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B9WBP0

- B9WBP0_CANDC

UniProt

B9WBP0 - B9WBP0_CANDC

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Protein

Isocitrate dehydrogenase [NADP]

Gene

CD36_20310

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061SubstrateUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Sitei168 – 1681Critical for catalysisUniRule annotation
Sitei240 – 2401Critical for catalysisUniRule annotation
Metal bindingi280 – 2801Magnesium or manganeseUniRule annotation
Metal bindingi303 – 3031Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:CD36_20310Imported
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)Imported
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000002605: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi573826.CD36_20310.

Structurei

3D structure databases

ProteinModelPortaliB9WBP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1297Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9WBP0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRTTTTRTI NRTAMLSKHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI
60 70 80 90 100
IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV
110 120 130 140 150
KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI
160 170 180 190 200
PGWKEPIVIG RHAFGDQYKA TDLVITEPGK LELRFTPASG GETQTHKVYD
210 220 230 240 250
YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR
260 270 280 290 300
FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY
310 320 330 340 350
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG
360 370 380 390 400
KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFANTLEKA TIDTVEVDRI
410 420 430
MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK
Length:433
Mass (Da):48,466
Last modified:March 24, 2009 - v1
Checksum:i8F5244366E04E46C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992689 Genomic DNA. Translation: CAX43811.1.
RefSeqiXP_002418510.1. XM_002418465.1.

Genome annotation databases

GeneIDi8046058.
KEGGicdu:CD36_20310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992689 Genomic DNA. Translation: CAX43811.1 .
RefSeqi XP_002418510.1. XM_002418465.1.

3D structure databases

ProteinModelPortali B9WBP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 573826.CD36_20310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8046058.
KEGGi cdu:CD36_20310.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841Imported.

Entry informationi

Entry nameiB9WBP0_CANDC
AccessioniPrimary (citable) accession number: B9WBP0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3