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Protein

Isocitrate dehydrogenase [NADP]

Gene

Cd36_20310

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateUniRule annotation1
Binding sitei111NADPUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Sitei168Critical for catalysisUniRule annotation1
Sitei240Critical for catalysisUniRule annotation1
Metal bindingi280Magnesium or manganeseUniRule annotation1
Binding sitei288NADPUniRule annotation1
Metal bindingi303Magnesium or manganeseUniRule annotation1
Binding sitei356NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 106NADPUniRule annotation3
Nucleotide bindingi338 – 343NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Cd36_20310Imported
ORF Names:CD36_20310Imported
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)Imported
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000002605 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000162212. Cd36_20310.

Interactioni

Protein-protein interaction databases

STRINGi573826.XP_002418510.1.

Structurei

3D structure databases

ProteinModelPortaliB9WBP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 427Iso_dhInterPro annotationAdd BLAST390

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni123 – 129Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
HOGENOMiHOG000019858.
KOiK00031.
OrthoDBiEOG092C2D51.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9WBP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTTTTRTI NRTAMLSKHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI
60 70 80 90 100
IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV
110 120 130 140 150
KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI
160 170 180 190 200
PGWKEPIVIG RHAFGDQYKA TDLVITEPGK LELRFTPASG GETQTHKVYD
210 220 230 240 250
YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR
260 270 280 290 300
FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY
310 320 330 340 350
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG
360 370 380 390 400
KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFANTLEKA TIDTVEVDRI
410 420 430
MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK
Length:433
Mass (Da):48,466
Last modified:March 24, 2009 - v1
Checksum:i8F5244366E04E46C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992689 Genomic DNA. Translation: CAX43811.1.
RefSeqiXP_002418510.1. XM_002418465.1.

Genome annotation databases

EnsemblFungiiCAX43811; CAX43811; CD36_20310.
GeneIDi8046058.
KEGGicdu:CD36_20310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992689 Genomic DNA. Translation: CAX43811.1.
RefSeqiXP_002418510.1. XM_002418465.1.

3D structure databases

ProteinModelPortaliB9WBP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573826.XP_002418510.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAX43811; CAX43811; CD36_20310.
GeneIDi8046058.
KEGGicdu:CD36_20310.

Organism-specific databases

CGDiCAL0000162212. Cd36_20310.

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
HOGENOMiHOG000019858.
KOiK00031.
OrthoDBiEOG092C2D51.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB9WBP0_CANDC
AccessioniPrimary (citable) accession number: B9WBP0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.