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Protein

Histone-lysine N-methyltransferase

Gene

Cd36_24310

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Ordered Locus Names:Cd36_24310Imported
ORF Names:CD36_24310Imported
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)Imported
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000002605 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000171457. Cd36_24310.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi573826.XP_002418904.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 140AWSInterPro annotationAdd BLAST57
Domaini142 – 259SETInterPro annotationAdd BLAST118
Domaini266 – 282Post-SETInterPro annotationAdd BLAST17
Domaini549 – 583WWInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000248214.
KOiK11423.
OrthoDBiEOG092C3T9B.

Family and domain databases

CDDicd00201. WW. 1 hit.
Gene3Di1.20.930.10. 1 hit.
InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR035441. TFIIS/LEDGF_dom_sf.
IPR001202. WW_dom.
IPR036020. WW_dom_sf.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B9WCT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNNPQESS NNSNSPLKRS TPMLFLDAED KTQEALTTFE LLNACTYQNK
60 70 80 90 100
YVGSANVTTT TTNKTSGSTS TKSHQQQQQN RRKLEFMTCD CEEEWDSELQ
110 120 130 140 150
MNLACGPDSN CINRITCVEC INKNCLCGDD CQNQRFQNCQ YSKVKVIQTE
160 170 180 190 200
LKGYGLIAEQ DIEENQFIYE YIGEVIDESS FRQRMIEYDL RHLKHFYFMM
210 220 230 240 250
LSNDSFIDAT QKGSLGRFIN HSCNPNAFVD KWHVGDRLRM GIFAKRKILR
260 270 280 290 300
GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA
310 320 330 340 350
LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEID PIENQDGVTK
360 370 380 390 400
VMSALMKTQH PLIIKKLIER ISVSSGHDAI NVMFVRFHGY KTISTILQDL
410 420 430 440 450
LVSKNNDKES ETNDHDNNKD SIEDKDELII KILKILVTWP AVTKNKISSS
460 470 480 490 500
NLEEVVKDIQ TSNESSNNKE EINELCTSLL ERWSKLEMAY RIPKQESAIA
510 520 530 540 550
NNATAGTATT TATGTSASPF ERISSHTPEL GATNTPTSSS QQQQQSRDAG
560 570 580 590 600
LPENWRSAFD KNTGGYYYYN TVTQETTWER PLGSLPLGPK PPSGPGIKGR
610 620 630 640 650
LNKYNEIDLA KREELRIQKE KEMKFIEMQN RDRKLKELIE MSKKSMNNSA
660 670 680 690 700
NNFNGFSDNG DNNGNTNTTS TTGGVYGITS DKQGGKHHHD KHSKNGPRNT
710 720 730 740 750
SISTSTSDSG SGNIEKTWKR IFAKYIPNII KKYESEIGRD NVKGCARELV
760 770 780 790 800
NVLTQSEIKH GKKPPSNDSN MELNDKKLKK IKEYSYRYMD KFLIKFNNSK
810 820 830
KNKSITGSNG GDSDKHKRKH DDDDGNDGEN GVKRSKV
Length:837
Mass (Da):94,743
Last modified:March 24, 2009 - v1
Checksum:i157A8C2F82249E53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992689 Genomic DNA. Translation: CAX44211.1.
RefSeqiXP_002418904.1. XM_002418859.1.

Genome annotation databases

EnsemblFungiiCAX44211; CAX44211; CD36_24310.
GeneIDi8046508.
KEGGicdu:CD36_24310.

Similar proteinsi

Entry informationi

Entry nameiB9WCT7_CANDC
AccessioniPrimary (citable) accession number: B9WCT7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported