}, and CD36 / ATCC MYA-646 /
RC   CBS 7987 / NCPF 3949 / NRRL Y-17841
RC   {ECO:0000313|Proteomes:UP000002605};
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004888}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; FM992695; CAX40228.1; -; Genomic_DNA.
DR   EMBL; FM992695; CAX40261.1; -; Genomic_DNA.
DR   RefSeq; XP_002422224.1; XM_002422179.1.
DR   RefSeq; XP_002422257.1; XM_002422212.1.
DR   AlphaFoldDB; B9WMB5; -.
DR   GeneID; 8049373; -.
DR   GeneID; 8049406; -.
DR   KEGG; cdu:CD36_32740; -.
DR   KEGG; cdu:CD36_33110; -.
DR   CGD; CAL0000165963; Cd36_32740.
DR   CGD; CAL0000166607; Cd36_33110.
DR   VEuPathDB; FungiDB:CD36_32740; -.
DR   VEuPathDB; FungiDB:CD36_33110; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_5_0_1; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000002605; Chromosome R.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443:SF30; GLUCOKINASE-1-RELATED; 1.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          11..212
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          225..466
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   468 AA;  51772 MW;  F714EA24BFB080F8 CRC64;
     MSLSPKLEET VSSIEKAFDI KDDFLVKATE YFIESMNVGL ESPKPSKDVM PMIPTYVTSI
     PTGKEVGLYL AADLGGTNFR VCSIDLKGDH TFTMKQSKYR LPVDLMKAEK SDDLFSFLAK
     KVQSFLLEHH SEACSAKNAE PLKLGFTFSF PVNQTALDRG TLIRWTKGFD IPDAVDRDVV
     ELLQANLTVL EVNVKVVAIA NDTVGTLLTA AYSNDPEKTN RNTIIGCIFG TGTNGAYFES
     KIPKLASSKG MVINTEWGSF DNGLKILPCT EFDKIVDSET ANPGYHLFEK RISGMFLGEI
     LRVVLINLFE KGLIFQELYK ARGGSLPHRI QEPWLLDAEV LSYLQIDDST DLRMSGLILQ
     NVLRLETNKE ERVVIQRLTR AISKRAAHLS AIPIAAIAKK VKDQYKDDDR DFEVGCDGSV
     VEFYPGFRQA VLESVEKINP LKGTNKKIYL KIAKDGSGVG AALCASTA
//