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B9WJJ7

- KEX1_CANDC

UniProt

B9WJJ7 - KEX1_CANDC

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, CD36_70870
Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841 By similarity
Active sitei394 – 3941 By similarity
Active sitei452 – 4521 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CD36_70870
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000002605: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 543524Lumenal Reviewed prediction
Add
BLAST
Transmembranei544 – 56421Helical; Reviewed prediction
Add
BLAST
Topological domaini565 – 686122Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 686667Pheromone-processing carboxypeptidase KEX1
PRO_0000411909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi573826.CD36_70870.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi522 – 5309Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B9WJJ7-1 [UniParc]FASTAAdd to Basket

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MKFLLPTFII FIYTLLVSAL PTKEGSDPKA AKKYLVSDLP GLHDNITPDD    50
SIPLMFAGQL EIYPESNTHY FFWKFSDSNQ ETITNRTIFW LNGGPGCSSM 100
DGALLETGPF RINSQQQVIS NNGSWHKSGD IIYVDQPAGT GFSYSDTYIT 150
DLDQVANYFL KFMEAYYELF PQEINNEIYF AGESYAGQYI PYIANAILQR 200
NKKLHEGEQK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG LIDIHHPKWA 250
TLLAKHEQCQ KIVNKIDSTF DDGTVHYYEV SSSTCEAILT DLLEYTQDTA 300
NDKNQQCINM YDYTLRDSYP SCGMNWPNEL VNVGPFLRQE KVMHQLNLIN 350
LKKWNECNGK VGRTFQARHS IPSVHLLPEL AKEIPVMLFN GANDIICNSQ 400
GVLSYLQKLQ WNGETGFINK DNQISWVYDN KEVGYMLWER NISFINIYNS 450
SHMVPYDLPD VSRALIDLIT GEYDEKDVDG KKSFVTYPLG SRKENDESKN 500
PVESPSQTID PIISSSSSSV ESSLSSSSAS ATDSDSTSSK FTRLIQLAVI 550
LVIFWGVYVL YASYKSRPSS IIKKPTNNTS NITRSSTGKK KNVQWADQLN 600
QFEDDERNQE SNQGIIAKAI GKITGSKDTR GRYAPVHREN DNEYIDDIEL 650
GEGISDPNVD EFIIGSDDDD EEEQPRSDPA THKSVS 686
Length:686
Mass (Da):77,574
Last modified:March 24, 2009 - v1
Checksum:iD6525FC9603CA262
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM992694 Genomic DNA. Translation: CAX40641.1.
RefSeqiXP_002421307.1. XM_002421262.1.

Genome annotation databases

GeneIDi8049274.
KEGGicdu:CD36_70870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM992694 Genomic DNA. Translation: CAX40641.1 .
RefSeqi XP_002421307.1. XM_002421262.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 573826.CD36_70870.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8049274.
KEGGi cdu:CD36_70870.

Phylogenomic databases

eggNOGi COG2939.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841.

Entry informationi

Entry nameiKEX1_CANDC
AccessioniPrimary (citable) accession number: B9WJJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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