ID   B9WJF3_CANDC            Unreviewed;       494 AA.
AC   B9WJF3;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   Name=NAG5 {ECO:0000313|EMBL:CAX41376.1};
GN   OrderedLocusNames=Cd36_65510 {ECO:0000313|CGD:CAL0000171931};
GN   ORFNames=CD36_65510 {ECO:0000313|EMBL:CAX41376.1};
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826 {ECO:0000313|EMBL:CAX41376.1, ECO:0000313|Proteomes:UP000002605};
RN   [1] {ECO:0000313|EMBL:CAX41376.1, ECO:0000313|Proteomes:UP000002605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841
RC   {ECO:0000313|Proteomes:UP000002605};
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; FM992693; CAX41376.1; -; Genomic_DNA.
DR   RefSeq; XP_002421215.1; XM_002421170.1.
DR   AlphaFoldDB; B9WJF3; -.
DR   GeneID; 8048699; -.
DR   KEGG; cdu:CD36_65510; -.
DR   CGD; CAL0000171931; Cd36_65510.
DR   VEuPathDB; FungiDB:CD36_65510; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_4_1_1; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000002605; Chromosome 6.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF24; HEXOKINASE YLR446W-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          40..229
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          239..492
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   494 AA;  54855 MW;  9CFE05F0F48936C8 CRC64;
     MIETSIESVG GLTSGPMYFM EIVSSQSSVL SSIVESFTSA VSASNLGVYS EELLGDVKHS
     LRENSPITML PNYNISPTGE EHGSYLVIDL GGSTLRIAVV DISKPHPKLS RTERITIVVE
     KSWIIGNDFK RIDYEFFKYI GSKINEILVG QNVIDVNSVI NTGITWSFPL ETTNYNSGRI
     KHVSKGYTVG EDIYGKDLKT VLEETLRQEY GLALEVNSIL NDSLAVYSAG CFIDSNMKLA
     MVLGTGINMC CSLKKSSEIC RYKMLADATL FNCELSLFGQ NLCKDFATKY DSIIDQRFAR
     TQHHFKTFMG PDPLTQTLFQ PHELMTSGRY LPELTRLVVV DLIEAGEIFQ NVDCQSFYEE
     YGGFSGELMC FVHETDDYND IHVKLCKAYG WTGIGRSDVV CLKEVVSCII KRAAFIVANA
     IIAFFKLLGG DELCGDVTIG YVGSVLNYFH EYRRLIIEYV NNAAEAKQLG VTIDLKLIDN
     SSIIGAAIGA AYYR
//