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B9WBP0

- B9WBP0_CANDC

UniProt

B9WBP0 - B9WBP0_CANDC

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Protein
Isocitrate dehydrogenase [NADP]
Gene
CD36_20310
Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Substrate By similarityUniRule annotation
Binding sitei111 – 1111NADP By similarityUniRule annotation
Binding sitei138 – 1381Substrate By similarityUniRule annotation
Binding sitei161 – 1611Substrate By similarityUniRule annotation
Sitei168 – 1681Critical for catalysis By similarityUniRule annotation
Sitei240 – 2401Critical for catalysis By similarityUniRule annotation
Metal bindingi280 – 2801Magnesium or manganese By similarityUniRule annotation
Binding sitei288 – 2881NADP By similarityUniRule annotation
Metal bindingi303 – 3031Magnesium or manganese By similarityUniRule annotation
Binding sitei356 – 3561NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1063NADP By similarityUniRule annotation
Nucleotide bindingi338 – 3436NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:CD36_20310Imported
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)Imported
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000002605: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi573826.CD36_20310.

Structurei

3D structure databases

ProteinModelPortaliB9WBP0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1297Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9WBP0-1 [UniParc]FASTAAdd to Basket

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MIRTTTTRTI NRTAMLSKHI RGFSSTASIL DKIKVKNPIV ELDGDEMTRI    50
IWQKIKDQLI LPYLDVNLKY YDLGIESRDA TNDQITIDAA NAIKEHGVGV 100
KCATITPDEA RVKEFNLKKM WLSPNGTIRN ILGGTVFRES IIIPCIPRLI 150
PGWKEPIVIG RHAFGDQYKA TDLVITEPGK LELRFTPASG GETQTHKVYD 200
YTGPGVGLAM YNTDESISGF ARASFNMALS KNLPLYMSTK NTILKKYDGR 250
FKDIFQDIYE NEYASEFEKK GLWYEHRLID DMVAQMIKSK GGFVMALKNY 300
DGDVQSDIVA QGFGSLGLMT SALMTPDGKA YEAEAAHGTV TRHYRQHQQG 350
KETSTNSIAS IFAWTRGLAQ RGRLDETPEV VDFANTLEKA TIDTVEVDRI 400
MTKDLALAMG KTDRSAYVTT TEFLDAVADR LKK 433
Length:433
Mass (Da):48,466
Last modified:March 24, 2009 - v1
Checksum:i8F5244366E04E46C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM992689 Genomic DNA. Translation: CAX43811.1.
RefSeqiXP_002418510.1. XM_002418465.1.

Genome annotation databases

GeneIDi8046058.
KEGGicdu:CD36_20310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM992689 Genomic DNA. Translation: CAX43811.1 .
RefSeqi XP_002418510.1. XM_002418465.1.

3D structure databases

ProteinModelPortali B9WBP0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 573826.CD36_20310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8046058.
KEGGi cdu:CD36_20310.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841.

Entry informationi

Entry nameiB9WBP0_CANDC
AccessioniPrimary (citable) accession number: B9WBP0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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