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B9VVT8

- B9VVT8_HUMAN

UniProt

B9VVT8 - B9VVT8_HUMAN

Protein
Submitted name:

HNF4alpha10/11/12

Gene

HNF4alpha

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HNF4alpha10/11/12Imported
    Submitted name:
    Hepatocyte nuclear factor 4-alphaImported
    Gene namesi
    Name:HNF4alphaImported
    Synonyms:HNF4AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:5024. HNF4A.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG082808.
    KOiK07292.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B9VVT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDWGQGFPQ DPPDTSPSEG TNLNAPNSLG VSALCAICGD RATGKHYGAS    50
    SCDGCKGFFR RSVRKNHMYS CRFSRQCVVD KDKRNQCRYC RLKKCFRAGM 100
    KKE 103
    Length:103
    Mass (Da):11,507
    Last modified:March 24, 2009 - v1
    Checksum:iDEC3966F09802721
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei103 – 1031Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL117382 Genomic DNA. No translation available.
    AL132772 Genomic DNA. No translation available.
    FJ608822 mRNA. Translation: ACM50922.1.
    RefSeqiNP_001274111.1. NM_001287182.1.
    NP_001274112.1. NM_001287183.1.
    NP_001274113.1. NM_001287184.1.
    UniGeneiHs.116462.

    Genome annotation databases

    EnsembliENST00000609262; ENSP00000476310; ENSG00000101076.
    GeneIDi3172.
    KEGGihsa:3172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL117382 Genomic DNA. No translation available.
    AL132772 Genomic DNA. No translation available.
    FJ608822 mRNA. Translation: ACM50922.1 .
    RefSeqi NP_001274111.1. NM_001287182.1.
    NP_001274112.1. NM_001287183.1.
    NP_001274113.1. NM_001287184.1.
    UniGenei Hs.116462.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000609262 ; ENSP00000476310 ; ENSG00000101076 .
    GeneIDi 3172.
    KEGGi hsa:3172.

    Organism-specific databases

    CTDi 3172.
    HGNCi HGNC:5024. HNF4A.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG082808.
    KOi K07292.

    Miscellaneous databases

    GenomeRNAii 3172.
    NextBioi 35482207.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion."
      Huang J., Levitsky L.L., Rhoads D.B.
      Exp. Cell Res. 315:1200-1211(2009)
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Ensembl
      Submitted (DEC-2013) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB9VVT8_HUMAN
    AccessioniPrimary (citable) accession number: B9VVT8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3