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B9WJJ7

- KEX1_CANDC

UniProt

B9WJJ7 - KEX1_CANDC

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei184 – 1841PROSITE-ProRule annotation
    Active sitei394 – 3941PROSITE-ProRule annotation
    Active sitei452 – 4521PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CD36_70870
    OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
    Taxonomic identifieri573826 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000002605: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 686667Pheromone-processing carboxypeptidase KEX1PRO_0000411909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi573826.CD36_70870.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 543524LumenalSequence AnalysisAdd
    BLAST
    Topological domaini565 – 686122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei544 – 56421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi522 – 5309Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B9WJJ7-1 [UniParc]FASTAAdd to Basket

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    MKFLLPTFII FIYTLLVSAL PTKEGSDPKA AKKYLVSDLP GLHDNITPDD    50
    SIPLMFAGQL EIYPESNTHY FFWKFSDSNQ ETITNRTIFW LNGGPGCSSM 100
    DGALLETGPF RINSQQQVIS NNGSWHKSGD IIYVDQPAGT GFSYSDTYIT 150
    DLDQVANYFL KFMEAYYELF PQEINNEIYF AGESYAGQYI PYIANAILQR 200
    NKKLHEGEQK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG LIDIHHPKWA 250
    TLLAKHEQCQ KIVNKIDSTF DDGTVHYYEV SSSTCEAILT DLLEYTQDTA 300
    NDKNQQCINM YDYTLRDSYP SCGMNWPNEL VNVGPFLRQE KVMHQLNLIN 350
    LKKWNECNGK VGRTFQARHS IPSVHLLPEL AKEIPVMLFN GANDIICNSQ 400
    GVLSYLQKLQ WNGETGFINK DNQISWVYDN KEVGYMLWER NISFINIYNS 450
    SHMVPYDLPD VSRALIDLIT GEYDEKDVDG KKSFVTYPLG SRKENDESKN 500
    PVESPSQTID PIISSSSSSV ESSLSSSSAS ATDSDSTSSK FTRLIQLAVI 550
    LVIFWGVYVL YASYKSRPSS IIKKPTNNTS NITRSSTGKK KNVQWADQLN 600
    QFEDDERNQE SNQGIIAKAI GKITGSKDTR GRYAPVHREN DNEYIDDIEL 650
    GEGISDPNVD EFIIGSDDDD EEEQPRSDPA THKSVS 686
    Length:686
    Mass (Da):77,574
    Last modified:March 24, 2009 - v1
    Checksum:iD6525FC9603CA262
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM992694 Genomic DNA. Translation: CAX40641.1.
    RefSeqiXP_002421307.1. XM_002421262.1.

    Genome annotation databases

    GeneIDi8049274.
    KEGGicdu:CD36_70870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM992694 Genomic DNA. Translation: CAX40641.1 .
    RefSeqi XP_002421307.1. XM_002421262.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 573826.CD36_70870.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8049274.
    KEGGi cdu:CD36_70870.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841.

    Entry informationi

    Entry nameiKEX1_CANDC
    AccessioniPrimary (citable) accession number: B9WJJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3