B9WBP0 (B9WBP0_CANDC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108

Gene names

ORF Names:

CD36_20310 EMBL CAX43811.1

Organism

Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast) [Complete proteome]

Taxonomic identifier

573826 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida dubliniensis

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle PIRNR PIRNR000108
Ligand	Magnesium PIRNR PIRNR000108 PIRSR PIRSR000108-3 Manganese PIRNR PIRNR000108 PIRSR PIRSR000108-3 Metal-binding PIRNR PIRNR000108 PIRSR PIRSR000108-3 NADP PIRNR PIRNR000108 PIRSR PIRSR000108-4
Molecular function	Oxidoreductase PIRNR PIRNR000108 RuleBase RU004444 EMBL CAX43811.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isocitrate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	104 – 106	3	NADP By similarity PIRSR PIRSR000108-4
	Nucleotide binding	338 – 343	6	NADP By similarity PIRSR PIRSR000108-4
	Region	123 – 129	7	Substrate binding By similarity PIRSR PIRSR000108-2
Sites
	Metal binding	280	1	Magnesium or manganese By similarity PIRSR PIRSR000108-3
	Metal binding	303	1	Magnesium or manganese By similarity PIRSR PIRSR000108-3
	Binding site	106	1	Substrate By similarity PIRSR PIRSR000108-2
	Binding site	111	1	NADP By similarity PIRSR PIRSR000108-4
	Binding site	138	1	Substrate By similarity PIRSR PIRSR000108-2
	Binding site	161	1	Substrate By similarity PIRSR PIRSR000108-2
	Binding site	288	1	NADP By similarity PIRSR PIRSR000108-4
	Binding site	356	1	NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
	Site	168	1	Critical for catalysis By similarity PIRSR PIRSR000108-1
	Site	240	1	Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

	Sequence		Length	Mass (Da)
	B9WBP0 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 8F5244366E04E46C	FASTA	433	48,466
	10 20 30 40 50 60 MIRTTTTRTI NRTAMLSKHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI IWQKIKDQLI 70 80 90 100 110 120 LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV KCATITPDEA RVKEFNLKKM 130 140 150 160 170 180 WLSPNGTIRN ILGGTVFRES IIIPCIPRLI PGWKEPIVIG RHAFGDQYKA TDLVITEPGK 190 200 210 220 230 240 LELRFTPASG GETQTHKVYD YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK 250 260 270 280 290 300 NTILKKYDGR FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY 310 320 330 340 350 360 DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG KETSTNSIAS 370 380 390 400 410 420 IFAWTRGLAQ RGRLDETPEV VDFANTLEKA TIDTVEVDRI MTKDLALAMG KTDRSAYVTT 430 TEFLDAVADR LKK

References

[1]

"Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans." Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D., Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C., de Groot P.W., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A., Pain A., Poulter R.T. , Rajandream M.A., Renauld H., Spiering M.J., Tivey A., Gow N.A., Barrell B., Sullivan D.J., Berriman M. Genome Res. 19:2231-2244(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM992689 Genomic DNA. Translation: CAX43811.1.
RefSeq	XP_002418510.1. XM_002418465.1.
3D structure databases
ProteinModelPortal	B9WBP0.
ModBase	Search...
Protein-protein interaction databases
STRING	573826.CD36_20310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8046058.
KEGG	cdu:CD36_20310.
Phylogenomic databases
eggNOG	COG0538.
HOGENOM	HOG000019858.
KO	K00031.
OrthoDB	EOG47M56G.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR004790. Isocitrate_DH_NADP. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11822. PTHR11822. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMs	TIGR00127. nadp_idh_euk. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9WBP0_CANDC

Accession

Primary (citable) accession number: B9WBP0

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	April 3, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)